Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Leishmania major | cytochrome c, putative | 0.0138 | 0.3485 | 1 |
Brugia malayi | Telomerase reverse transcriptase | 0.0224 | 0.6783 | 1 |
Giardia lamblia | Telomerase catalytic subunit | 0.0084 | 0.1439 | 0.5 |
Plasmodium vivax | cytochrome c, putative | 0.0138 | 0.3485 | 1 |
Echinococcus multilocularis | cytochrome c | 0.0138 | 0.3485 | 1 |
Mycobacterium leprae | Probable Ubiquinol-cytochrome C reductase QcrC (cytochrome C subunit) | 0.0047 | 0 | 0.5 |
Plasmodium falciparum | telomerase reverse transcriptase | 0.0084 | 0.1439 | 0.4128 |
Schistosoma mansoni | cytochrome c | 0.0138 | 0.3485 | 1 |
Leishmania major | cytochrome c, putative | 0.0138 | 0.3485 | 1 |
Toxoplasma gondii | RNA-directed DNA polymerase | 0.0084 | 0.1439 | 0.4128 |
Plasmodium vivax | telomerase reverse transcriptase, putative | 0.0084 | 0.1439 | 0.4128 |
Trypanosoma brucei | cytochrome c | 0.0138 | 0.3485 | 1 |
Mycobacterium ulcerans | ubiquinol-cytochrome C reductase QcrC | 0.0047 | 0 | 0.5 |
Trypanosoma cruzi | cytochrome c, putative | 0.0138 | 0.3485 | 1 |
Brugia malayi | Cytochrome c type-1 | 0.0138 | 0.3485 | 0.4538 |
Echinococcus granulosus | cytochrome c | 0.0138 | 0.3485 | 1 |
Plasmodium falciparum | cytochrome c, putative | 0.0138 | 0.3485 | 1 |
Wolbachia endosymbiont of Brugia malayi | cytochrome c2 | 0.0138 | 0.3485 | 0.5 |
Toxoplasma gondii | cytochrome c, putative | 0.0138 | 0.3485 | 1 |
Loa Loa (eye worm) | cytochrome c type-1 | 0.0138 | 0.3485 | 1 |
Trypanosoma cruzi | cytochrome c, putative | 0.0138 | 0.3485 | 1 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.