Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | kinesin family member 11 | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trichomonas vaginalis | mercuric reductase, putative | 0.0044 | 0.0529 | 0.5 |
Leishmania major | trypanothione reductase | 0.0126 | 0.4342 | 1 |
Brugia malayi | dihydrolipoyl dehydrogenase, mitochondrial precursor, putative | 0.0044 | 0.0529 | 0.1218 |
Toxoplasma gondii | thioredoxin reductase | 0.0126 | 0.4342 | 1 |
Echinococcus multilocularis | kinesin family 1 | 0.0247 | 1 | 1 |
Loa Loa (eye worm) | thioredoxin reductase | 0.0126 | 0.4342 | 1 |
Mycobacterium leprae | DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE | 0.0044 | 0.0529 | 0.5 |
Wolbachia endosymbiont of Brugia malayi | dihydrolipoamide dehydrogenase E3 component | 0.0044 | 0.0529 | 0.5 |
Mycobacterium ulcerans | dihydrolipoamide dehydrogenase | 0.0044 | 0.0529 | 0.5 |
Plasmodium vivax | dihydrolipoyl dehydrogenase, apicoplast, putative | 0.0044 | 0.0529 | 0.1218 |
Schistosoma mansoni | dihydrolipoamide dehydrogenase | 0.0044 | 0.0529 | 0.0622 |
Trypanosoma cruzi | trypanothione reductase, putative | 0.0126 | 0.4342 | 1 |
Wolbachia endosymbiont of Brugia malayi | dihydrolipoamide dehydrogenase E3 component | 0.0044 | 0.0529 | 0.5 |
Giardia lamblia | NADH oxidase lateral transfer candidate | 0.0044 | 0.0529 | 1 |
Echinococcus granulosus | thioredoxin glutathione reductase | 0.0126 | 0.4342 | 0.4026 |
Trypanosoma brucei | trypanothione reductase | 0.0126 | 0.4342 | 1 |
Brugia malayi | glutathione reductase | 0.0126 | 0.4342 | 1 |
Plasmodium vivax | dihydrolipoyl dehydrogenase, mitochondrial, putative | 0.0044 | 0.0529 | 0.1218 |
Plasmodium falciparum | dihydrolipoyl dehydrogenase, mitochondrial | 0.0044 | 0.0529 | 0.1218 |
Mycobacterium ulcerans | flavoprotein disulfide reductase | 0.0044 | 0.0529 | 0.5 |
Plasmodium vivax | thioredoxin reductase, putative | 0.0126 | 0.4342 | 1 |
Plasmodium falciparum | dihydrolipoyl dehydrogenase, apicoplast | 0.0044 | 0.0529 | 0.1218 |
Schistosoma mansoni | hypothetical protein | 0.0215 | 0.8507 | 1 |
Plasmodium falciparum | glutathione reductase | 0.0126 | 0.4342 | 1 |
Trichomonas vaginalis | glutathione reductase, putative | 0.0044 | 0.0529 | 0.5 |
Echinococcus multilocularis | thioredoxin glutathione reductase | 0.0126 | 0.4342 | 0.4026 |
Entamoeba histolytica | kinesin, putative | 0.0032 | 0 | 0.5 |
Loa Loa (eye worm) | glutathione reductase | 0.0126 | 0.4342 | 1 |
Toxoplasma gondii | pyruvate dehydrogenase complex subunit PDH-E3II | 0.0044 | 0.0529 | 0.1218 |
Plasmodium falciparum | glutathione reductase | 0.0044 | 0.0529 | 0.1218 |
Brugia malayi | Thioredoxin reductase | 0.0126 | 0.4342 | 1 |
Plasmodium vivax | glutathione reductase, putative | 0.0126 | 0.4342 | 1 |
Plasmodium falciparum | thioredoxin reductase | 0.0126 | 0.4342 | 1 |
Treponema pallidum | NADH oxidase | 0.0044 | 0.0529 | 0.5 |
Mycobacterium ulcerans | dihydrolipoamide dehydrogenase, LpdB | 0.0044 | 0.0529 | 0.5 |
Mycobacterium tuberculosis | NADPH-dependent mycothiol reductase Mtr | 0.0126 | 0.4342 | 1 |
Plasmodium falciparum | thioredoxin reductase | 0.0044 | 0.0529 | 0.1218 |
Chlamydia trachomatis | dihydrolipoyl dehydrogenase | 0.0044 | 0.0529 | 0.5 |
Toxoplasma gondii | NADPH-glutathione reductase | 0.0044 | 0.0529 | 0.1218 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
EC50 (binding) | = 5.8 uM | Inhibition of KSP in A549 cells assessed by MPM-2 cytoblot assay | ChEMBL. | 17498954 |
EC50 (binding) | = 5.8 uM | Inhibition of KSP in A549 cells assessed by MPM-2 cytoblot assay | ChEMBL. | 17498954 |
EC50 (functional) | = 13 uM | Cytotoxicity against A549 cells after 60 hrs | ChEMBL. | 17498954 |
EC50 (functional) | = 13 uM | Cytotoxicity against A549 cells after 60 hrs | ChEMBL. | 17498954 |
IC50 (binding) | = 4.1 uM | Inhibition of human KSP expressed in Escherichia coli assessed by ATPase assay | ChEMBL. | 17498954 |
IC50 (binding) | = 4.1 uM | Inhibition of human KSP expressed in Escherichia coli assessed by ATPase assay | ChEMBL. | 17498954 |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Homo sapiens | ChEMBL23 | 17498954 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.