Detailed information for compound 434688

Basic information

Technical information
  • TDR Targets ID: 434688
  • Name: (2-bromophenyl)-pyrazol-1-ylmethanone
  • MW: 251.079 | Formula: C10H7BrN2O
  • H donors: 0 H acceptors: 2 LogP: 2.46 Rotable bonds: 2
    Rule of 5 violations (Lipinski): 1
  • SMILES: Brc1ccccc1C(=O)n1cccn1
  • InChi: 1S/C10H7BrN2O/c11-9-5-2-1-4-8(9)10(14)13-7-3-6-12-13/h1-7H
  • InChiKey: JDDYZNBYEUVUHO-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • (2-bromophenyl)-pyrazol-1-yl-methanone
  • (2-bromophenyl)-(1-pyrazolyl)methanone
  • ZINC02859946
  • BAS 02052873
  • (2-Bromo-phenyl)-pyrazol-1-yl-methanone
  • A2038/0085638

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis subfamily M14A unassigned peptidase 0.0085 0.008 0.0005
Schistosoma mansoni neuropeptide f receptor 76f 0.0251 0.0989 0.2978
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0104 0.0184 0.4886
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0138 0.0369 1
Echinococcus granulosus neuropeptides capa receptor 0.0251 0.0989 0.2978
Onchocerca volvulus 0.0251 0.0989 1
Echinococcus multilocularis somatostatin receptor 0.0251 0.0989 0.2978
Echinococcus multilocularis fmrfamide receptor 0.0251 0.0989 0.2978
Onchocerca volvulus 0.0251 0.0989 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0251 0.0989 0.2978
Loa Loa (eye worm) hypothetical protein 0.0251 0.0989 0.3153
Loa Loa (eye worm) cyclic AMP specific phosphodiesterase PDE4D5A 0.0559 0.2673 0.8519
Trichomonas vaginalis cone cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0138 0.0369 1
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0251 0.0989 0.2978
Brugia malayi sulfakinin receptor protein 0.0251 0.0989 0.3511
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0251 0.0989 0.2978
Echinococcus granulosus neuropeptide receptor A26 0.0251 0.0989 0.2978
Echinococcus granulosus rhodopsin orphan GPCR 0.0251 0.0989 0.2978
Onchocerca volvulus 0.0251 0.0989 1
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0251 0.0989 1
Loa Loa (eye worm) hypothetical protein 0.0251 0.0989 0.3153
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0138 0.0369 1
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0251 0.0989 0.2978
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0085 0.0079 0.1969
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0251 0.0989 0.3511
Echinococcus granulosus fmrfamide receptor 0.0251 0.0989 0.2978
Echinococcus granulosus cAMP specific 3'5' cyclic phosphodiesterase 0.0559 0.2673 0.8481
Echinococcus granulosus neuropeptide FF receptor 2 0.0251 0.0989 0.2978
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0138 0.0369 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.0251 0.0989 0.2978
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0251 0.0989 0.2978
Plasmodium vivax 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0085 0.0079 0.5
Echinococcus multilocularis cAMP specific 3',5' cyclic phosphodiesterase 0.0644 0.3137 1
Brugia malayi Probable 3',5'-cyclic phosphodiesterase C32E12.2, putative 0.0104 0.0184 0.0406
Echinococcus granulosus G protein coupled receptor 139 0.0251 0.0989 0.2978
Mycobacterium tuberculosis Isocitrate lyase Icl (isocitrase) (isocitratase) 0.1898 1 0.5
Loa Loa (eye worm) hypothetical protein 0.0251 0.0989 0.3153
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0251 0.0989 0.2978
Schistosoma mansoni biogenic amine (5HT) receptor 0.0251 0.0989 0.2978
Loa Loa (eye worm) hypothetical protein 0.0251 0.0989 0.3153
Echinococcus granulosus microtubule associated protein 2 0.017 0.0543 0.1518
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0138 0.0369 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0251 0.0989 0.2978
