Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | plasminogen activator, urokinase | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Echinococcus granulosus | Mastin | plasminogen activator, urokinase | 414 aa | 340 aa | 24.4 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Leishmania major | eukaryotic initiation factor 4a, putative | 0.0055 | 0.5 | 0.5 |
Trichomonas vaginalis | DEAD box ATP-dependent RNA helicase, putative | 0.0055 | 0.5 | 0.5 |
Trichomonas vaginalis | DEAD box ATP-dependent RNA helicase, putative | 0.0055 | 0.5 | 0.5 |
Mycobacterium tuberculosis | Probable cold-shock DeaD-box protein A homolog DeaD (ATP-dependent RNA helicase dead homolog) | 0.0055 | 0.5 | 0.5 |
Onchocerca volvulus | Eukaryotic initiation factor 4A homolog | 0.0055 | 0.5 | 0.5 |
Echinococcus granulosus | eukaryotic initiation factor 4A III | 0.0055 | 0.5 | 0.5 |
Trypanosoma cruzi | Eukaryotic initiation factor 4A-1 | 0.0055 | 0.5 | 0.5 |
Plasmodium falciparum | eukaryotic initiation factor 4A | 0.0055 | 0.5 | 0.5 |
Echinococcus granulosus | eukaryotic initiation factor 4A | 0.0055 | 0.5 | 0.5 |
Entamoeba histolytica | DEAD/DEAH box helicase, putative | 0.0055 | 0.5 | 0.5 |
Plasmodium vivax | RNA helicase-1, putative | 0.0055 | 0.5 | 0.5 |
Schistosoma mansoni | DEAD box ATP-dependent RNA helicase | 0.0055 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0055 | 0.5 | 0.5 |
Toxoplasma gondii | eukaryotic initiation factor-4A, putative | 0.0055 | 0.5 | 0.5 |
Treponema pallidum | ATP-dependent RNA helicase | 0.0055 | 0.5 | 0.5 |
Giardia lamblia | Translation initiation factor eIF-4A, putative | 0.0055 | 0.5 | 0.5 |
Trichomonas vaginalis | DEAD box ATP-dependent RNA helicase, putative | 0.0055 | 0.5 | 0.5 |
Echinococcus multilocularis | eukaryotic initiation factor 4A | 0.0055 | 0.5 | 0.5 |
Schistosoma mansoni | DEAD box ATP-dependent RNA helicase | 0.0055 | 0.5 | 0.5 |
Echinococcus multilocularis | eukaryotic initiation factor 4A III | 0.0055 | 0.5 | 0.5 |
Trypanosoma brucei | Eukaryotic initiation factor 4A-1 | 0.0055 | 0.5 | 0.5 |
Leishmania major | eukaryotic initiation factor 4a, putative | 0.0055 | 0.5 | 0.5 |
Trypanosoma cruzi | Eukaryotic initiation factor 4A-1 | 0.0055 | 0.5 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Ki (binding) | = 1.6 nM | Inhibition of human uPA | ChEMBL. | 17447747 |
Ki (binding) | = 1.6 nM | Inhibition of human uPA | ChEMBL. | 17447747 |
Ki (binding) | = 34400 nM | Inhibition of human tPA | ChEMBL. | 17447747 |
Ki (binding) | = 34400 nM | Inhibition of human tPA | ChEMBL. | 17447747 |
Ki (binding) | > 30 uM | Inhibition of human plasmin | ChEMBL. | 17447747 |
Ki (binding) | > 30 uM | Inhibition of human plasmin | ChEMBL. | 17447747 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.