Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Toxoplasma gondii | aminopeptidase n, putative | 0.0321 | 1 | 0.5 |
Onchocerca volvulus | Matrix metalloproteinase homolog | 0.005 | 0.0623 | 1 |
Onchocerca volvulus | Matrilysin homolog | 0.005 | 0.0623 | 1 |
Toxoplasma gondii | aminopeptidase N protein | 0.0321 | 1 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0032 | 0 | 0.5 |
Loa Loa (eye worm) | matrixin family protein | 0.0054 | 0.0778 | 1 |
Toxoplasma gondii | aminopeptidase N, putative | 0.0321 | 1 | 0.5 |
Echinococcus granulosus | matrix metallopeptidase 7 M10 family | 0.0082 | 0.1726 | 0.5 |
Plasmodium vivax | M1-family alanyl aminopeptidase, putative | 0.0321 | 1 | 0.5 |
Brugia malayi | Matrixin family protein | 0.0054 | 0.0778 | 1 |
Echinococcus multilocularis | matrix metallopeptidase 7 (M10 family) | 0.0082 | 0.1726 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 99 uM | Inhibition of recombinant GST-tagged SIRT2 by Fluor de Lys fluorescence assay | ChEMBL. | 18701307 |
IC50 (binding) | = 99 umol/L | Inhibition of SIRT2 | ChEMBL. | 17329104 |
IC50 (binding) | = 99 umol/L | Inhibition of SIRT2 | ChEMBL. | 17329104 |
Inhibition (binding) | = 10.3 % | Inhibition of SIRT1 at 200 uM | ChEMBL. | 17329104 |
Inhibition (binding) | = 10.3 % | Inhibition of SIRT1 at 200 uM | ChEMBL. | 17329104 |
Inhibition (binding) | = 55.4 % | Inhibition of SIRT2 at 200 uM | ChEMBL. | 17329104 |
Inhibition (binding) | = 55.4 % | Inhibition of SIRT2 at 200 uM | ChEMBL. | 17329104 |
Inhibition (binding) | = 55.4 % | Inhibition of recombinant GST-tagged SIRT2 at 200 uM by Fluor de Lys fluorescence assay | ChEMBL. | 18701307 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
2 literature references were collected for this gene.