Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trichomonas vaginalis | voltage and ligand gated potassium channel, putative | 0.0553 | 0.5837 | 0.5 |
Echinococcus multilocularis | glycoprotein Antigen 5 | 0.0398 | 0.1465 | 0.2112 |
Echinococcus multilocularis | fibrillin 1 | 0.045 | 0.2939 | 0.4238 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase | 0.0616 | 0.7607 | 1 |
Mycobacterium tuberculosis | Probable thymidylate synthase ThyA (ts) (TSASE) | 0.0437 | 0.2576 | 0.5 |
Echinococcus multilocularis | laminin | 0.045 | 0.2939 | 0.4238 |
Echinococcus granulosus | thymidylate synthase | 0.0437 | 0.2576 | 0.3715 |
Onchocerca volvulus | 0.0532 | 0.5255 | 0.5255 | |
Brugia malayi | Calcium binding EGF domain containing protein | 0.045 | 0.2939 | 0.2939 |
Echinococcus granulosus | glycoprotein Antigen 5 | 0.0398 | 0.1465 | 0.2112 |
Loa Loa (eye worm) | thymidylate synthase | 0.0437 | 0.2576 | 0.2576 |
Schistosoma mansoni | egf-like domain protein | 0.045 | 0.2939 | 0.2939 |
Loa Loa (eye worm) | hypothetical protein | 0.045 | 0.2939 | 0.2939 |
Trypanosoma brucei | dihydrofolate reductase-thymidylate synthase | 0.0616 | 0.7607 | 0.5 |
Loa Loa (eye worm) | voltage and ligand gated potassium channel | 0.0592 | 0.6935 | 0.6935 |
Loa Loa (eye worm) | hypothetical protein | 0.045 | 0.2939 | 0.2939 |
Echinococcus granulosus | Mastin | 0.0398 | 0.1465 | 0.2112 |
Schistosoma mansoni | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0437 | 0.2576 | 0.2576 |
Echinococcus multilocularis | potassium voltage gated channel subfamily H | 0.0592 | 0.6935 | 1 |
Loa Loa (eye worm) | multiple epidermal growth factor-like domains 6 | 0.045 | 0.2939 | 0.2939 |
Loa Loa (eye worm) | hypothetical protein | 0.045 | 0.2939 | 0.2939 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0646 | 0.8469 | 0.8469 |
Brugia malayi | Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog | 0.0592 | 0.6935 | 0.6935 |
Echinococcus multilocularis | Mastin | 0.0398 | 0.1465 | 0.2112 |
Brugia malayi | Fibulin-1 precursor | 0.045 | 0.2939 | 0.2939 |
Echinococcus multilocularis | Tolloid protein 1 | 0.045 | 0.2939 | 0.4238 |
Plasmodium vivax | bifunctional dihydrofolate reductase-thymidylate synthase, putative | 0.0616 | 0.7607 | 1 |
Mycobacterium ulcerans | thymidylate synthase | 0.0437 | 0.2576 | 0.5 |
Echinococcus granulosus | potassium voltage gated channel subfamily H | 0.0592 | 0.6935 | 1 |
Plasmodium falciparum | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0616 | 0.7607 | 1 |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.0398 | 0.1465 | 0.1465 |
Toxoplasma gondii | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0616 | 0.7607 | 1 |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.0701 | 1 | 1 |
Onchocerca volvulus | 0.0701 | 1 | 1 | |
Schistosoma mansoni | voltage-gated potassium channel | 0.0646 | 0.8469 | 0.8469 |
Loa Loa (eye worm) | hypothetical protein | 0.0701 | 1 | 1 |
Brugia malayi | Low-density lipoprotein receptor repeat class B containing protein | 0.045 | 0.2939 | 0.2939 |
Toxoplasma gondii | calcium binding egf domain-containing protein | 0.045 | 0.2939 | 0.3864 |
Echinococcus granulosus | enteropeptidase | 0.0398 | 0.1465 | 0.2112 |
Loa Loa (eye worm) | low-density lipoprotein receptor repeat class B containing protein | 0.045 | 0.2939 | 0.2939 |
Loa Loa (eye worm) | hypothetical protein | 0.045 | 0.2939 | 0.2939 |
Toxoplasma gondii | calcium binding egf domain-containing protein | 0.045 | 0.2939 | 0.3864 |
Loa Loa (eye worm) | hypothetical protein | 0.0514 | 0.473 | 0.473 |
Brugia malayi | thymidylate synthase | 0.0437 | 0.2576 | 0.2576 |
Loa Loa (eye worm) | hypothetical protein | 0.045 | 0.2939 | 0.2939 |
Echinococcus multilocularis | enteropeptidase | 0.0398 | 0.1465 | 0.2112 |
Onchocerca volvulus | Arrow homolog | 0.045 | 0.2939 | 0.2939 |
Loa Loa (eye worm) | hypothetical protein | 0.0701 | 1 | 1 |
Echinococcus granulosus | laminin | 0.045 | 0.2939 | 0.4238 |
Loa Loa (eye worm) | bone morphogenetic protein 1b | 0.045 | 0.2939 | 0.2939 |
Leishmania major | dihydrofolate reductase-thymidylate synthase | 0.0616 | 0.7607 | 1 |
Echinococcus multilocularis | thymidylate synthase | 0.0437 | 0.2576 | 0.3715 |
Onchocerca volvulus | 0.0437 | 0.2576 | 0.2576 | |
Trichomonas vaginalis | voltage and ligand gated potassium channel, putative | 0.0553 | 0.5837 | 0.5 |
Echinococcus granulosus | Tolloid protein 1 | 0.045 | 0.2939 | 0.4238 |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.0701 | 1 | 1 |
Schistosoma mansoni | subfamily M12A unassigned peptidase (M12 family) | 0.045 | 0.2939 | 0.2939 |
Mycobacterium leprae | PROBABLE THYMIDYLATE SYNTHASE THYA (TS) (TSASE) | 0.0437 | 0.2576 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Inhibition (binding) | = 76 % | Inhibition of human recombinant ATX at 100 uM after 16 hrs | ChEMBL. | 17257836 |
Inhibition (binding) | = 76 % | Inhibition of human recombinant ATX at 100 uM after 16 hrs | ChEMBL. | 17257836 |
Inhibition (binding) | = 97 % | Inhibition of human recombinant ATX at 1 uM after 16 hrs | ChEMBL. | 17257836 |
Inhibition (binding) | = 97 % | Inhibition of human recombinant ATX at 1 uM after 16 hrs | ChEMBL. | 17257836 |
Inhibition (binding) | = 101 % | Inhibition of human recombinant ATX at 10 uM after 16 hrs | ChEMBL. | 17257836 |
Inhibition (binding) | = 101 % | Inhibition of human recombinant ATX at 10 uM after 16 hrs | ChEMBL. | 17257836 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.