Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma cruzi | serine peptidase, Clan SC, Family S9B | 0.2297 | 0.3197 | 1 |
Loa Loa (eye worm) | prolyl oligopeptidase | 0.5547 | 1 | 1 |
Schistosoma mansoni | family S28 unassigned peptidase (S28 family) | 0.3491 | 0.5697 | 0.5309 |
Echinococcus granulosus | Lysosomal Pro X carboxypeptidase | 0.3491 | 0.5697 | 0.5309 |
Loa Loa (eye worm) | hypothetical protein | 0.1166 | 0.0828 | 0.0828 |
Loa Loa (eye worm) | hypothetical protein | 0.1527 | 0.1584 | 0.1584 |
Leishmania major | dipeptidyl-peptidase 8-like serine peptidase, putative,serine peptidase, Clan SC, Family S9B | 0.2297 | 0.3197 | 1 |
Brugia malayi | prolyl oligopeptidase family protein | 0.2297 | 0.3197 | 0.2582 |
Echinococcus granulosus | Dipeptidyl peptidase 9 | 0.2297 | 0.3197 | 0.2582 |
Toxoplasma gondii | dipeptidyl peptidase iv (dpp iv) n-terminal region domain-containing protein | 0.2071 | 0.2722 | 1 |
Echinococcus multilocularis | Dipeptidyl peptidase 9 | 0.2297 | 0.3197 | 0.2582 |
Trypanosoma cruzi | dipeptidyl-peptidase 8-like serine peptidase | 0.2297 | 0.3197 | 1 |
Trypanosoma brucei | serine peptidase, Clan SC, Family S9B | 0.2297 | 0.3197 | 1 |
Echinococcus multilocularis | dipeptidyl aminopeptidaseprotein | 0.5547 | 1 | 1 |
Echinococcus granulosus | dipeptidyl aminopeptidaseprotein | 0.5547 | 1 | 1 |
Echinococcus multilocularis | Lysosomal Pro X carboxypeptidase | 0.3491 | 0.5697 | 0.5309 |
Schistosoma mansoni | dipeptidyl-peptidase 9 (S09 family) | 0.2297 | 0.3197 | 0.2582 |
Trypanosoma brucei | Dipeptidyl-peptidase 8-like, putative | 0.2297 | 0.3197 | 1 |
Brugia malayi | hypothetical protein | 0.1527 | 0.1584 | 0.0824 |
Onchocerca volvulus | Dipeptidyl peptidase family member 1 homolog | 0.5547 | 1 | 1 |
Schistosoma mansoni | subfamily S9B unassigned peptidase (S09 family) | 0.5547 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 45 uM | Inhibition of Bacillus subtilis NAD synthetase by fluorescence based assay | ChEMBL. | 17489580 |
MIC (functional) | = 1.56 uM | Antibacterial activity against Bacillus subtilis ATCC 14289 | ChEMBL. | 17489580 |
MIC (functional) | = 1.56 uM | Antibacterial activity against methicillin-resistant Staphylococcus aureus ATCC 33591 | ChEMBL. | 17489580 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.