Loa Loa (eye worm) hypothetical protein 0.0251 0.0989 0.3153
Plasmodium falciparum 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0085 0.0079 0.5
Schistosoma mansoni adenoreceptor 0.0251 0.0989 0.2978
Echinococcus multilocularis rhodopsin orphan GPCR 0.0251 0.0989 0.2978
Loa Loa (eye worm) hypothetical protein 0.0251 0.0989 0.3153
Giardia lamblia CAMP-specific 3,5-cyclic phosphodiesterase 4B 0.0644 0.3137 1
Plasmodium falciparum phosphodiesterase delta, putative 0.0085 0.0079 0.5
Loa Loa (eye worm) neuropeptide F receptor 0.0251 0.0989 0.3153
Plasmodium falciparum cGMP-specific phosphodiesterase 0.0085 0.0079 0.5
Brugia malayi G-protein coupled receptor 0.0251 0.0989 0.3511
Loa Loa (eye worm) hypothetical protein 0.0251 0.0989 0.3153
Echinococcus multilocularis allatostatin A receptor 0.0251 0.0989 0.2978
Echinococcus multilocularis neuropeptides capa receptor 0.0251 0.0989 0.2978
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0251 0.0989 0.2978
Echinococcus multilocularis rhodopsin orphan GPCR 0.0251 0.0989 0.2978
Onchocerca volvulus 0.0251 0.0989 1
Trichomonas vaginalis cAMP-specific 3,5-cyclic phosphodiesterase, putative 0.0138 0.0369 1
Echinococcus multilocularis microtubule associated protein 2 0.017 0.0543 0.1518
Echinococcus granulosus tm gpcr rhodopsin 0.0251 0.0989 0.2978
Trichomonas vaginalis cone cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0138 0.0369 1
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0085 0.0079 0.1969
Trichomonas vaginalis conserved hypothetical protein 0.0085 0.0079 0.1969
Loa Loa (eye worm) hypothetical protein 0.0251 0.0989 0.3153
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0251 0.0989 0.2978
Mycobacterium tuberculosis Probable isocitrate lyase AceAb [second part] (isocitrase) (isocitratase) (Icl) 0.1898 1 0.5
Brugia malayi putative neuropeptide receptor 0.0251 0.0989 0.3511
Schistosoma mansoni camp/cgmp cyclic nucleotide phosphodiesterase 0.0138 0.0369 0.0948
Brugia malayi Dopamine receptor protein 2 0.0251 0.0989 0.3511
Echinococcus granulosus rhodopsin orphan GPCR 0.0251 0.0989 0.2978
Loa Loa (eye worm) hypothetical protein 0.0251 0.0989 0.3153
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0138 0.0369 1
Brugia malayi hypothetical protein 0.0251 0.0989 0.3511
Echinococcus multilocularis sex peptide receptor 0.0251 0.0989 0.2978
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0138 0.0369 1
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0085 0.0079 0.1969
Brugia malayi hypothetical protein 0.0251 0.0989 0.3511
Schistosoma mansoni myosin xvIII 0.0251 0.0989 0.2978
Echinococcus multilocularis cAMP and cAMP inhibited cGMP 3',5' cyclic 0.0104 0.0184 0.0344
Echinococcus multilocularis neuropeptides capa receptor 0.0251 0.0989 0.2978
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0251 0.0989 0.2978
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0251 0.0989 0.3153
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0138 0.0369 1
Trichomonas vaginalis cAMP and cAMP-inhibited cGMP 3,5-cyclic phosphodiesterase, putative 0.0119 0.0263 0.7083
Echinococcus multilocularis cAMP specific 3',5' cyclic phosphodiesterase 0.0644 0.3137 1
Loa Loa (eye worm) hypothetical protein 0.0251 0.0989 0.3153
Plasmodium vivax cyclic nucleotide phosphodiesterase, putative 0.0085 0.0079 0.5
Echinococcus granulosus rhodopsin orphan GPCR 0.0251 0.0989 0.2978
Echinococcus multilocularis orexin receptor type 2 0.0251 0.0989 0.2978
Brugia malayi hypothetical protein 0.0251 0.0989 0.3511
Brugia malayi larval opioid receptor 0.0251 0.0989 0.3511
Schistosoma mansoni microtubule-associated protein tau 0.017 0.0543 0.1518
Echinococcus granulosus orexin receptor type 2 0.0251 0.0989 0.2978
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0251 0.0989 0.2978
