Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Onchocerca volvulus | Peroxidase homolog | 0.0119 | 0 | 0.5 |
Trypanosoma brucei | Polypeptide deformylase 1 | 0.0188 | 0.185 | 0.5 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0119 | 0 | 0.5 |
Onchocerca volvulus | 0.0119 | 0 | 0.5 | |
Loa Loa (eye worm) | hypothetical protein | 0.0119 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0119 | 0 | 0.5 |
Wolbachia endosymbiont of Brugia malayi | peptide deformylase | 0.0492 | 1 | 0.5 |
Onchocerca volvulus | Peroxidasin homolog | 0.0119 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0119 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0119 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0119 | 0 | 0.5 |
Onchocerca volvulus | Dual oxidase homolog | 0.0119 | 0 | 0.5 |
Trypanosoma cruzi | polypeptide deformylase-like protein, putative | 0.0188 | 0.185 | 0.5 |
Onchocerca volvulus | Peroxidase homolog | 0.0119 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0119 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0119 | 0 | 0.5 |
Brugia malayi | Animal haem peroxidase family protein | 0.0119 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0119 | 0 | 0.5 |
Brugia malayi | Blistered cuticle protein 3 | 0.0119 | 0 | 0.5 |
Onchocerca volvulus | 0.0119 | 0 | 0.5 | |
Trypanosoma cruzi | Peptide deformylase 2, putative | 0.0188 | 0.185 | 0.5 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0119 | 0 | 0.5 |
Trypanosoma cruzi | polypeptide deformylase-like protein, putative | 0.0188 | 0.185 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0119 | 0 | 0.5 |
Schistosoma mansoni | peroxidasin | 0.0119 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0119 | 0 | 0.5 |
Echinococcus granulosus | peroxidasin | 0.0119 | 0 | 0.5 |
Mycobacterium leprae | PROBABLE POLYPEPTIDE DEFORMYLASE DEF (PDF) (FORMYLMETHIONINE DEFORMYLASE) | 0.0492 | 1 | 0.5 |
Loa Loa (eye worm) | blistered cuticle protein 3 | 0.0119 | 0 | 0.5 |
Schistosoma mansoni | peroxidasin | 0.0119 | 0 | 0.5 |
Echinococcus multilocularis | peroxidasin | 0.0119 | 0 | 0.5 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0119 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0119 | 0 | 0.5 |
Plasmodium vivax | peptide deformylase, putative | 0.0492 | 1 | 0.5 |
Brugia malayi | Animal haem peroxidase family protein | 0.0119 | 0 | 0.5 |
Onchocerca volvulus | 0.0119 | 0 | 0.5 | |
Loa Loa (eye worm) | animal heme peroxidase | 0.0119 | 0 | 0.5 |
Brugia malayi | Animal haem peroxidase family protein | 0.0119 | 0 | 0.5 |
Brugia malayi | Animal haem peroxidase family protein | 0.0119 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0119 | 0 | 0.5 |
Plasmodium falciparum | peptide deformylase | 0.0492 | 1 | 0.5 |
Brugia malayi | Peroxidasin | 0.0119 | 0 | 0.5 |
Onchocerca volvulus | Chorion peroxidase homolog | 0.0119 | 0 | 0.5 |
Treponema pallidum | polypeptide deformylase (def) | 0.0492 | 1 | 0.5 |
Brugia malayi | hypothetical protein | 0.0119 | 0 | 0.5 |
Mycobacterium tuberculosis | Probable polypeptide deformylase Def (PDF) (formylmethionine deformylase) | 0.0492 | 1 | 0.5 |
Toxoplasma gondii | hypothetical protein | 0.0492 | 1 | 0.5 |
Mycobacterium ulcerans | peptide deformylase | 0.0492 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0119 | 0 | 0.5 |
Onchocerca volvulus | Peroxidasin homolog | 0.0119 | 0 | 0.5 |
Brugia malayi | Animal haem peroxidase family protein | 0.0119 | 0 | 0.5 |
Leishmania major | polypeptide deformylase-like protein, putative | 0.0188 | 0.185 | 0.5 |
Trypanosoma cruzi | Peptide deformylase 2, putative | 0.0188 | 0.185 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0119 | 0 | 0.5 |
Trypanosoma brucei | Peptide deformylase 2 | 0.0188 | 0.185 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Ki (binding) | = 45 uM | Displacement of [3H]dofetilide from human ERG by fliter binding assay | ChEMBL. | 17303420 |
Ki (binding) | = 45 uM | Displacement of [3H]dofetilide from human ERG by fliter binding assay | ChEMBL. | 17303420 |
MIC (functional) | = 0.015 ug ml-1 | Antibacterial activity against Staphylococcus aureus UC76 | ChEMBL. | 17303420 |
MIC (functional) | = 0.015 ug ml-1 | Antibacterial activity against Haemophilus influenzae HI-3542 | ChEMBL. | 17303420 |
MIC (functional) | = 0.03 ug ml-1 | Antibacterial activity against Staphylococcus aureus SA2552 | ChEMBL. | 17303420 |
MIC (functional) | = 0.06 ug ml-1 | Antibacterial activity against Streptococcus pneumoniae SV1 | ChEMBL. | 17303420 |
MIC (functional) | = 0.125 ug ml-1 | Antibacterial activity against Moraxella catarrhalis BC-3531 | ChEMBL. | 17303420 |
MIC (functional) | = 1 ug ml-1 | Antibacterial activity against fluoroquinolone resistance Streptococcus pneumoniae SP3765 | ChEMBL. | 17303420 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.