Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | arachidonate 5 lipoxygenase | 0.0107 | 0.0526 | 0.0733 |
Plasmodium falciparum | inosine-5'-monophosphate dehydrogenase | 0.0395 | 0.4809 | 0.5 |
Schistosoma mansoni | lipoxygenase | 0.0107 | 0.0526 | 0.0526 |
Schistosoma mansoni | bcl-2 homologous antagonist/killer (bak) | 0.0165 | 0.1396 | 0.1396 |
Brugia malayi | inosine-5'-monophosphate dehydrogenase | 0.0174 | 0.1533 | 0.2492 |
Brugia malayi | bHLH-PAS transcription factor | 0.019 | 0.1763 | 0.2865 |
Loa Loa (eye worm) | hypothetical protein | 0.0485 | 0.6154 | 0.8613 |
Schistosoma mansoni | hypothetical protein | 0.0165 | 0.1396 | 0.1396 |
Mycobacterium ulcerans | inosine 5-monophosphate dehydrogenase | 0.0395 | 0.4809 | 0.8916 |
Echinococcus multilocularis | transfer RNA-Lys | 0.019 | 0.1763 | 0.2456 |
Mycobacterium ulcerans | inosine 5-monophosphate dehydrogenase | 0.0199 | 0.1904 | 0.0412 |
Echinococcus granulosus | single minded 2 | 0.019 | 0.1763 | 0.2456 |
Echinococcus multilocularis | inosine 5' monophosphate dehydrogenase 2 | 0.042 | 0.5179 | 0.7216 |
Echinococcus multilocularis | arachidonate 5 lipoxygenase | 0.0107 | 0.0526 | 0.0733 |
Schistosoma mansoni | single-minded | 0.0257 | 0.2754 | 0.2754 |
Mycobacterium leprae | Probable inosine-5'-monophosphate dehydrogenase GuaB2 (IMP dehydrogenase) (IMPDH) (IMPD) | 0.042 | 0.5179 | 1 |
Trypanosoma brucei | GMP reductase | 0.042 | 0.5179 | 0.5 |
Trypanosoma cruzi | inosine-5'-monophosphate dehydrogenase, putative | 0.042 | 0.5179 | 0.5 |
Loa Loa (eye worm) | apoptosis regulator protein | 0.0165 | 0.1396 | 0.1954 |
Trypanosoma cruzi | inosine-5'-monophosphate dehydrogenase, putative | 0.042 | 0.5179 | 0.5 |
Echinococcus granulosus | EGFP:Bcl2 fusion protein | 0.0165 | 0.1396 | 0.1945 |
Schistosoma mansoni | inosine-5-monophosphate dehydrogenase | 0.042 | 0.5179 | 0.5179 |
Echinococcus multilocularis | Bcl 2 ous antagonist:killer | 0.0165 | 0.1396 | 0.1945 |
Trypanosoma brucei | inosine-5'-monophosphate dehydrogenase | 0.042 | 0.5179 | 0.5 |
Loa Loa (eye worm) | GMP reductase | 0.0174 | 0.1533 | 0.2146 |
Leishmania major | guanosine monophosphate reductase | 0.042 | 0.5179 | 0.5 |
Echinococcus granulosus | Bcl 2 ous antagonist:killer | 0.0165 | 0.1396 | 0.1945 |
Echinococcus multilocularis | EGFP:Bcl2 fusion protein | 0.0165 | 0.1396 | 0.1945 |
Trypanosoma cruzi | inosine-5'-monophosphate dehydrogenase, putative | 0.042 | 0.5179 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0165 | 0.1396 | 0.1396 |
Brugia malayi | GMP reductase | 0.0174 | 0.1533 | 0.2492 |
Trypanosoma cruzi | GMP reductase | 0.042 | 0.5179 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0165 | 0.1396 | 0.1396 |
Brugia malayi | inosine-5'-monophosphate dehydrogenase | 0.0174 | 0.1533 | 0.2492 |
Schistosoma mansoni | apoptosis regulator bax | 0.0165 | 0.1396 | 0.1396 |
