Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | glutamate receptor, ionotropic, N-methyl D-aspartate 1 | Starlite/ChEMBL | References |
Homo sapiens | glutamate receptor, ionotropic, N-methyl D-aspartate 2A | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | nmda type glutamate receptor | 0.0104 | 0.5359 | 0.8137 |
Echinococcus multilocularis | glutamate receptor 2 | 0.0058 | 0.0881 | 0.1379 |
Brugia malayi | Glutamate receptor 2 precursor | 0.0048 | 0 | 0.5 |
Loa Loa (eye worm) | glutamate receptor 2 | 0.0048 | 0 | 0.5 |
Echinococcus granulosus | nmda type glutamate receptor | 0.0113 | 0.6196 | 0.9658 |
Echinococcus multilocularis | glutamate receptor NMDA | 0.0095 | 0.4478 | 0.7015 |
Echinococcus multilocularis | nmda type glutamate receptor | 0.0113 | 0.6196 | 0.9706 |
Schistosoma mansoni | glutamate receptor NMDA | 0.0115 | 0.6384 | 0.6384 |
Echinococcus granulosus | glutamate NMDA receptor subunit | 0.0115 | 0.6384 | 1 |
Echinococcus multilocularis | nmda type glutamate receptor | 0.0104 | 0.5359 | 0.8394 |
Echinococcus multilocularis | glutamate (NMDA) receptor subunit | 0.0115 | 0.6384 | 1 |
Echinococcus multilocularis | Glutamate receptor, ionotropic kainate 2 | 0.0058 | 0.0881 | 0.1379 |
Echinococcus multilocularis | Glutamate receptor, ionotropic kainate 2 | 0.0058 | 0.0881 | 0.1379 |
Echinococcus multilocularis | glutamate receptor, ionotrophic, AMPA 3 | 0.0058 | 0.0881 | 0.1379 |
Loa Loa (eye worm) | glutamate receptor 1 | 0.0048 | 0 | 0.5 |
Brugia malayi | Glutamate receptor 1 precursor | 0.0048 | 0 | 0.5 |
Echinococcus multilocularis | Glutamate receptor, ionotropic kainate 2 | 0.0058 | 0.0881 | 0.1379 |
Echinococcus granulosus | glutamate receptor NMDA | 0.0095 | 0.4478 | 0.6537 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | = 0.078 uM | Antagonist activity at recombinant NR1/NR2A receptor expressed in Xenopus laevis oocytes | ChEMBL. | 17624774 |
IC50 (functional) | = 0.078 uM | Antagonist activity at recombinant NR1/NR2A receptor expressed in Xenopus laevis oocytes | ChEMBL. | 17624774 |
IC50 (functional) | = 0.108 uM | Antagonist activity at recombinant NR1/NR2B receptor expressed in Xenopus laevis oocytes | ChEMBL. | 17624774 |
IC50 (functional) | = 0.108 uM | Antagonist activity at recombinant NR1/NR2B receptor expressed in Xenopus laevis oocytes | ChEMBL. | 17624774 |
IC50 (functional) | = 32.5 uM | Cytotoxicity in mouse FM3A cells after 48 hrs | ChEMBL. | 17624774 |
IC50 (functional) | = 32.5 uM | Cytotoxicity in mouse FM3A cells after 48 hrs | ChEMBL. | 17624774 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.