Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Giardia lamblia | Glycogen phosphorylase | 0.0911 | 0.5 | 0.5 |
Loa Loa (eye worm) | glycogen phosphorylase | 0.0911 | 0.5 | 0.5 |
Echinococcus multilocularis | glycogen phosphorylase | 0.0911 | 0.5 | 0.5 |
Trichomonas vaginalis | glycogen phosphorylase, putative | 0.0911 | 0.5 | 0.5 |
Echinococcus granulosus | glycogen phosphorylase | 0.0911 | 0.5 | 0.5 |
Echinococcus multilocularis | Glycosyl transferase, family 35 | 0.0911 | 0.5 | 0.5 |
Entamoeba histolytica | glycogen phosphorylase, putative | 0.0911 | 0.5 | 0.5 |
Chlamydia trachomatis | glycogen phosphorylase | 0.0911 | 0.5 | 0.5 |
Echinococcus granulosus | glycogen phosphorylase | 0.0911 | 0.5 | 0.5 |
Entamoeba histolytica | glycogen phosphorylase, putative | 0.0911 | 0.5 | 0.5 |
Schistosoma mansoni | glycogen phosphorylase | 0.0911 | 0.5 | 0.5 |
Trichomonas vaginalis | glycogen phosphorylase, putative | 0.0911 | 0.5 | 0.5 |
Echinococcus multilocularis | glycogen phosphorylase | 0.0911 | 0.5 | 0.5 |
Onchocerca volvulus | Glycogen phosphorylase homolog | 0.0911 | 0.5 | 0.5 |
Schistosoma mansoni | glycogen phosphorylase | 0.0911 | 0.5 | 0.5 |
Echinococcus granulosus | Glycosyl transferase family 35 | 0.0911 | 0.5 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (functional) | 0 | Cytotoxicity against human A549 cells | ChEMBL. | 17643301 |
Activity (functional) | 0 | Cytotoxicity against human HCT8 cells | ChEMBL. | 17643301 |
Activity (functional) | 0 | Cytotoxicity against MDR human KB-VIN cells expressing P-glycoprotein | ChEMBL. | 17643301 |
Activity (functional) | 0 | Cytotoxicity against human 1A9 cells by sulforhodamine B assay | ChEMBL. | 17643301 |
Activity (functional) | 0 | Cytotoxicity against human KB cells by sulforhodamine B assay | ChEMBL. | 17643301 |
ED50 (functional) | = 0.1 ug ml-1 | Cytotoxicity against human A431 cells | ChEMBL. | 17643301 |
ED50 (functional) | = 0.1 ug ml-1 | Cytotoxicity against human A431 cells | ChEMBL. | 17643301 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.