Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase | 0.0062 | 0.0287 | 0.1045 |
Toxoplasma gondii | NADPH-glutathione reductase | 0.0085 | 0.059 | 0.215 |
Plasmodium vivax | apical sushi protein, putative | 0.0194 | 0.2058 | 0.6819 |
Mycobacterium ulcerans | flavoprotein disulfide reductase | 0.0085 | 0.059 | 0.5 |
Mycobacterium tuberculosis | Probable NADH dehydrogenase Ndh | 0.0124 | 0.111 | 0.2416 |
Echinococcus multilocularis | geminin | 0.0165 | 0.1672 | 0.1672 |
Brugia malayi | pregnancy-associated plasma protein-A | 0.0194 | 0.2058 | 0.7503 |
Loa Loa (eye worm) | hypothetical protein | 0.0194 | 0.2058 | 0.7503 |
Leishmania major | trypanothione reductase | 0.0245 | 0.2743 | 1 |
Echinococcus multilocularis | lysosomal alpha glucosidase | 0.0158 | 0.1568 | 0.1568 |
Onchocerca volvulus | 0.0194 | 0.2058 | 1 | |
Brugia malayi | glutathione reductase | 0.0245 | 0.2743 | 1 |
Brugia malayi | hypothetical protein | 0.0194 | 0.2058 | 0.7503 |
Treponema pallidum | NADH oxidase | 0.0085 | 0.059 | 0.5 |
Wolbachia endosymbiont of Brugia malayi | dihydrolipoamide dehydrogenase E3 component | 0.0085 | 0.059 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0194 | 0.2058 | 0.7503 |
Loa Loa (eye worm) | pregnancy-associated plasma protein-E | 0.0194 | 0.2058 | 0.7503 |
Loa Loa (eye worm) | glutathione reductase | 0.0245 | 0.2743 | 1 |
Brugia malayi | Sushi domain | 0.0194 | 0.2058 | 0.7503 |
Trichomonas vaginalis | glutathione reductase, putative | 0.0085 | 0.059 | 0.5 |
Echinococcus multilocularis | thioredoxin glutathione reductase | 0.0245 | 0.2743 | 0.2743 |
Loa Loa (eye worm) | thioredoxin reductase | 0.0245 | 0.2743 | 1 |
Onchocerca volvulus | 0.0194 | 0.2058 | 1 | |
Mycobacterium leprae | DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE | 0.0186 | 0.1949 | 1 |
Onchocerca volvulus | 0.0091 | 0.0674 | 0.3276 | |
Plasmodium falciparum | thioredoxin reductase | 0.0245 | 0.2743 | 1 |
Echinococcus granulosus | dihydrolipoamide dehydrogenase | 0.0085 | 0.059 | 0.215 |
Loa Loa (eye worm) | hypothetical protein | 0.0194 | 0.2058 | 0.7503 |
Mycobacterium tuberculosis | NADPH-dependent mycothiol reductase Mtr | 0.0245 | 0.2743 | 1 |
Mycobacterium tuberculosis | Probable oxidoreductase | 0.0186 | 0.1949 | 0.6312 |
Brugia malayi | hypothetical protein | 0.0194 | 0.2058 | 0.7503 |
Echinococcus multilocularis | c4b binding protein beta chain | 0.0194 | 0.2058 | 0.2058 |
Onchocerca volvulus | 0.0194 | 0.2058 | 1 | |
Echinococcus multilocularis | dihydrolipoamide dehydrogenase | 0.0085 | 0.059 | 0.059 |
Echinococcus granulosus | C type lectin domian containing protein | 0.0194 | 0.2058 | 0.7503 |
Schistosoma mansoni | hypothetical protein | 0.0165 | 0.1672 | 0.4078 |
Loa Loa (eye worm) | hypothetical protein | 0.0194 | 0.2058 | 0.7503 |
Mycobacterium tuberculosis | Probable reductase | 0.0124 | 0.111 | 0.2416 |
Onchocerca volvulus | 0.0194 | 0.2058 | 1 | |
Loa Loa (eye worm) | hypothetical protein | 0.0216 | 0.2351 | 0.857 |
Toxoplasma gondii | thioredoxin reductase | 0.0245 | 0.2743 | 1 |
Plasmodium falciparum | apical sushi protein | 0.0194 | 0.2058 | 0.6819 |
Mycobacterium tuberculosis | Probable membrane NADH dehydrogenase NdhA | 0.0124 | 0.111 | 0.2416 |
Brugia malayi | hypothetical protein | 0.0194 | 0.2058 | 0.7503 |
Echinococcus granulosus | lysosomal alpha glucosidase | 0.0158 | 0.1568 | 0.5717 |
Toxoplasma gondii | rhoptry neck protein RON9 | 0.0194 | 0.2058 | 0.7503 |
Brugia malayi | hypothetical protein | 0.0194 | 0.2058 | 0.7503 |
Toxoplasma gondii | rhoptry neck protein RON1 | 0.0194 | 0.2058 | 0.7503 |
Trypanosoma brucei | trypanothione reductase | 0.0245 | 0.2743 | 1 |
Schistosoma mansoni | alpha-glucosidase | 0.0136 | 0.1273 | 0.3103 |