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0104 0.0184 0.4886
Schistosoma mansoni neuropeptide receptor 0.0251 0.0989 0.2978
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.0138 0.0369 1
Onchocerca volvulus 0.0251 0.0989 1
Loa Loa (eye worm) hypothetical protein 0.0251 0.0989 0.3153
Brugia malayi ORL1-like opioid receptor 0.0251 0.0989 0.3511
Loa Loa (eye worm) hypothetical protein 0.0085 0.0079 0.025
Schistosoma mansoni neuropeptide receptor 0.0251 0.0989 0.2978
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0251 0.0989 0.2978
Echinococcus multilocularis G-protein coupled receptor, putative 0.0251 0.0989 0.2978
Schistosoma mansoni amine GPCR 0.0251 0.0989 0.2978
Brugia malayi G-protein coupled receptor 0.0251 0.0989 0.3511
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0251 0.0989 0.2978
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0138 0.0369 1
Onchocerca volvulus 0.0251 0.0989 1
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0138 0.0369 1
Brugia malayi Serotonin receptor 0.0251 0.0989 0.3511
Onchocerca volvulus 0.0251 0.0989 1
Loa Loa (eye worm) hypothetical protein 0.0251 0.0989 0.3153
Brugia malayi GnHR receptor homolog 0.0251 0.0989 0.3511
Loa Loa (eye worm) hypothetical protein 0.0251 0.0989 0.3153
Loa Loa (eye worm) hypothetical protein 0.0251 0.0989 0.3153
Echinococcus granulosus neuropeptide receptor 0.0251 0.0989 0.2978
Loa Loa (eye worm) hypothetical protein 0.0251 0.0989 0.3153
Echinococcus granulosus 7tm_1 domain containing protein 0.0251 0.0989 0.2978
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0251 0.0989 0.3511
Mycobacterium ulcerans isocitrate lyase AceAb 0.1898 1 0.5
Loa Loa (eye worm) hypothetical protein 0.0251 0.0989 0.3153
Echinococcus multilocularis serotonin receptor 0.0251 0.0989 0.2978
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0251 0.0989 0.2978
Schistosoma mansoni biogenic amine receptor 0.0251 0.0989 0.2978
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0251 0.0989 0.3153
Onchocerca volvulus 0.0251 0.0989 1
Loa Loa (eye worm) hypothetical protein 0.0251 0.0989 0.3153
Loa Loa (eye worm) hypothetical protein 0.0251 0.0989 0.3153
Echinococcus multilocularis dro:myosuppressin receptor 0.0251 0.0989 0.2978
Giardia lamblia hypothetical protein 0.0085 0.0079 0.0227
Schistosoma mansoni hypothetical protein 0.0251 0.0989 0.2978
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0251 0.0989 0.2978
Schistosoma mansoni amine GPCR 0.0251 0.0989 0.2978
Loa Loa (eye worm) hypothetical protein 0.0251 0.0989 0.3153
Schistosoma mansoni growth hormone secretagogue receptor 0.0251 0.0989 0.2978
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0138 0.0369 1
Echinococcus granulosus dro:myosuppressin receptor 0.0251 0.0989 0.2978
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0138 0.0369 1
Schistosoma mansoni hypothetical protein 0.0251 0.0989 0.2978
Brugia malayi 3'5'-cyclic nucleotide phosphodiesterase family protein 0.0104 0.0184 0.0406
Loa Loa (eye worm) hypothetical protein 0.0251 0.0989 0.3153
Schistosoma mansoni neuropeptide receptor 0.0251 0.0989 0.2978
Schistosoma mansoni opsin-like receptor 0.0251 0.0989 0.2978
Echinococcus multilocularis neuropeptide receptor 0.0251 0.0989 0.2978
Echinococcus granulosus tachykinin peptides receptor 99D 0.0251 0.0989 0.2978
Echinococcus multilocularis g-protein coupled receptor 0.0251 0.0989 0.2978
Echinococcus multilocularis cAMP specific 3',5' cyclic phosphodiesterase 0.0559 0.2673 0.8481
Loa Loa (eye worm) hypothetical protein 0.0644 0.3137 1
Echinococcus multilocularis neuropeptide Y receptor 0.0251 0.0989 0.2978
Brugia malayi G protein-coupled receptor 0.0251 0.0989 0.3511
Echinococcus granulosus biogenic amine 5HT receptor 0.0251 0.0989 0.2978
