Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.093 | 0.5 | 0.5 |
Loa Loa (eye worm) | inward rectifying k channel family protein 1 | 0.093 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.093 | 0.5 | 0.5 |
Toxoplasma gondii | hypothetical protein | 0.093 | 0.5 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 58.8 uM | Inhibition of PTP1B in presence of 0.01% Triton X-100 | ChEMBL. | 17095232 |
IC50 (binding) | = 58.8 uM | Inhibition of PTP1B in presence of 0.01% Triton X-100 | ChEMBL. | 17095232 |
IC50 (binding) | = 87 uM | Inhibition of PTP1B | ChEMBL. | 17095232 |
IC50 (binding) | = 87 uM | Inhibition of PTP1B | ChEMBL. | 17095232 |
Inhibition (binding) | = 67.4 % | Inhibition of PTP1B at 100 uM | ChEMBL. | 17095232 |
Inhibition (binding) | = 67.4 % | Inhibition of PTP1B at 100 uM | ChEMBL. | 17095232 |
Ki (binding) | = 27.5 uM | Inhibition of PTP1B in presence of 0.01% Triton X-100 | ChEMBL. | 17095232 |
Ki (binding) | = 27.5 uM | Inhibition of PTP1B in presence of 0.01% Triton X-100 | ChEMBL. | 17095232 |
Ki (binding) | = 35 uM | Inhibition of PTP1B | ChEMBL. | 17095232 |
Ki (binding) | = 35 uM | Inhibition of PTP1B | ChEMBL. | 17095232 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.