Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | Glutamate receptor, ionotropic kainate 2 | 0.0338 | 0.1122 | 0.1405 |
Echinococcus multilocularis | nmda type glutamate receptor | 0.1016 | 0.7984 | 1 |
Brugia malayi | Glutamate receptor 2 precursor | 0.0281 | 0.0547 | 0.5 |
Echinococcus granulosus | Glutamate receptor ionotropic kainate 2 | 0.0338 | 0.1122 | 0.1405 |
Echinococcus granulosus | nmda type glutamate receptor | 0.1016 | 0.7984 | 1 |
Brugia malayi | Glutamate receptor 1 precursor | 0.0281 | 0.0547 | 0.5 |
Echinococcus multilocularis | glutamate (NMDA) receptor subunit | 0.041 | 0.1854 | 0.2322 |
Loa Loa (eye worm) | glutamate receptor 2 | 0.0281 | 0.0547 | 0.5 |
Echinococcus multilocularis | Glutamate receptor, ionotropic kainate 2 | 0.0338 | 0.1122 | 0.1405 |
Echinococcus granulosus | Glutamate receptor ionotropic kainate 2 | 0.0338 | 0.1122 | 0.1405 |
Echinococcus multilocularis | glutamate receptor, ionotrophic, AMPA 3 | 0.0338 | 0.1122 | 0.1405 |
Loa Loa (eye worm) | glutamate receptor 1 | 0.0281 | 0.0547 | 0.5 |
Echinococcus granulosus | glutamate receptor 2 | 0.0338 | 0.1122 | 0.1405 |
Echinococcus granulosus | Glutamate receptor ionotropic kainate 2 | 0.0338 | 0.1122 | 0.1405 |
Echinococcus granulosus | glutamate receptor ionotrophic AMPA 3 | 0.0338 | 0.1122 | 0.1405 |
Echinococcus multilocularis | glutamate receptor 2 | 0.0281 | 0.0547 | 0.0685 |
Echinococcus multilocularis | glutamate receptor NMDA | 0.0877 | 0.658 | 0.8242 |
Echinococcus multilocularis | glutamate receptor 2 | 0.0338 | 0.1122 | 0.1405 |
Echinococcus multilocularis | nmda type glutamate receptor | 0.0934 | 0.7156 | 0.8962 |
Echinococcus multilocularis | Glutamate receptor, ionotropic kainate 2 | 0.0338 | 0.1122 | 0.1405 |
Echinococcus granulosus | glutamate NMDA receptor subunit | 0.041 | 0.1854 | 0.2322 |
Echinococcus granulosus | nmda type glutamate receptor | 0.0934 | 0.7156 | 0.8962 |
Echinococcus granulosus | glutamate receptor NMDA | 0.0877 | 0.658 | 0.8242 |
Schistosoma mansoni | glutamate receptor NMDA | 0.041 | 0.1854 | 0.1383 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (functional) | 0 | Cell cycle arrest in human K562 cells assessed as decrease in S and G0/G1 phase accumulation at 25 nM after 24 hrs | ChEMBL. | 17419607 |
Activity (functional) | 0 | Cell cycle arrest in human K562 cells assessed as increase in G2/M phase accumulation at 25 nM after 24 hrs | ChEMBL. | 17419607 |
IC50 (functional) | = 7.7 nM | Antiproliferative effect against human CEM cells after 3 days | ChEMBL. | 17419607 |
IC50 (functional) | = 7.7 nM | Antiproliferative effect against human CEM cells after 3 days | ChEMBL. | 17419607 |
IC50 (ADMET) | = 7.7 nM | Antiproliferative activity against human CEM cells after 2 days | ChEMBL. | 18755591 |
IC50 (functional) | = 7.7 nM | Antiproliferative activity against human CEM cells after 2 days by coulter counting | ChEMBL. | 20579891 |
IC50 (functional) | = 10 nM | Antiproliferative effect against human Molt4/C8 cells after 3 days | ChEMBL. | 17419607 |
IC50 (functional) | = 39 nM | Antiproliferative effect against mouse L210 cells after 2 days | ChEMBL. | 17419607 |
IC50 (functional) | = 39 nM | Antiproliferative activity against mouse L1210 cells after 2 days | ChEMBL. | 18755591 |
IC50 (functional) | = 39 nM | Antiproliferative activity against mouse L1210 cells after 2 days by coulter counting | ChEMBL. | 20579891 |
IC50 (functional) | = 46 nM | Antiproliferative effect against mouse FM3A cells after 2 days | ChEMBL. | 17419607 |
IC50 (functional) | = 46 nM | Antiproliferative effect against mouse FM3A cells after 2 days | ChEMBL. | 17419607 |
IC50 (functional) | = 46 nM | Antiproliferative activity against mouse FM3A cells after 2 days | ChEMBL. | 18755591 |
IC50 (functional) | = 46 nM | Antiproliferative activity against mouse FM3A cells after 2 days by coulter counting | ChEMBL. | 20579891 |
IC50 (binding) | = 1.3 uM | Inhibition of bovine brain tubulin polymerization | ChEMBL. | 17419607 |
IC50 (binding) | = 60 uM | Displacement of [3H]colchicine from bovine brain tubulin at 1 uM | ChEMBL. | 17419607 |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Homo sapiens | ChEMBL23 | 17419607 | |
Mus musculus | ChEMBL23 | 17419607 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.