Echinococcus granulosus subfamily M14A unassigned peptidase 0.0085 0.008 0.0005
Schistosoma mansoni hypothetical protein 0.0251 0.0989 0.2978
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0251 0.0989 0.2978
Trypanosoma brucei cAMP-specific phosphodiesterase 0.0138 0.0369 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0251 0.0989 0.2978
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0251 0.0989 0.2978
Loa Loa (eye worm) hypothetical protein 0.0251 0.0989 0.3153
Loa Loa (eye worm) hypothetical protein 0.0251 0.0989 0.3153
Brugia malayi Melatonin receptor type 1A 0.0251 0.0989 0.3511
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0251 0.0989 0.2978
Schistosoma mansoni neuropeptide F-like receptor 0.0251 0.0989 0.2978
Echinococcus multilocularis G protein coupled receptor 139 0.0251 0.0989 0.2978
Loa Loa (eye worm) hypothetical protein 0.0251 0.0989 0.3153
Loa Loa (eye worm) hypothetical protein 0.0251 0.0989 0.3153
Brugia malayi RE15519p 0.0251 0.0989 0.3511
Loa Loa (eye worm) hypothetical protein 0.0251 0.0989 0.3153
Onchocerca volvulus 0.0251 0.0989 1
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0251 0.0989 0.2978
Echinococcus granulosus biogenic amine 5HT receptor 0.0251 0.0989 0.2978
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0251 0.0989 0.2978
Echinococcus granulosus tm gpcr rhodopsin 0.0251 0.0989 0.2978
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0072 0.0007 0.5
Echinococcus granulosus tm gpcr rhodopsin 0.0251 0.0989 0.2978
Onchocerca volvulus 0.0251 0.0989 1
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0251 0.0989 0.3511
Echinococcus granulosus peptide allatostatin:somatostatin 0.0251 0.0989 0.2978
Schistosoma mansoni cgmp-dependent 35-cyclic phosphodiesterase 0.0104 0.0184 0.0344
Schistosoma mansoni amine GPCR 0.0251 0.0989 0.2978
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0251 0.0989 0.2978
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0251 0.0989 0.2978
Brugia malayi AKH receptor 0.0251 0.0989 0.3511
Loa Loa (eye worm) PDE1B protein 0.0085 0.0079 0.025
Loa Loa (eye worm) hypothetical protein 0.0251 0.0989 0.3153
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0251 0.0989 0.2978
Brugia malayi follicle stimulating hormone receptor 0.0251 0.0989 0.3511
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0104 0.0184 0.4886
Onchocerca volvulus 0.0251 0.0989 1
Echinococcus multilocularis fmrfamide receptor 0.0251 0.0989 0.2978
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.0138 0.0369 1
Echinococcus granulosus allatostatin A receptor 0.0251 0.0989 0.2978
Echinococcus granulosus rhodopsin orphan GPCR 0.0251 0.0989 0.2978
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0138 0.0369 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0251 0.0989 0.2978
Echinococcus granulosus g protein coupled receptor 0.0251 0.0989 0.2978
Trichomonas vaginalis cGMP-inhibited 3,5-cyclic phosphodiesterase, putative 0.0138 0.0369 1
Schistosoma mansoni histamine h1 receptor 0.0251 0.0989 0.2978
Brugia malayi hypothetical protein 0.0251 0.0989 0.3511
Echinococcus multilocularis g protein coupled receptor 0.0251 0.0989 0.2978
Echinococcus multilocularis rhodopsin orphan GPCR 0.0251 0.0989 0.2978
Schistosoma mansoni amine GPCR 0.0251 0.0989 0.2978
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0251 0.0989 0.2978
Brugia malayi Serotonin receptor 0.0251 0.0989 0.3511
Echinococcus granulosus cAMP and cAMP inhibited cGMP 3'5' cyclic 0.0104 0.0184 0.0344
Echinococcus multilocularis dual 3',5' cyclic AMP and GMP phosphodiesterase 0.0138 0.0369 0.0948
Echinococcus granulosus rhodopsin orphan GPCR 0.0251 0.0989 0.2978
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0251 0.0989 0.2978
