Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0787 | 0.3279 | 1 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0787 | 0.3279 | 1 |
Echinococcus multilocularis | neuropeptide receptor | 0.2006 | 1 | 1 |
Toxoplasma gondii | 1,3-beta-glucan synthase component protein | 0.1299 | 0.6103 | 0.5 |
Echinococcus multilocularis | G protein coupled receptor 139 | 0.2006 | 1 | 1 |
Schistosoma mansoni | neuropeptide receptor | 0.2006 | 1 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Inhibition (functional) | = 81 % | Growth inhibition of human SF268 cells at 10 uM | ChEMBL. | 17275313 |
Inhibition (functional) | = 81 % | Growth inhibition of human SF268 cells at 10 uM | ChEMBL. | 17275313 |
Inhibition (functional) | = 105 % | Growth inhibition of human NCI-H460 cells at 10 uM | ChEMBL. | 17275313 |
Inhibition (functional) | = 105 % | Growth inhibition of human NCI-H460 cells at 10 uM | ChEMBL. | 17275313 |
Inhibition (functional) | = 118 % | Growth inhibition of human MCF7 cells at 10 uM | ChEMBL. | 17275313 |
Inhibition (functional) | = 118 % | Growth inhibition of human MCF7 cells at 10 uM | ChEMBL. | 17275313 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.