Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | kinesin family member 11 | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | glycogen phosphorylase | 0.0108 | 0.4206 | 0.4206 |
Entamoeba histolytica | glycogenphosphorylase, putative | 0.0047 | 0.1645 | 0.1929 |
Schistosoma mansoni | glycogen phosphorylase | 0.0108 | 0.4206 | 0.4856 |
Loa Loa (eye worm) | kinesin-like protein KLP2 | 0.0032 | 0.1033 | 0.2455 |
Echinococcus granulosus | glycogen phosphorylase | 0.0108 | 0.4206 | 0.4206 |
Echinococcus multilocularis | Glycosyl transferase, family 35 | 0.0108 | 0.4206 | 0.4206 |
Entamoeba histolytica | glycogen phosphorylase, putative | 0.0047 | 0.1645 | 0.1929 |
Brugia malayi | Kinesin motor domain containing protein | 0.0032 | 0.1033 | 0.2455 |
Onchocerca volvulus | Glycogen phosphorylase homolog | 0.0108 | 0.4206 | 1 |
Entamoeba histolytica | glycogen phosphorylase, putative | 0.0047 | 0.1645 | 0.1929 |
Trichomonas vaginalis | glycogen phosphorylase, putative | 0.0108 | 0.4206 | 0.5 |
Mycobacterium tuberculosis | Probable glycogen phosphorylase GlgP | 0.0047 | 0.1645 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0215 | 0.8661 | 1 |
Schistosoma mansoni | glycogen phosphorylase | 0.0047 | 0.1645 | 0.1899 |
Schistosoma mansoni | glycogen phosphorylase | 0.0108 | 0.4206 | 0.4856 |
Echinococcus granulosus | glycogen phosphorylase | 0.0108 | 0.4206 | 0.4206 |
Echinococcus multilocularis | kinesin family 1 | 0.0247 | 1 | 1 |
Plasmodium falciparum | kinesin-5 | 0.0032 | 0.1033 | 0.5 |
Giardia lamblia | Glycogen phosphorylase | 0.0108 | 0.4206 | 1 |
Loa Loa (eye worm) | glycogen phosphorylase | 0.0108 | 0.4206 | 1 |
Entamoeba histolytica | glycogen phosphorylase, putative | 0.0108 | 0.4206 | 1 |
Toxoplasma gondii | kinesin motor domain-containing protein | 0.0032 | 0.1033 | 0.5 |
Echinococcus granulosus | Glycosyl transferase family 35 | 0.0108 | 0.4206 | 0.4206 |
Chlamydia trachomatis | glycogen phosphorylase | 0.0108 | 0.4206 | 0.5 |
Echinococcus multilocularis | glycogen phosphorylase | 0.0108 | 0.4206 | 0.4206 |
Mycobacterium ulcerans | glycogen phosphorylase GlgP | 0.0047 | 0.1645 | 0.5 |
Trichomonas vaginalis | glycogen phosphorylase, putative | 0.0108 | 0.4206 | 0.5 |
Entamoeba histolytica | glycogen phosphorylase, putative | 0.0108 | 0.4206 | 1 |
Schistosoma mansoni | kinesin eg-5 | 0.0032 | 0.1033 | 0.1192 |
Plasmodium vivax | kinesin-5 | 0.0032 | 0.1033 | 0.5 |
Brugia malayi | carbohydrate phosphorylase | 0.0108 | 0.4206 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
EC50 (binding) | = 7.6 uM | Inhibition of KSP in A549 cells assessed by MPM-2 cytoblot assay | ChEMBL. | 17498954 |
EC50 (binding) | = 7.6 uM | Inhibition of KSP in A549 cells assessed by MPM-2 cytoblot assay | ChEMBL. | 17498954 |
EC50 (functional) | > 30 uM | Cytotoxicity against A549 cells after 60 hrs | ChEMBL. | 17498954 |
EC50 (functional) | > 30 uM | Cytotoxicity against A549 cells after 60 hrs | ChEMBL. | 17498954 |
IC50 (binding) | = 8.6 uM | Inhibition of human KSP expressed in Escherichia coli assessed by ATPase assay | ChEMBL. | 17498954 |
IC50 (binding) | = 8.6 uM | Inhibition of human KSP expressed in Escherichia coli assessed by ATPase assay | ChEMBL. | 17498954 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.