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0251 0.0989 0.2978
Loa Loa (eye worm) hypothetical protein 0.0104 0.0184 0.0586
Echinococcus multilocularis neuropeptide FF receptor 2 0.0251 0.0989 0.2978
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0138 0.0369 1
Loa Loa (eye worm) hypothetical protein 0.0251 0.0989 0.3153
Echinococcus multilocularis neuropeptide receptor A26 0.0251 0.0989 0.2978
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0138 0.0369 1
Echinococcus granulosus neuropeptide Y receptor 0.0251 0.0989 0.2978
Trichomonas vaginalis conserved hypothetical protein 0.0138 0.0369 1
Onchocerca volvulus 0.0251 0.0989 1
Loa Loa (eye worm) hypothetical protein 0.0251 0.0989 0.3153
Echinococcus multilocularis rhodopsin orphan GPCR 0.0251 0.0989 0.2978
Loa Loa (eye worm) hypothetical protein 0.0251 0.0989 0.3153
Loa Loa (eye worm) hypothetical protein 0.0251 0.0989 0.3153
Onchocerca volvulus 0.0251 0.0989 1
Trypanosoma brucei cAMP-specific phosphodiesterase 0.0138 0.0369 1
Echinococcus granulosus serotonin receptor 0.0251 0.0989 0.2978
Echinococcus multilocularis g protein coupled receptor 0.0251 0.0989 0.2978
Trichomonas vaginalis conserved hypothetical protein 0.0085 0.0079 0.1969
Loa Loa (eye worm) hypothetical protein 0.0251 0.0989 0.3153
Loa Loa (eye worm) melatonin receptor type 1A 0.0251 0.0989 0.3153
Brugia malayi Dopamine receptor 0.0251 0.0989 0.3511
Loa Loa (eye worm) TYRA-2 protein 0.0251 0.0989 0.3153
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0085 0.0079 0.1969
Echinococcus granulosus cAMP specific 3'5' cyclic phosphodiesterase 0.0644 0.3137 1
Echinococcus granulosus neuropeptide Y receptor 0.0251 0.0989 0.2978
Brugia malayi hypothetical protein 0.0251 0.0989 0.3511
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0251 0.0989 0.2978
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0138 0.0369 1
Echinococcus granulosus neuropeptide receptor 0.0251 0.0989 0.2978
Echinococcus granulosus rhodopsin orphan GPCR 0.0251 0.0989 0.2978
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0251 0.0989 0.2978
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0251 0.0989 0.3153
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.0119 0.0263 0.7083
Echinococcus multilocularis serotonin receptor 0.0251 0.0989 0.2978
Schistosoma mansoni neuropeptide receptor 0.0251 0.0989 0.2978
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0251 0.0989 0.2978
Plasmodium falciparum cGMP-specific phosphodiesterase 0.0085 0.0079 0.5
Schistosoma mansoni alpha-1 adrenergic receptor 0.0251 0.0989 0.2978
Echinococcus granulosus hypothetical protein 0.0251 0.0989 0.2978
Echinococcus multilocularis g protein coupled receptor 0.0251 0.0989 0.2978
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0251 0.0989 0.3153
Onchocerca volvulus 0.0251 0.0989 1
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0251 0.0989 0.2978
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0119 0.0263 0.6368
Plasmodium vivax phosphodiesterase gamma, putative 0.0085 0.0079 0.5
Onchocerca volvulus Neuropeptide F receptor homolog 0.0251 0.0989 1
Trichomonas vaginalis cAMP/cGMP cyclic nucleotide phosphodiesterase, putative 0.0138 0.0369 1
Echinococcus granulosus cAMP specific 3'5' cyclic phosphodiesterase 0.0644 0.3137 1
Giardia lamblia Hypothetical protein 0.0085 0.0079 0.0227
Schistosoma mansoni biogenic amine receptor 0.0251 0.0989 0.2978
Brugia malayi hypothetical protein 0.0251 0.0989 0.3511
Schistosoma mansoni biogenic amine receptor 0.0251 0.0989 0.2978
Plasmodium falciparum 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0085 0.0079 0.5
Loa Loa (eye worm) hypothetical protein 0.0251 0.0989 0.3153
Mycobacterium ulcerans isocitrate lyase Icl 0.1898 1 0.5
