Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | solute carrier family 29 (equilibrative nucleoside transporter), member 1 | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Trypanosoma brucei | purine nucleoside transporter | solute carrier family 29 (equilibrative nucleoside transporter), member 1 | 456 aa | 396 aa | 24.8 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0098 | 1 | 0.5 |
Echinococcus multilocularis | equilibrative nucleoside transporter 3 | 0.0098 | 1 | 1 |
Onchocerca volvulus | Equilibrative nucleoside transporter, putative homolog | 0.0098 | 1 | 0.5 |
Trichomonas vaginalis | equilibrative nucleoside transporter, putative | 0.0098 | 1 | 0.5 |
Echinococcus granulosus | equilibrative nucleoside transporter | 0.0098 | 1 | 0.5 |
Trichomonas vaginalis | equilibrative nucleoside transporter, putative | 0.0098 | 1 | 0.5 |
Trichomonas vaginalis | equilibrative nucleoside transporter, putative | 0.0098 | 1 | 0.5 |
Entamoeba histolytica | nucleoside transporter, putative | 0.0098 | 1 | 0.5 |
Onchocerca volvulus | Equilibrative nucleoside transporter, putative homolog | 0.0098 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0098 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0098 | 1 | 0.5 |
Trichomonas vaginalis | equilibrative nucleoside transporter, putative | 0.0098 | 1 | 0.5 |
Echinococcus granulosus | equilibrative nucleoside transporter 3 | 0.0098 | 1 | 0.5 |
Giardia lamblia | Hypothetical protein | 0.0098 | 1 | 0.5 |
Brugia malayi | hypothetical protein | 0.0098 | 1 | 0.5 |
Echinococcus multilocularis | equilibrative nucleoside transporter protein | 0.0098 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 672 nM | Inhibition of ENT1 in human K562 cells by flow cytometric assay | ChEMBL. | 17636949 |
IC50 (binding) | = 672 nM | Inhibition of ENT1 in human K562 cells by flow cytometric assay | ChEMBL. | 17636949 |
Inhibition (binding) | = 69.3 % | Inhibition of ENT1 in human K562 cells at 10 uM by flow cytometric assay | ChEMBL. | 17636949 |
Inhibition (binding) | = 69.3 % | Inhibition of ENT1 in human K562 cells at 10 uM by flow cytometric assay | ChEMBL. | 17636949 |
Ki (binding) | = 38 nM | Inhibition of ENT1 in human K562 cells by flow cytometric assay | ChEMBL. | 17636949 |
Ki (binding) | = 38 nM | Inhibition of ENT1 in human K562 cells by flow cytometric assay | ChEMBL. | 17636949 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.