Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | cathepsin b | 0.0272 | 0.2855 | 0.3669 |
Trypanosoma cruzi | calpain-like cysteine peptidase, putative | 0.0061 | 0.0228 | 0.0308 |
Trypanosoma cruzi | calpain cysteine peptidase, putative | 0.0061 | 0.0228 | 0.0308 |
Echinococcus multilocularis | cathepsin b | 0.0272 | 0.2855 | 0.3669 |
Trichomonas vaginalis | DEAD box ATP-dependent RNA helicase, putative | 0.0635 | 0.739 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0048 | 0.007 | 0.0095 |
Echinococcus granulosus | eukaryotic initiation factor 4A III | 0.0635 | 0.739 | 1 |
Trypanosoma brucei | calpain-like protein, putative | 0.0061 | 0.0228 | 0.0308 |
Echinococcus granulosus | cathepsin b | 0.0272 | 0.2855 | 0.3669 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.0272 | 0.2855 | 0.2689 |
Brugia malayi | calpain family protein 1 | 0.0161 | 0.1479 | 0.2002 |
Trypanosoma brucei | calpain-like protein, putative | 0.0061 | 0.0228 | 0.0308 |
Leishmania major | cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like | 0.009 | 0.0587 | 0.0794 |
Trypanosoma brucei | antigen, putative | 0.0061 | 0.0228 | 0.0308 |
Trypanosoma cruzi | calpain-like cysteine peptidase, putative | 0.0061 | 0.0228 | 0.0308 |
Brugia malayi | calpain 7 | 0.0061 | 0.0228 | 0.0308 |
Toxoplasma gondii | eukaryotic initiation factor-4A, putative | 0.0635 | 0.739 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0635 | 0.739 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0143 | 0.1251 | 0.1693 |
Echinococcus multilocularis | eukaryotic initiation factor 4A III | 0.0635 | 0.739 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0161 | 0.1479 | 0.2002 |
Leishmania major | calpain, putative,cysteine peptidase, Clan CA, family C2, putative | 0.0061 | 0.0228 | 0.0308 |
Echinococcus multilocularis | family C2 unassigned peptidase (C02 family) | 0.0175 | 0.1651 | 0.1987 |
Plasmodium falciparum | eukaryotic initiation factor 4A | 0.0635 | 0.739 | 0.5 |
Trypanosoma cruzi | cysteine peptidase, Clan CA, family C2, putative | 0.0061 | 0.0228 | 0.0308 |
Trypanosoma brucei | cysteine peptidase C (CPC) | 0.009 | 0.0587 | 0.0794 |
Schistosoma mansoni | family C2 unassigned peptidase (C02 family) | 0.0175 | 0.1651 | 0.1456 |
Trypanosoma cruzi | cysteine peptidase, Clan CA, family C2, putative | 0.0061 | 0.0228 | 0.0308 |
Schistosoma mansoni | family C2 unassigned peptidase (C02 family) | 0.0161 | 0.1479 | 0.1281 |
Trichomonas vaginalis | DEAD box ATP-dependent RNA helicase, putative | 0.0635 | 0.739 | 1 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.0272 | 0.2855 | 0.2689 |
Leishmania major | eukaryotic initiation factor 4a, putative | 0.0635 | 0.739 | 1 |
Echinococcus granulosus | eukaryotic initiation factor 4A | 0.0635 | 0.739 | 1 |
Trichomonas vaginalis | DEAD box ATP-dependent RNA helicase, putative | 0.0635 | 0.739 | 1 |
Trypanosoma cruzi | cysteine peptidase, Clan CA, family C2, putative | 0.0061 | 0.0228 | 0.0308 |
Trypanosoma cruzi | calpain-like cysteine peptidase, putative | 0.0061 | 0.0228 | 0.0308 |
Trypanosoma brucei | calpain-like cysteine peptidase, putative | 0.0061 | 0.0228 | 0.0308 |
Schistosoma mansoni | family C2 unassigned peptidase (C02 family) | 0.0175 | 0.1651 | 0.1456 |
Loa Loa (eye worm) | calpain | 0.0061 | 0.0228 | 0.0308 |
Trypanosoma brucei | Eukaryotic initiation factor 4A-1 | 0.0635 | 0.739 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.01 | 0.0721 | 0.0976 |
Trypanosoma cruzi | Eukaryotic initiation factor 4A-1 | 0.0635 | 0.739 | 1 |
Brugia malayi | cathepsin B-like cysteine proteinase | 0.0272 | 0.2855 | 0.3864 |
