Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Onchocerca volvulus | Eukaryotic initiation factor 4A homolog | 0.0634 | 0.377 | 0.5 |
Echinococcus granulosus | GPCR family 2 | 0.0333692 | 0 | 0.5 |
Toxoplasma gondii | eukaryotic initiation factor-4A, putative | 0.0634 | 0.377 | 0.5 |
Trypanosoma brucei | Eukaryotic initiation factor 4A-1 | 0.0634 | 0.377 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0755 | 0.5371 | 1 |
Echinococcus multilocularis | diuretic hormone 44 receptor GPRdih2 | 0.0333692 | 0 | 0.5 |
Echinococcus multilocularis | eukaryotic initiation factor 4A | 0.0634 | 0.377 | 1 |
Trichomonas vaginalis | DEAD box ATP-dependent RNA helicase, putative | 0.0634 | 0.377 | 0.5 |
Schistosoma mansoni | DEAD box ATP-dependent RNA helicase | 0.0634 | 0.377 | 0.7019 |
Leishmania major | eukaryotic initiation factor 4a, putative | 0.0634 | 0.377 | 0.5 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.105463 | 1 | 1 |
Entamoeba histolytica | DEAD/DEAH box helicase, putative | 0.0634 | 0.377 | 0.5 |
Trypanosoma cruzi | Eukaryotic initiation factor 4A-1 | 0.0634 | 0.377 | 0.5 |
Schistosoma mansoni | DEAD box ATP-dependent RNA helicase | 0.0634 | 0.377 | 0.7019 |
Loa Loa (eye worm) | hypothetical protein | 0.0720939 | 0.537143 | 0.537143 |
Echinococcus granulosus | eukaryotic initiation factor 4A | 0.0634 | 0.377 | 1 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0755 | 0.5371 | 0.5371 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.1105 | 1 | 1 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.105463 | 1 | 1 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.105463 | 1 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0720939 | 0.537143 | 1 |
Trichomonas vaginalis | DEAD box ATP-dependent RNA helicase, putative | 0.0634 | 0.377 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0755 | 0.5371 | 0.5371 |
Trichomonas vaginalis | DEAD box ATP-dependent RNA helicase, putative | 0.0634 | 0.377 | 0.5 |
Echinococcus granulosus | diuretic hormone 44 receptor GPRdih2 | 0.0333692 | 0 | 0.5 |
Brugia malayi | eukaryotic initiation factor 4A | 0.0634 | 0.377 | 0.377 |
Giardia lamblia | Translation initiation factor eIF-4A, putative | 0.0634 | 0.377 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.105463 | 1 | 1 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0720939 | 0.537143 | 0.537143 |
Echinococcus granulosus | eukaryotic initiation factor 4A III | 0.0634 | 0.377 | 1 |
Leishmania major | eukaryotic initiation factor 4a, putative | 0.0634 | 0.377 | 0.5 |
Echinococcus multilocularis | eukaryotic initiation factor 4A III | 0.0634 | 0.377 | 1 |
Plasmodium vivax | RNA helicase-1, putative | 0.0634 | 0.377 | 0.5 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.1105 | 1 | 1 |
Echinococcus multilocularis | GPCR, family 2 | 0.0333692 | 0 | 0.5 |
Echinococcus multilocularis | cadherin EGF LAG seven pass G type receptor | 0.0333692 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.1105 | 1 | 1 |
Mycobacterium tuberculosis | Probable cold-shock DeaD-box protein A homolog DeaD (ATP-dependent RNA helicase dead homolog) | 0.0634 | 0.377 | 0.5 |
Plasmodium falciparum | eukaryotic initiation factor 4A | 0.0634 | 0.377 | 0.5 |
Trypanosoma cruzi | Eukaryotic initiation factor 4A-1 | 0.0634 | 0.377 | 0.5 |
Echinococcus granulosus | cadherin EGF LAG seven pass G type receptor | 0.0333692 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0634 | 0.377 | 0.377 |
Treponema pallidum | ATP-dependent RNA helicase | 0.0634 | 0.377 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | = -5.2 | Antimycobacterial activity against drug-sensitive Mycobacterium tuberculosis H37Rv by microplate alamar blue assay | ChEMBL. | 17107805 |
Inhibition (functional) | = 66 % | Antimycobacterial activity against drug-sensitive Mycobacterium tuberculosis H37Rv at 6.250 ug/mL relative to isoniazid by microplate alamar blue assay | ChEMBL. | 17107805 |
Inhibition (functional) | = 66 % | Antimycobacterial activity against drug-sensitive Mycobacterium tuberculosis H37Rv at 6.250 ug/mL relative to isoniazid by microplate alamar blue assay | ChEMBL. | 17107805 |
Log IC50 (functional) | = 5.2 | Antimycobacterial activity against drug-sensitive Mycobacterium tuberculosis H37Rv by microplate alamar blue assay | ChEMBL. | 17107805 |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Mycobacterium tuberculosis | ChEMBL23 | 17107805 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.