Onchocerca volvulus | Putative GMP reductase | 0.0174 | 0.1533 | 0.2146 |
Mycobacterium ulcerans | inosine 5'-monophosphate dehydrogenase | 0.042 | 0.5179 | 1 |
Wolbachia endosymbiont of Brugia malayi | IMP dehydrogenase | 0.042 | 0.5179 | 0.5 |
Echinococcus granulosus | inosine 5' monophosphate dehydrogenase 2 | 0.042 | 0.5179 | 0.7216 |
Onchocerca volvulus | 0.0552 | 0.7145 | 1 | |
Loa Loa (eye worm) | hypothetical protein | 0.0552 | 0.7145 | 1 |
Toxoplasma gondii | IMP dehydrogenas | 0.042 | 0.5179 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0487 | 0.6186 | 0.8659 |
Brugia malayi | Apoptosis regulator proteins, Bcl-2 family protein | 0.0165 | 0.1396 | 0.2269 |
Mycobacterium leprae | Probable inosine-5'-monophosphate dehydrogenase GuaB3 (IMP dehydrogenase 2) (inosinic acid dehydrogenase) (inosinate dehydrogena | 0.022 | 0.2216 | 0.0954 |
Echinococcus granulosus | aryl hydrocarbon receptor | 0.0554 | 0.7178 | 1 |
Loa Loa (eye worm) | IMP dehydrogenase 1 | 0.042 | 0.5179 | 0.7249 |
Brugia malayi | aryl hydrocarbon receptor AHR-1 | 0.0485 | 0.6154 | 1 |
Mycobacterium tuberculosis | Probable inosine-5'-monophosphate dehydrogenase GuaB2 (imp dehydrogenase) (inosinic acid dehydrogenase) (inosinate dehydrogenase | 0.042 | 0.5179 | 1 |
Leishmania major | inosine-5-monophosphate dehydrogenase | 0.042 | 0.5179 | 0.5 |
Echinococcus multilocularis | aryl hydrocarbon receptor | 0.0554 | 0.7178 | 1 |
Brugia malayi | PAS domain containing protein | 0.0257 | 0.2754 | 0.4476 |
Brugia malayi | inosine-5'-monophosphate dehydrogenase family protein | 0.042 | 0.5179 | 0.8417 |
Loa Loa (eye worm) | hypothetical protein | 0.0165 | 0.1396 | 0.1954 |
Trypanosoma cruzi | GMP reductase | 0.042 | 0.5179 | 0.5 |
Onchocerca volvulus | 0.0192 | 0.1796 | 0.2514 | |
Plasmodium vivax | inosine-5'-monophosphate dehydrogenase, putative | 0.0395 | 0.4809 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Diet (functional) | < 66 % | In vivo triglyceride lowering activity dosed at 0.10 % of the diet. | ChEMBL. | 6604817 |
Diet (functional) | < 73 % | In vivo sterol lowering activity at dose of 0.10 % of the diet | ChEMBL. | 6604817 |
Diet (functional) | = 87 % | In vivo sterol lowering activity when dosed as 0.03 % of the diet | ChEMBL. | 6604817 |
Diet (functional) | = 87 % | In vivo triglyceride lowering activity when dosed as 0.01 % of the diet | ChEMBL. | 6604817 |
Diet (functional) | = 88 % | In vivo triglyceride lowering activity when dosed at 0.03 % of the diet | ChEMBL. | 6604817 |
Diet (functional) | = 100 % | In vivo sterol lowering activity when dosed as 0.01 % of the diet | ChEMBL. | 6604817 |
Inhibition (binding) | = 21 % | In vitro inhibition of acyl coenzyme A:cholesterol acyltransferase | ChEMBL. | 6604817 |
Inhibition (binding) | = 21 % | In vitro inhibition of acyl coenzyme A:cholesterol acyltransferase | ChEMBL. | 6604817 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.