Loa Loa (eye worm) | cathepsin B | 0.009 | 0.0587 | 0.0794 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0048 | 0.007 | 0.0095 |
Loa Loa (eye worm) | hypothetical protein | 0.0272 | 0.2855 | 0.3864 |
Loa Loa (eye worm) | hypothetical protein | 0.0119 | 0.0949 | 0.1284 |
Trypanosoma cruzi | cysteine peptidase, Clan CA, family C2, putative | 0.0061 | 0.0228 | 0.0308 |
Trypanosoma cruzi | cysteine peptidase C (CPC), putative | 0.009 | 0.0587 | 0.0794 |
Brugia malayi | eukaryotic initiation factor 4A | 0.0635 | 0.739 | 1 |
Trypanosoma cruzi | calpain-like cysteine peptidase, putative | 0.0061 | 0.0228 | 0.0308 |
Echinococcus multilocularis | calpain A | 0.0175 | 0.1657 | 0.1995 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0048 | 0.007 | 0.0095 |
Echinococcus multilocularis | calpain family protein 1, d | 0.0119 | 0.0949 | 0.1007 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.0272 | 0.2855 | 0.2689 |
Plasmodium vivax | RNA helicase-1, putative | 0.0635 | 0.739 | 1 |
Echinococcus multilocularis | eukaryotic initiation factor 4A | 0.0635 | 0.739 | 1 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0048 | 0.007 | 0.0095 |
Brugia malayi | calpain family protein 1 | 0.0161 | 0.1479 | 0.2002 |
Echinococcus granulosus | family C2 unassigned peptidase C02 family | 0.0175 | 0.1651 | 0.1987 |
Treponema pallidum | ATP-dependent RNA helicase | 0.0635 | 0.739 | 0.5 |
Echinococcus granulosus | calpain A | 0.0175 | 0.1657 | 0.1995 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C2, putative | 0.0061 | 0.0228 | 0.0308 |
Trypanosoma cruzi | calpain-like cysteine peptidase, putative | 0.0061 | 0.0228 | 0.0308 |
Trypanosoma brucei | calpain-like protein, putative | 0.0061 | 0.0228 | 0.0308 |
Echinococcus multilocularis | cathepsin b | 0.0272 | 0.2855 | 0.3669 |
Trypanosoma cruzi | cysteine peptidase C (CPC), putative | 0.0272 | 0.2855 | 0.3864 |
Onchocerca volvulus | Eukaryotic initiation factor 4A homolog | 0.0635 | 0.739 | 1 |
Entamoeba histolytica | DEAD/DEAH box helicase, putative | 0.0635 | 0.739 | 1 |
Leishmania major | calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative | 0.0061 | 0.0228 | 0.0308 |
Loa Loa (eye worm) | calpain family protein 1 | 0.0161 | 0.1479 | 0.2002 |
Giardia lamblia | Translation initiation factor eIF-4A, putative | 0.0635 | 0.739 | 1 |
Schistosoma mansoni | DEAD box ATP-dependent RNA helicase | 0.0635 | 0.739 | 0.7329 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.009 | 0.0587 | 0.0368 |
Trypanosoma brucei | calpain-like protein, putative | 0.0061 | 0.0228 | 0.0308 |
Trypanosoma cruzi | Eukaryotic initiation factor 4A-1 | 0.0635 | 0.739 | 1 |
Leishmania major | calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative | 0.0061 | 0.0228 | 0.0308 |
Schistosoma mansoni | DEAD box ATP-dependent RNA helicase | 0.0635 | 0.739 | 0.7329 |
Leishmania major | eukaryotic initiation factor 4a, putative | 0.0635 | 0.739 | 1 |
Loa Loa (eye worm) | calpain family protein 1 | 0.0119 | 0.0949 | 0.1284 |
Mycobacterium tuberculosis | Probable cold-shock DeaD-box protein A homolog DeaD (ATP-dependent RNA helicase dead homolog) | 0.0635 | 0.739 | 0.5 |
Schistosoma mansoni | SmCB2 peptidase (C01 family) | 0.0272 | 0.2855 | 0.2689 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Inhibition (binding) | = 0 % | Inhibition of ovine COX1 at 100 uM | ChEMBL. | 17079150 |
Inhibition (binding) | = 0 % | Inhibition of ovine COX1 at 100 uM | ChEMBL. | 17079150 |
Inhibition (binding) | = 5 % | Inhibition of ovine COX2 at 100 uM | ChEMBL. | 17079150 |
Inhibition (binding) | = 5 % | Inhibition of ovine COX2 at 100 uM | ChEMBL. | 17079150 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.