Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma cruzi | Eukaryotic initiation factor 4A-1 | 0.0569 | 1 | 0.5 |
Leishmania major | eukaryotic initiation factor 4a, putative | 0.0569 | 1 | 0.5 |
Trypanosoma brucei | Eukaryotic initiation factor 4A-1 | 0.0569 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0569 | 1 | 1 |
Echinococcus multilocularis | eukaryotic initiation factor 4A III | 0.0569 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0074 | 0.0214 | 0.0214 |
Schistosoma mansoni | DEAD box ATP-dependent RNA helicase | 0.0569 | 1 | 1 |
Toxoplasma gondii | eukaryotic initiation factor-4A, putative | 0.0569 | 1 | 0.5 |
Echinococcus granulosus | eukaryotic initiation factor 4A III | 0.0569 | 1 | 1 |
Trichomonas vaginalis | DEAD box ATP-dependent RNA helicase, putative | 0.0569 | 1 | 0.5 |
Entamoeba histolytica | DEAD/DEAH box helicase, putative | 0.0569 | 1 | 1 |
Trichomonas vaginalis | DEAD box ATP-dependent RNA helicase, putative | 0.0569 | 1 | 0.5 |
Brugia malayi | hypothetical protein | 0.0228 | 0.3265 | 0.3265 |
Treponema pallidum | ATP-dependent RNA helicase | 0.0569 | 1 | 0.5 |
Echinococcus multilocularis | survival motor neuron protein 1 | 0.0228 | 0.3265 | 0.3265 |
Schistosoma mansoni | DEAD box ATP-dependent RNA helicase | 0.0569 | 1 | 1 |
Plasmodium vivax | RNA helicase-1, putative | 0.0569 | 1 | 0.5 |
Plasmodium falciparum | eukaryotic initiation factor 4A | 0.0569 | 1 | 0.5 |
Echinococcus granulosus | eukaryotic initiation factor 4A | 0.0569 | 1 | 1 |
Echinococcus granulosus | survival motor neuron protein 1 | 0.0228 | 0.3265 | 0.3265 |
Onchocerca volvulus | Eukaryotic initiation factor 4A homolog | 0.0569 | 1 | 0.5 |
Mycobacterium tuberculosis | Probable cold-shock DeaD-box protein A homolog DeaD (ATP-dependent RNA helicase dead homolog) | 0.0569 | 1 | 1 |
Echinococcus multilocularis | eukaryotic initiation factor 4A | 0.0569 | 1 | 1 |
Trypanosoma cruzi | Eukaryotic initiation factor 4A-1 | 0.0569 | 1 | 0.5 |
Giardia lamblia | Translation initiation factor eIF-4A, putative | 0.0569 | 1 | 0.5 |
Leishmania major | eukaryotic initiation factor 4a, putative | 0.0569 | 1 | 0.5 |
Trichomonas vaginalis | DEAD box ATP-dependent RNA helicase, putative | 0.0569 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0228 | 0.3265 | 0.3265 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Ki (binding) | = 2.9 nM | Displacement of [125I]IMPY from human beta amyloid plaque in brain homogenates | ChEMBL. | 17447752 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.