Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Entamoeba histolytica | chitinase, putative | 0.0172 | 0.5498 | 0.5 |
Brugia malayi | Endochitinase | 0.0192 | 1 | 1 |
Leishmania major | chitinase | 0.0172 | 0.5498 | 0.5 |
Onchocerca volvulus | Putative endochitinase | 0.0192 | 1 | 1 |
Loa Loa (eye worm) | chitinase I | 0.0172 | 0.5498 | 1 |
Loa Loa (eye worm) | cuticular endochitinase | 0.0172 | 0.5498 | 1 |
Mycobacterium tuberculosis | Possible chitinase | 0.0146 | 0 | 0.5 |
Mycobacterium ulcerans | chitinase/cellulase | 0.0146 | 0 | 0.5 |
Onchocerca volvulus | Putative endochitinase | 0.0192 | 1 | 1 |
Loa Loa (eye worm) | microfilarial chitinase | 0.0167 | 0.4502 | 0.8188 |
Mycobacterium ulcerans | chitinase/cellulase | 0.0146 | 0 | 0.5 |
Onchocerca volvulus | Putative endochitinase | 0.0192 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
-log(1/MIC) (functional) | = 3.33 | Antibacterial activity against Bacillus subtilis MTCC 2063 after 24 hrs | ChEMBL. | 17428669 |
-log(1/MIC) (functional) | = 3.33 | Antibacterial activity against Staphylococcus aureus MTCC 290 after 24 hrs | ChEMBL. | 17428669 |
-log(1/MIC) (functional) | = 3.33 | Antibacterial activity against Escherichia coli MTCC 1652 after 24 hrs | ChEMBL. | 17428669 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.