Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Staphylococcus aureus | Penicillin-binding protein 2a | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Treponema pallidum | penicillin-binding protein (pbp-1) | Get druggable targets OG5_133524 | All targets in OG5_133524 |
Mycobacterium leprae | Probable penicillin-binding protein PbpA | Get druggable targets OG5_133524 | All targets in OG5_133524 |
Mycobacterium ulcerans | penicillin-binding protein PbpA | Get druggable targets OG5_133524 | All targets in OG5_133524 |
Chlamydia trachomatis | transglycolase/transpeptidase | Get druggable targets OG5_133524 | All targets in OG5_133524 |
Wolbachia endosymbiont of Brugia malayi | cell division protein FtsI | Get druggable targets OG5_133524 | All targets in OG5_133524 |
Mycobacterium tuberculosis | Probable penicillin-binding protein PbpA | Get druggable targets OG5_133524 | All targets in OG5_133524 |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.0521 | 1 | 1 |
Onchocerca volvulus | 0.0466 | 0.852 | 0.852 | |
Loa Loa (eye worm) | hypothetical protein | 0.0521 | 1 | 1 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0147 | 0 | 0.5 |
Treponema pallidum | penicillin-binding protein (pbp-1) | 0.0376 | 0.6128 | 1 |
Wolbachia endosymbiont of Brugia malayi | cell division protein FtsI | 0.0376 | 0.6128 | 0.5 |
Loa Loa (eye worm) | STAT protein | 0.0221 | 0.198 | 0.198 |
Mycobacterium ulcerans | penicillin-binding lipoprotein | 0.0371 | 0.599 | 1 |
Mycobacterium ulcerans | penicillin-binding protein PbpA | 0.0251 | 0.2789 | 0.4101 |
Toxoplasma gondii | kringle domain-containing protein | 0.0147 | 0 | 0.5 |
Leishmania major | hypothetical protein, conserved | 0.0147 | 0 | 0.5 |
Chlamydia trachomatis | transglycolase/transpeptidase | 0.0376 | 0.6128 | 0.5 |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.0521 | 1 | 1 |
Echinococcus multilocularis | tissue type plasminogen activator | 0.0147 | 0 | 0.5 |
Plasmodium falciparum | cysteine repeat modular protein 1 | 0.0147 | 0 | 0.5 |
Mycobacterium tuberculosis | Possible penicillin-binding lipoprotein | 0.0371 | 0.599 | 1 |
Brugia malayi | STAT protein, DNA binding domain containing protein | 0.0221 | 0.198 | 0.198 |
Onchocerca volvulus | 0.0521 | 1 | 1 | |
Mycobacterium leprae | POSSIBLE PENICILLIN-BINDING LIPOPROTEIN | 0.0371 | 0.599 | 1 |
Echinococcus granulosus | tissue type plasminogen activator | 0.0147 | 0 | 0.5 |
Plasmodium vivax | cysteine repeat modular protein 1, putative | 0.0147 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0521 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 4.7 ug ml-1 | Binding affinity towards Penicillin-binding protein 2a from homogeneous MRSA COL strain using [3H]-radioligand | ChEMBL. | No reference |
IC50 (binding) | = 4.7 ug ml-1 | Binding affinity towards Penicillin-binding protein 2a from homogeneous MRSA COL strain using [3H]-radioligand | ChEMBL. | No reference |
MIC (functional) | = 0.1 ug ml-1 | Inhibitory activity against methicillin-sensitive staphylococcus aureus(MSSA) | ChEMBL. | No reference |
MIC (functional) | = 4 ug ml-1 | Inhibitory activity against methicillin-resistant staphylococcus aureus(MRSA) | ChEMBL. | No reference |
MIC (functional) | = 6 ug ml-1 | Inhibitory activity against enterococcus evaluated by computational method | ChEMBL. | No reference |
MIC (functional) | = 7.1 ug ml-1 | Inhibitory activity against methicillin-resistant coagulase negative staphylococci (MRCNS) | ChEMBL. | No reference |
MIC (functional) | = 31.6 ug ml-1 | The gram-negative activity is derived from eleven strains selected from seven enteric genera | ChEMBL. | No reference |
Susceptibility (binding) | = 0.3 | Compound was evaluated for susceptibility to DHP-I (swine kidney enzyme) | ChEMBL. | No reference |
Susceptibility (binding) | = 0.3 | Compound was evaluated for susceptibility to DHP-I (swine kidney enzyme) | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.