Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0571 | 0.5 | 0.5 |
Brugia malayi | Kringle domain containing protein | 0.0571 | 0.5 | 0.5 |
Plasmodium vivax | cysteine repeat modular protein 1, putative | 0.0571 | 0.5 | 0.5 |
Toxoplasma gondii | kringle domain-containing protein | 0.0571 | 0.5 | 0.5 |
Plasmodium falciparum | cysteine repeat modular protein 1 | 0.0571 | 0.5 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0571 | 0.5 | 0.5 |
Leishmania major | hypothetical protein, conserved | 0.0571 | 0.5 | 0.5 |
Loa Loa (eye worm) | TK/ROR protein kinase | 0.0571 | 0.5 | 0.5 |
Echinococcus granulosus | tissue type plasminogen activator | 0.0571 | 0.5 | 0.5 |
Onchocerca volvulus | 0.0571 | 0.5 | 0.5 | |
Echinococcus multilocularis | tissue type plasminogen activator | 0.0571 | 0.5 | 0.5 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0571 | 0.5 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Inhibition (binding) | = 1.8 % | Inhibition of T-type calcium channel Cav3.1 with alpha1G subunit expressed in HEK293 cells at 10 uM by FDSS6000 assay | ChEMBL. | 17035033 |
Inhibition (binding) | = 1.8 % | Inhibition of T-type calcium channel Cav3.1 with alpha1G subunit expressed in HEK293 cells at 10 uM by FDSS6000 assay | ChEMBL. | 17035033 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.