Schistosoma mansoni | hypothetical protein | 0.0165 | 0.1672 | 0.4078 |
Echinococcus granulosus | thioredoxin glutathione reductase | 0.0245 | 0.2743 | 1 |
Mycobacterium ulcerans | dihydrolipoamide dehydrogenase, LpdB | 0.0085 | 0.059 | 0.5 |
Onchocerca volvulus | 0.0194 | 0.2058 | 1 | |
Brugia malayi | hypothetical protein | 0.0194 | 0.2058 | 0.7503 |
Echinococcus multilocularis | C type lectin domian containing protein | 0.0194 | 0.2058 | 0.2058 |
Echinococcus granulosus | geminin | 0.0165 | 0.1672 | 0.6098 |
Trypanosoma cruzi | trypanothione reductase, putative | 0.0245 | 0.2743 | 1 |
Onchocerca volvulus | 0.0194 | 0.2058 | 1 | |
Brugia malayi | Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein | 0.0062 | 0.0287 | 0.1045 |
Loa Loa (eye worm) | hypothetical protein | 0.0194 | 0.2058 | 0.7503 |
Loa Loa (eye worm) | hypothetical protein | 0.0235 | 0.261 | 0.9515 |
Plasmodium vivax | thioredoxin reductase, putative | 0.0245 | 0.2743 | 1 |
Onchocerca volvulus | 0.0194 | 0.2058 | 1 | |
Plasmodium falciparum | glutathione reductase | 0.0245 | 0.2743 | 1 |
Brugia malayi | GCC2 and GCC3 family protein | 0.0235 | 0.261 | 0.9515 |
Onchocerca volvulus | 0.0194 | 0.2058 | 1 | |
Brugia malayi | Glycosyl hydrolases family 31 protein | 0.0158 | 0.1568 | 0.5717 |
Loa Loa (eye worm) | hypothetical protein | 0.0194 | 0.2058 | 0.7503 |
Brugia malayi | Thioredoxin reductase | 0.0245 | 0.2743 | 1 |
Schistosoma mansoni | c4b-binding protein beta chain | 0.0194 | 0.2058 | 0.5017 |
Echinococcus granulosus | c4b binding protein beta chain | 0.0194 | 0.2058 | 0.7503 |
Plasmodium vivax | glutathione reductase, putative | 0.0245 | 0.2743 | 1 |
Brugia malayi | hypothetical protein | 0.0194 | 0.2058 | 0.7503 |
Echinococcus multilocularis | lysosomal alpha glucosidase | 0.0158 | 0.1568 | 0.1568 |
Giardia lamblia | NADH oxidase lateral transfer candidate | 0.0085 | 0.059 | 1 |
Mycobacterium tuberculosis | Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB | 0.0124 | 0.111 | 0.2416 |
Schistosoma mansoni | alpha-glucosidase | 0.0136 | 0.1273 | 0.3103 |
Brugia malayi | hypothetical protein | 0.0194 | 0.2058 | 0.7503 |
Mycobacterium tuberculosis | NAD(P)H quinone reductase LpdA | 0.0186 | 0.1949 | 0.6312 |
Onchocerca volvulus | 0.0194 | 0.2058 | 1 | |
Mycobacterium tuberculosis | Putative ferredoxin reductase | 0.0124 | 0.111 | 0.2416 |
Mycobacterium ulcerans | dihydrolipoamide dehydrogenase | 0.0085 | 0.059 | 0.5 |
Mycobacterium tuberculosis | Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras | 0.0186 | 0.1949 | 0.6312 |
Mycobacterium tuberculosis | Probable dehydrogenase | 0.0124 | 0.111 | 0.2416 |
Schistosoma mansoni | dihydrolipoamide dehydrogenase | 0.0085 | 0.059 | 0.1438 |
Chlamydia trachomatis | dihydrolipoyl dehydrogenase | 0.0085 | 0.059 | 0.5 |
Onchocerca volvulus | 0.0194 | 0.2058 | 1 | |
Wolbachia endosymbiont of Brugia malayi | dihydrolipoamide dehydrogenase E3 component | 0.0085 | 0.059 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0194 | 0.2058 | 0.7503 |
Brugia malayi | dihydrolipoyl dehydrogenase, mitochondrial precursor, putative | 0.0085 | 0.059 | 0.215 |
Trichomonas vaginalis | mercuric reductase, putative | 0.0085 | 0.059 | 0.5 |
Loa Loa (eye worm) | glycosyl hydrolase family 31 protein | 0.0158 | 0.1568 | 0.5717 |
Toxoplasma gondii | pyruvate dehydrogenase complex subunit PDH-E3II | 0.0085 | 0.059 | 0.215 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | > 100 uM | Inhibition of Saccharomyces cerevisiae cytoplasmic leucyl-tRNA synthetase assessed as tRNA amino-acylation | ChEMBL. | 17588934 |
IC50 (binding) | > 100 uM | Inhibition of Saccharomyces cerevisiae cytoplasmic leucyl-tRNA synthetase assessed as tRNA amino-acylation | ChEMBL. | 17588934 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.