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0251 0.0989 0.3511
Schistosoma mansoni neuropeptide F-like receptor 0.0251 0.0989 0.2978
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0251 0.0989 0.2978
Schistosoma mansoni hypothetical protein 0.0251 0.0989 0.2978
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0085 0.0079 0.1969
Loa Loa (eye worm) hypothetical protein 0.0251 0.0989 0.3153
Echinococcus granulosus somatostatin receptor 0.0251 0.0989 0.2978
Echinococcus granulosus neuropeptides capa receptor 0.0251 0.0989 0.2978
Echinococcus granulosus g-protein coupled receptor 0.0251 0.0989 0.2978
Schistosoma mansoni subfamily M14A unassigned peptidase (M14 family) 0.0085 0.008 0.0005
Loa Loa (eye worm) hypothetical protein 0.0251 0.0989 0.3153
Echinococcus granulosus dual 3'5' cyclic AMP and GMP phosphodiesterase 0.0138 0.0369 0.0948
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0138 0.0369 1
Echinococcus granulosus 7TM GPCR rhodopsin 0.0251 0.0989 0.2978
Echinococcus granulosus g protein coupled receptor 0.0251 0.0989 0.2978
Trichomonas vaginalis cAMP and cAMP-inhibited cGMP 3,5-cyclic phosphodiesterase, putative 0.0085 0.0079 0.1969
Schistosoma mansoni opsin-like receptor 0.0251 0.0989 0.2978
Trichomonas vaginalis cGMP-inhibited 3,5-cyclic phosphodiesterase, putative 0.0085 0.0079 0.1969
Loa Loa (eye worm) calcium/calmodulin-stimulated cyclic nucleotide phosphodiesterase 0.0085 0.0079 0.025
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0138 0.0369 1
Loa Loa (eye worm) hypothetical protein 0.0251 0.0989 0.3153
Onchocerca volvulus 0.0251 0.0989 1
Onchocerca volvulus 0.0251 0.0989 1
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0138 0.0369 1
Loa Loa (eye worm) G-protein coupled receptor 0.0251 0.0989 0.3153
Schistosoma mansoni biogenic amine (5HT) receptor 0.0251 0.0989 0.2978
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0251 0.0989 0.2978
Echinococcus multilocularis rhodopsin orphan GPCR 0.0251 0.0989 0.2978
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0251 0.0989 0.2978
Loa Loa (eye worm) hypothetical protein 0.0251 0.0989 0.3153
Brugia malayi hypothetical protein 0.0251 0.0989 0.3511
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0085 0.0079 0.1969
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0251 0.0989 0.2978
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0138 0.0369 1
Loa Loa (eye worm) hypothetical protein 0.0251 0.0989 0.3153
Onchocerca volvulus 0.0251 0.0989 1
Echinococcus granulosus g protein coupled receptor 0.0251 0.0989 0.2978
Trichomonas vaginalis calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0085 0.0079 0.1969
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0251 0.0989 0.2978
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0072 0.0007 0.5
Echinococcus granulosus rhodopsin orphan GPCR 0.0251 0.0989 0.2978
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0138 0.0369 1
Loa Loa (eye worm) hypothetical protein 0.0251 0.0989 0.3153
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0138 0.0369 1
Plasmodium vivax 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0085 0.0079 0.5
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0251 0.0989 0.2978
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0644 0.3137 1
Mycobacterium tuberculosis Probable isocitrate lyase AceAa [first part] (isocitrase) (isocitratase) (Icl) 0.1898 1 0.5
Brugia malayi hypothetical protein 0.0251 0.0989 0.3511
Loa Loa (eye worm) neuropeptide F receptor 0.0251 0.0989 0.3153
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.0644 0.3137 1
Loa Loa (eye worm) hypothetical protein 0.0085 0.0079 0.025
Echinococcus multilocularis neuropeptide Y receptor 0.0251 0.0989 0.2978
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0085 0.0079 0.1969
