Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (functional) | 0 | Inhibition of Fe(II)/ascorbate-induced lipid peroxidation in Fischer 344 rat hepatic microsomal membranes | ChEMBL. | 17126019 |
Inhibition (functional) | = 0 % | Inhibition of COX2 production in splenocytes of adjuvant arthrtis Fischer 344 rat at 0.15 mmol/kg, ip after 14 days | ChEMBL. | 17126019 |
Inhibition (functional) | = 0.3 % | Inhibition of COX2 production in splenocytes of adjuvant arthrtis Fischer 344 rat at 0.15 mmol/kg, ip after 6 days | ChEMBL. | 17126019 |
Inhibition (binding) | = 64 % | Inhibition of Fischer 344 rat brain acetylcholine esterase at 0.6 mM | ChEMBL. | 17126019 |
Inhibition (binding) | = 64 % | Inhibition of Fischer 344 rat brain acetylcholine esterase at 0.6 mM | ChEMBL. | 17126019 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.