Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | checkpoint kinase 1 | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Schistosoma japonicum | Serine/threonine-protein kinase Chk1, putative | Get druggable targets OG5_130454 | All targets in OG5_130454 |
Brugia malayi | Protein kinase domain containing protein | Get druggable targets OG5_130454 | All targets in OG5_130454 |
Schistosoma mansoni | serine/threonine protein kinase | Get druggable targets OG5_130454 | All targets in OG5_130454 |
Loa Loa (eye worm) | CAMK/CAMKL/CHK1 protein kinase | Get druggable targets OG5_130454 | All targets in OG5_130454 |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Plasmodium falciparum | nitric oxide synthase, putative | 0.0503 | 1 | 0.5 |
Loa Loa (eye worm) | FAD binding domain-containing protein | 0.0503 | 1 | 1 |
Toxoplasma gondii | flavodoxin domain-containing protein | 0.0249 | 0.1574 | 0.5 |
Giardia lamblia | Nitric oxide synthase, inducible | 0.0445 | 0.8099 | 0.5 |
Loa Loa (eye worm) | FAD binding domain-containing protein | 0.031 | 0.3602 | 0.3602 |
Schistosoma mansoni | diflavin oxidoreductase | 0.0249 | 0.1574 | 0.1574 |
Leishmania major | NADPH-cytochrome p450 reductase-like protein | 0.0503 | 1 | 1 |
Trypanosoma cruzi | NADPH-dependent FMN/FAD containing oxidoreductase, putative | 0.0503 | 1 | 0.5 |
Trypanosoma cruzi | cytochrome P450 reductase, putative | 0.0503 | 1 | 0.5 |
Giardia lamblia | Hypothetical protein | 0.0445 | 0.8099 | 0.5 |
Chlamydia trachomatis | sulfite reductase | 0.031 | 0.3602 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0503 | 1 | 1 |
Trypanosoma brucei | NADPH-dependent diflavin oxidoreductase 1 | 0.0503 | 1 | 0.5 |
Trypanosoma brucei | NADPH--cytochrome P450 reductase, putative | 0.0503 | 1 | 0.5 |
Leishmania major | p450 reductase, putative | 0.0503 | 1 | 1 |
Trypanosoma cruzi | p450 reductase, putative | 0.0503 | 1 | 0.5 |
Brugia malayi | FAD binding domain containing protein | 0.031 | 0.3602 | 0.3602 |
Echinococcus granulosus | NADPH dependent diflavin oxidoreductase 1 | 0.0503 | 1 | 1 |
Echinococcus granulosus | NADPH cytochrome P450 reductase | 0.0503 | 1 | 1 |
Trypanosoma cruzi | cytochrome P450 reductase, putative | 0.0503 | 1 | 0.5 |
Echinococcus multilocularis | NADPH dependent diflavin oxidoreductase 1 | 0.0503 | 1 | 1 |
Trichomonas vaginalis | sulfite reductase, putative | 0.0503 | 1 | 1 |
Plasmodium vivax | NADPH-cytochrome p450 reductase, putative | 0.0503 | 1 | 1 |
Schistosoma mansoni | NADPH flavin oxidoreductase | 0.0253 | 0.1701 | 0.1701 |
Mycobacterium ulcerans | formate dehydrogenase H FdhF | 0.0503 | 1 | 0.5 |
Trypanosoma brucei | NADPH-cytochrome p450 reductase, putative | 0.0503 | 1 | 0.5 |
Schistosoma mansoni | cytochrome P450 reductase | 0.0503 | 1 | 1 |
Trypanosoma brucei | NADPH--cytochrome P450 reductase, putative | 0.0503 | 1 | 0.5 |
Brugia malayi | FAD binding domain containing protein | 0.0503 | 1 | 1 |
Echinococcus multilocularis | NADPH cytochrome P450 reductase | 0.0503 | 1 | 1 |
Toxoplasma gondii | flavodoxin domain-containing protein | 0.0249 | 0.1574 | 0.5 |
Schistosoma mansoni | 5-methyl tetrahydrofolate-homocysteine methyltransferase reductase | 0.031 | 0.3602 | 0.3602 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.