Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | kinase | 0.0054 | 0.2022 | 0.2057 |
Brugia malayi | serine/threonine-protein kinase plk-2 | 0.0106 | 0.9828 | 0.9828 |
Loa Loa (eye worm) | low-density lipoprotein receptor repeat class B containing protein | 0.0083 | 0.6304 | 0.5299 |
Echinococcus granulosus | jumonji domain containing protein | 0.0046 | 0.0772 | 0.0772 |
Loa Loa (eye worm) | PLK/PLK1 protein kinase | 0.0106 | 0.9828 | 1 |
Brugia malayi | Calcium binding EGF domain containing protein | 0.0083 | 0.6304 | 0.6304 |
Loa Loa (eye worm) | hypothetical protein | 0.0056 | 0.2353 | 0.0029 |
Leishmania major | protein kinase, putative,polo-like protein kinase, putative | 0.0106 | 0.9828 | 1 |
Echinococcus multilocularis | jumonji domain containing protein | 0.0046 | 0.0772 | 0.0772 |
Echinococcus multilocularis | serine:threonine protein kinase PLK1 | 0.0106 | 0.9828 | 0.9828 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0068 | 0.4158 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0083 | 0.6304 | 0.5299 |
Mycobacterium tuberculosis | Probable aldehyde dehydrogenase | 0.0068 | 0.4158 | 0.5 |
Giardia lamblia | Kinase, PLK | 0.0106 | 0.9828 | 0.5 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.0068 | 0.4158 | 0.4231 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0106 | 0.9828 | 1 |
Toxoplasma gondii | calcium binding egf domain-containing protein | 0.0083 | 0.6304 | 1 |
Trypanosoma cruzi | polo-like protein kinase, putative | 0.0106 | 0.9828 | 0.5 |
Trypanosoma cruzi | polo-like protein kinase, putative | 0.0106 | 0.9828 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0083 | 0.6304 | 0.5299 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0056 | 0.2331 | 0.2331 |
Echinococcus multilocularis | fibrillin 1 | 0.0083 | 0.6304 | 0.6304 |
Echinococcus granulosus | Tolloid protein 1 | 0.0083 | 0.6304 | 0.6304 |
Echinococcus multilocularis | laminin | 0.0083 | 0.6304 | 0.6304 |
Loa Loa (eye worm) | hypothetical protein | 0.0083 | 0.6304 | 0.5299 |
Loa Loa (eye worm) | hypothetical protein | 0.0083 | 0.6304 | 0.5299 |
Echinococcus multilocularis | Transcription factor, JmjC domain containing protein | 0.0108 | 1 | 1 |
Toxoplasma gondii | calcium binding egf domain-containing protein | 0.0083 | 0.6304 | 1 |
Entamoeba histolytica | serine/threonine protein kinase, putative | 0.0106 | 0.9828 | 1 |
Loa Loa (eye worm) | multiple epidermal growth factor-like domains 6 | 0.0083 | 0.6304 | 0.5299 |
Brugia malayi | Low-density lipoprotein receptor repeat class B containing protein | 0.0083 | 0.6304 | 0.6304 |
Loa Loa (eye worm) | bone morphogenetic protein 1b | 0.0083 | 0.6304 | 0.5299 |
Loa Loa (eye worm) | hypothetical protein | 0.0083 | 0.6304 | 0.5299 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0106 | 0.9828 | 1 |
Onchocerca volvulus | Serine\/threonine kinase homolog | 0.0106 | 0.9828 | 1 |
Schistosoma mansoni | jumonji domain containing protein | 0.0086 | 0.6702 | 0.682 |
Echinococcus granulosus | laminin | 0.0083 | 0.6304 | 0.6304 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0106 | 0.9828 | 1 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0106 | 0.9828 | 1 |
Echinococcus multilocularis | Tolloid protein 1 | 0.0083 | 0.6304 | 0.6304 |
Echinococcus granulosus | aldehyde dehydrogenase mitochondrial | 0.0068 | 0.4158 | 0.4158 |
Echinococcus granulosus | Transcription factor JmjC domain containing protein | 0.0108 | 1 | 1 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0106 | 0.9828 | 1 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0068 | 0.4158 | 0.5 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0056 | 0.2331 | 0.2331 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.0068 | 0.4158 | 0.4231 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0106 | 0.9828 | 1 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0106 | 0.9828 | 1 |
Schistosoma mansoni | subfamily M12A unassigned peptidase (M12 family) | 0.0083 | 0.6304 | 0.6415 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0106 | 0.9828 | 1 |
Trypanosoma brucei | polo-like protein kinase | 0.0106 | 0.9828 | 0.5 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0068 | 0.4158 | 0.5 |
Echinococcus multilocularis | aldehyde dehydrogenase, mitochondrial | 0.0068 | 0.4158 | 0.4158 |
Loa Loa (eye worm) | jmjC domain-containing protein | 0.0068 | 0.407 | 0.2319 |
Brugia malayi | Fibulin-1 precursor | 0.0083 | 0.6304 | 0.6304 |
Schistosoma mansoni | egf-like domain protein | 0.0083 | 0.6304 | 0.6415 |
Echinococcus granulosus | serine:threonine protein kinase PLK1 | 0.0106 | 0.9828 | 0.9828 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
CC50 (ADMET) | = 0.0054 mM | Cytotoxicity in human C8166 cells | ChEMBL. | 17574419 |
CC50 (ADMET) | = 0.0054 mM | Cytotoxicity in human C8166 cells | ChEMBL. | 17574419 |
IC50 (binding) | = 0.5534 mM | Inhibition of HIV1 reverse transcriptase | ChEMBL. | 17574419 |
Inhibition (binding) | = 86.35 % | Inhibition of HIV1 reverse transcriptase at 200 ug/mL | ChEMBL. | 17574419 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.