Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Onchocerca volvulus | 0.0112 | 1 | 0.5 | |
Toxoplasma gondii | histone deacetylase HDAC2 | 0.0062 | 0 | 0.5 |
Trichomonas vaginalis | histone deacetylase, putative | 0.0062 | 0 | 0.5 |
Brugia malayi | Inhibitor of Apoptosis domain containing protein | 0.0112 | 1 | 1 |
Trypanosoma cruzi | histone deacetylase 1, putative | 0.0062 | 0 | 0.5 |
Plasmodium falciparum | histone deacetylase 1 | 0.0062 | 0 | 0.5 |
Trichomonas vaginalis | histone deacetylase, putative | 0.0062 | 0 | 0.5 |
Trichomonas vaginalis | histone deacetylase 1, 2 ,3, putative | 0.0062 | 0 | 0.5 |
Plasmodium vivax | histone deacetylase 1, putative | 0.0062 | 0 | 0.5 |
Echinococcus multilocularis | baculoviral IAP repeat containing protein | 0.0112 | 1 | 1 |
Giardia lamblia | Histone deacetylase | 0.0062 | 0 | 0.5 |
Trichomonas vaginalis | histone deacetylase, putative | 0.0062 | 0 | 0.5 |
Toxoplasma gondii | histone deacetylase HDAC3 | 0.0062 | 0 | 0.5 |
Leishmania major | histone deacetylase, putative | 0.0062 | 0 | 0.5 |
Trypanosoma brucei | histone deacetylase 1 | 0.0062 | 0 | 0.5 |
Trypanosoma cruzi | histone deacetylase 1, putative | 0.0062 | 0 | 0.5 |
Schistosoma mansoni | inhibitor of apoptosis protein | 0.0112 | 1 | 1 |
Onchocerca volvulus | Deterin homolog | 0.0112 | 1 | 0.5 |
Trichomonas vaginalis | histone deacetylase 1, 2 ,3, putative | 0.0062 | 0 | 0.5 |
Trichomonas vaginalis | histone deacetylase 1, 2 ,3, putative | 0.0062 | 0 | 0.5 |
Echinococcus multilocularis | inhibitor of apoptosis protein | 0.0112 | 1 | 1 |
Leishmania major | histone deacetylase, putative | 0.0062 | 0 | 0.5 |
Schistosoma mansoni | inhibitor of apoptosis (iap) domain family member | 0.0112 | 1 | 1 |
Entamoeba histolytica | histone deacetylase, putative | 0.0062 | 0 | 0.5 |
Trichomonas vaginalis | histone deacetylase, putative | 0.0062 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0112 | 1 | 1 |
Trichomonas vaginalis | histone deacetylase, putative | 0.0062 | 0 | 0.5 |
Trichomonas vaginalis | histone deacetylase, putative | 0.0062 | 0 | 0.5 |
Echinococcus granulosus | inhibitor of apoptosis protein | 0.0112 | 1 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0112 | 1 | 1 |
Echinococcus granulosus | baculoviral IAP repeat containing protein | 0.0112 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0112 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IZ (functional) | 0 | Antimicrobial activity against Staphylococcus aureus at 400 ug/ml after 48 hrs by disc-diffusion assay | ChEMBL. | 17098426 |
IZ (functional) | 0 | Antimicrobial activity against Salmonella typhi at 400 ug/ml after 48 hrs by disc-diffusion assay | ChEMBL. | 17098426 |
IZ (functional) | = 8 mm | Antimicrobial activity against Bacillus anthracis at 400 ug/ml after 48 hrs by disc-diffusion assay | ChEMBL. | 17098426 |
MIC (functional) | 0 | Antimicrobial activity against Aspergillus fumigatus after 72 hrs by broth dilution assay | ChEMBL. | 17098426 |
MIC (functional) | = 4000 ug ml-1 | Antimicrobial activity against Candida albicans after 72 hrs by broth dilution assay | ChEMBL. | 17098426 |
MIC (functional) | = 4000 ug ml-1 | Antimicrobial activity against Aspergillus niger after 72 hrs by broth dilution assay | ChEMBL. | 17098426 |
MIC (functional) | = 4000 ug ml-1 | Antimicrobial activity against Candida albicans after 72 hrs by broth dilution assay | ChEMBL. | 17098426 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.