Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (functional) | 0 | Antiproliferative activity against human H661 cells at 1 to 25 uM after 48 hrs | ChEMBL. | 17157009 |
Stabilty (ADMET) | 0 | Stability in presence of 100 U/mL Escherichia coli beta-glucuronidase assessed as SAHA production after 7 mins | ChEMBL. | 17157009 |
Stabilty (ADMET) | 0 | Stability in presence of 100 U/mL Escherichia coli beta-glucuronidase assessed as SAHA production after 30 mins | ChEMBL. | 17157009 |
Stabilty (ADMET) | 0 | Stability in presence of 200 to 1000 U/mL bovine liver beta-glucuronisase assessed as SAHA production at 100 ug/mL | ChEMBL. | 17157009 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.