Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0484 | 0.5 | 0.5 |
Plasmodium falciparum | cysteine repeat modular protein 1 | 0.0484 | 0.5 | 0.5 |
Echinococcus granulosus | tissue type plasminogen activator | 0.0484 | 0.5 | 0.5 |
Onchocerca volvulus | 0.0484 | 0.5 | 0.5 | |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0484 | 0.5 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0484 | 0.5 | 0.5 |
Toxoplasma gondii | kringle domain-containing protein | 0.0484 | 0.5 | 0.5 |
Brugia malayi | Kringle domain containing protein | 0.0484 | 0.5 | 0.5 |
Plasmodium vivax | cysteine repeat modular protein 1, putative | 0.0484 | 0.5 | 0.5 |
Leishmania major | hypothetical protein, conserved | 0.0484 | 0.5 | 0.5 |
Echinococcus multilocularis | tissue type plasminogen activator | 0.0484 | 0.5 | 0.5 |
Loa Loa (eye worm) | TK/ROR protein kinase | 0.0484 | 0.5 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | = 0.58 uM | Cytotoxicity against mouse EAC cells after 24 hrs by MTT assay | ChEMBL. | 17400463 |
IC50 (functional) | = 0.58 uM | Cytotoxicity against mouse Ehrlich ascites carcinoma cells after 24 hrs by MTT assay | ChEMBL. | 18281125 |
IC50 (functional) | = 1.07 uM | Cytotoxicity against human A375 cells after 24 hrs by MTT assay | ChEMBL. | 17400463 |
IC50 (functional) | = 1.07 uM | Cytotoxicity against human A375 cells after 24 hrs by MTT assay | ChEMBL. | 17400463 |
IC50 (functional) | = 1.07 uM | Cytotoxicity against human A375 cells after 24 hrs by MTT assay | ChEMBL. | 18281125 |
IC50 (functional) | = 1.1 uM | Cytotoxicity against human A375 cells | ChEMBL. | 20615584 |
IC50 (functional) | = 2.39 uM | Cytotoxicity against human Hep2 cells after 24 hrs by MTT assay | ChEMBL. | 17400463 |
IC50 (functional) | = 2.39 uM | Cytotoxicity against human Hep2 cells after 24 hrs by MTT assay | ChEMBL. | 17400463 |
IC50 (functional) | = 2.39 uM | Cytotoxicity against human Hep2 cells after 24 hrs by MTT assay | ChEMBL. | 18281125 |
IC50 (functional) | = 2.4 uM | Cytotoxicity against human Hep2 cells | ChEMBL. | 20615584 |
IC50 (functional) | = 15.9 uM | Cytotoxicity against human A431 cells by MTT assay | ChEMBL. | 18281125 |
IC50 (functional) | = 18.95 uM | Cytotoxicity against human MCF7 cells by MTT assay | ChEMBL. | 18281125 |
IC50 (functional) | = 30 uM | Cytotoxicity against human HL60 cells | ChEMBL. | 20615584 |
IC50 (functional) | = 30.07 uM | Cytotoxicity against human HL60 cells by MTT assay | ChEMBL. | 18281125 |
IC50 (functional) | = 40 uM | Cytotoxicity against human K562 cells | ChEMBL. | 20615584 |
IC50 (functional) | = 40.16 uM | Cytotoxicity against human K562 cells by MTT assay | ChEMBL. | 18281125 |
IC50 (ADMET) | = 55.49 uM | Cytotoxicity against human PBMCs after 24 hrs by MTT assay | ChEMBL. | 17400463 |
IC50 (ADMET) | = 55.49 uM | Cytotoxicity against human PBMCs after 24 hrs by MTT assay | ChEMBL. | 17400463 |
IC50 (ADMET) | = 55.49 uM | Cytotoxicity against human PBMC cells after 24 hrs by MTT assay | ChEMBL. | 18281125 |
IC50 (ADMET) | = 55.5 uM | Cytotoxicity against human PBMC | ChEMBL. | 20615584 |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Mus musculus | ChEMBL23 | 18281125 | |
Homo sapiens | ChEMBL23 | 17400463 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.