Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | bradykinin receptor B1 | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Entamoeba histolytica | tagatose-6-phosphate kinase, putative | 0.026 | 0 | 0.5 |
Entamoeba histolytica | fructokinase, putative | 0.026 | 0 | 0.5 |
Onchocerca volvulus | 0.2021 | 0.8714 | 1 | |
Toxoplasma gondii | kinase, pfkB family protein | 0.2281 | 1 | 1 |
Mycobacterium tuberculosis | Ribokinase RbsK | 0.026 | 0 | 0.5 |
Trypanosoma brucei | RNA helicase, putative | 0.1712 | 0.7182 | 0.7182 |
Schistosoma mansoni | adenosine kinase | 0.2281 | 1 | 1 |
Trichomonas vaginalis | ribokinase, putative | 0.026 | 0 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.1712 | 0.7182 | 0.7182 |
Trypanosoma brucei | adenosine kinase, putative | 0.2281 | 1 | 1 |
Mycobacterium ulcerans | fructokinase, PfkB | 0.026 | 0 | 0.5 |
Entamoeba histolytica | kinase, PfkB family | 0.026 | 0 | 0.5 |
Leishmania major | adenosine kinase, putative | 0.2281 | 1 | 1 |
Trypanosoma brucei | adenosine kinase, putative | 0.2281 | 1 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.026 | 0 | 0.5 |
Echinococcus multilocularis | adenosine kinase | 0.2281 | 1 | 1 |
Trichomonas vaginalis | ribokinase, putative | 0.026 | 0 | 0.5 |
Schistosoma mansoni | adenosine kinase | 0.2281 | 1 | 1 |
Trichomonas vaginalis | ribokinase, putative | 0.026 | 0 | 0.5 |
Mycobacterium tuberculosis | 6-phosphofructokinase PfkB (phosphohexokinase) (phosphofructokinase) | 0.026 | 0 | 0.5 |
Trypanosoma cruzi | adenosine kinase, putative | 0.2281 | 1 | 1 |
Entamoeba histolytica | ribokinase, putative | 0.026 | 0 | 0.5 |
Mycobacterium leprae | Probable adenosine kinase adk | 0.026 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.2281 | 1 | 1 |
Mycobacterium tuberculosis | Adenosine kinase | 0.026 | 0 | 0.5 |
Mycobacterium ulcerans | carbohydrate kinase CbhK | 0.026 | 0 | 0.5 |
Giardia lamblia | Ribokinase | 0.026 | 0 | 0.5 |
Trypanosoma cruzi | adenosine kinase, putative | 0.2281 | 1 | 1 |
Entamoeba histolytica | Hypothetical protein T24C12.3, putative | 0.026 | 0 | 0.5 |
Echinococcus granulosus | adenosine kinase | 0.2281 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | = 12 nM | Antagonist activity at human bradykinin B1 receptor in IL1beta stimulated IMR90 cells by FLIPR assay | ChEMBL. | 17880055 |
IC50 (functional) | = 12 nM | Antagonist activity at human bradykinin B1 receptor in IL1beta stimulated IMR90 cells by FLIPR assay | ChEMBL. | 17880055 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.