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0251 0.0989 0.2978
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0251 0.0989 0.2978
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0251 0.0989 0.2978
Echinococcus granulosus sex peptide receptor 0.0251 0.0989 0.2978
Schistosoma mansoni opsin-like receptor 0.0251 0.0989 0.2978
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0251 0.0989 0.3511
Loa Loa (eye worm) hypothetical protein 0.0251 0.0989 0.3153
Treponema pallidum fructose-bisphosphate aldolase 0.0072 0.0007 0.5
Plasmodium falciparum phosphodiesterase gamma, putative 0.0085 0.0079 0.5
Brugia malayi neuropeptide F receptor 0.0251 0.0989 0.3511
Brugia malayi neuropeptide F receptor 0.0251 0.0989 0.3511
Echinococcus multilocularis rhodopsin orphan GPCR 0.0251 0.0989 0.2978
Brugia malayi G protein-coupled receptor F59B2.13 0.0251 0.0989 0.3511
Loa Loa (eye worm) hypothetical protein 0.0251 0.0989 0.3153
Trichomonas vaginalis cAMP-specific 3,5-cyclic phosphodiesterase, putative 0.0138 0.0369 1
Brugia malayi Dopamine receptor protein 1 0.0251 0.0989 0.3511
Echinococcus multilocularis rhodopsin orphan GPCR 0.0251 0.0989 0.2978
Loa Loa (eye worm) hypothetical protein 0.0251 0.0989 0.3153
Loa Loa (eye worm) hypothetical protein 0.0251 0.0989 0.3153
Brugia malayi hypothetical protein 0.0251 0.0989 0.3511
Echinococcus granulosus alpha 1A adrenergic receptor 0.0251 0.0989 0.2978
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0251 0.0989 0.2978
Loa Loa (eye worm) hypothetical protein 0.0251 0.0989 0.3153
Echinococcus multilocularis neuropeptide receptor 0.0251 0.0989 0.2978
Echinococcus multilocularis neuropeptide s receptor 0.0251 0.0989 0.2978
Loa Loa (eye worm) hypothetical protein 0.0251 0.0989 0.3153
Brugia malayi hypothetical protein 0.0251 0.0989 0.3511
Brugia malayi Tachykinin-like peptides receptor 99D 0.0251 0.0989 0.3511
Loa Loa (eye worm) G-protein coupled receptor 0.0251 0.0989 0.3153
Loa Loa (eye worm) hypothetical protein 0.0251 0.0989 0.3153
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0138 0.0369 1
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0138 0.0369 1
Schistosoma mansoni amine GPCR 0.0251 0.0989 0.2978
Brugia malayi putative neuropeptide receptor NPR1 0.0251 0.0989 0.3511
Brugia malayi Probable 3',5'-cyclic phosphodiesterase R153.1, putative 0.0559 0.2673 1
Echinococcus granulosus neuropeptide s receptor 0.0251 0.0989 0.2978
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0251 0.0989 0.3153

Activities

Activity type Activity value Assay description Source Reference
Activity (binding) Inhibition of human plasma kallikrein at 55 uM ChEMBL. 17850059
Activity (binding) Inhibition of human spleen cathepsin D at 55 uM ChEMBL. 17850059
Activity (binding) Inhibition of pig kidney aminopeptidase M at 55 uM ChEMBL. 17850059
Activity (binding) Inhibition of human urokinase at 55 uM ChEMBL. 17850059
Activity (binding) Inhibition of human thrombin at 55 uM ChEMBL. 17850059
Activity (binding) 0 Inhibition of pig kidney aminopeptidase M at 55 uM ChEMBL. 17850059
Activity (binding) 0 Inhibition of human spleen cathepsin D at 55 uM ChEMBL. 17850059
Activity (binding) 0 Inhibition of human plasma kallikrein at 55 uM ChEMBL. 17850059
Activity (binding) 0 Inhibition of human thrombin at 55 uM ChEMBL. 17850059
Activity (binding) 0 Inhibition of human pancreatic chymotrypsin at 55 uM ChEMBL. 17850059
Activity (binding) 0 Inhibition of human urokinase at 55 uM ChEMBL. 17850059
Ki (binding) = 29900 nM Inhibition of human NE ChEMBL. 17850059
Ki (binding) = 29900 nM Inhibition of human NE ChEMBL. 17850059

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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