Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) | Starlite/ChEMBL | References |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (ADMET) | = 18 ug/g | Drug level in Sprague-Dawley rat liver after 1 hr | ChEMBL. | 17070047 |
Inhibition (functional) | = 9 % | Inhibition of prednisolone-induced lymphopenia in Sprague-Dawley rats at 100 mg/kg, po | ChEMBL. | 17070047 |
Inhibition (functional) | = 72 % | Inhibition of prednisolone-induced TAT level in Sprague-Dawley rats at 100 mg/kg, po | ChEMBL. | 17070047 |
Inhibition (functional) | = 86 % | Inhibition of prednisolone-induced glycoegen depostion in Sprague-Dawley rats at 100 mg/kg, po | ChEMBL. | 17070047 |
Ki (binding) | = 4 nM | Displacement of radiolabelled dexamethasone from human GR | ChEMBL. | 17070047 |
Ki (binding) | = 4 nM | Displacement of radiolabelled dexamethasone from human GR | ChEMBL. | 17070047 |
Ki (binding) | = 15 nM | Inhibition of human GR expressed in hGRAF cells | ChEMBL. | 17070047 |
Ki (binding) | = 15 nM | Inhibition of human GR expressed in hGRAF cells | ChEMBL. | 17070047 |
Ki (binding) | = 200 nM | Inhibition of human GR transcriptional activation by HepTAT cells | ChEMBL. | 17070047 |
Ki (binding) | = 200 nM | Inhibition of human GR transcriptional activation by HepTAT cells | ChEMBL. | 17070047 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.