Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Onchocerca volvulus | 0.0248 | 0.3975 | 1 | |
Echinococcus granulosus | arachidonate 5 lipoxygenase | 0.0454 | 0.9728 | 1 |
Echinococcus granulosus | tissue type plasminogen activator | 0.0248 | 0.3975 | 0.4086 |
Echinococcus granulosus | peroxidasin | 0.0129 | 0.0633 | 0.065 |
Leishmania major | hypothetical protein, conserved | 0.0248 | 0.3975 | 0.5 |
Echinococcus multilocularis | arachidonate 5 lipoxygenase | 0.0454 | 0.9728 | 1 |
Schistosoma mansoni | lipoxygenase | 0.0454 | 0.9728 | 0.9728 |
Schistosoma mansoni | peroxidasin | 0.0129 | 0.0633 | 0.0633 |
Schistosoma mansoni | lipoxygenase | 0.0317 | 0.5906 | 0.5906 |
Plasmodium vivax | cysteine repeat modular protein 1, putative | 0.0248 | 0.3975 | 0.5 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0248 | 0.3975 | 0.5 |
Loa Loa (eye worm) | TK/ROR protein kinase | 0.0248 | 0.3975 | 1 |
Brugia malayi | Kringle domain containing protein | 0.0248 | 0.3975 | 1 |
Echinococcus multilocularis | tissue type plasminogen activator | 0.0248 | 0.3975 | 0.4086 |
Schistosoma mansoni | peroxidasin | 0.0129 | 0.0633 | 0.0633 |
Schistosoma mansoni | hypothetical protein | 0.0248 | 0.3975 | 0.3975 |
Toxoplasma gondii | kringle domain-containing protein | 0.0248 | 0.3975 | 1 |
Plasmodium falciparum | cysteine repeat modular protein 1 | 0.0248 | 0.3975 | 0.5 |
Echinococcus multilocularis | peroxidasin | 0.0129 | 0.0633 | 0.065 |
Loa Loa (eye worm) | hypothetical protein | 0.0248 | 0.3975 | 1 |
Schistosoma mansoni | nuclear hormone receptor superfamily protein-related | 0.0357 | 0.7026 | 0.7026 |
Brugia malayi | Protein kinase domain containing protein | 0.0248 | 0.3975 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (functional) | 0 | Inhibition of IL1beta-induced MMP13 production in human SW1353 cells at 50 uM | ChEMBL. | 17267227 |
Activity (functional) | 0 | Reduction of IL1beta plus AMPA-induced proteoglycan degradation in rabbit articular cartilage at 200 uM relative to control | ChEMBL. | 17267227 |
IC50 (binding) | = 110 uM | Inhibition of human MMP8 | ChEMBL. | 17267227 |
IC50 (binding) | = 110 uM | Inhibition of human MMP8 | ChEMBL. | 17267227 |
IC50 (binding) | = 120 uM | Inhibition of human MMP13 | ChEMBL. | 17267227 |
IC50 (binding) | = 120 uM | Inhibition of human MMP13 | ChEMBL. | 17267227 |
IC50 (binding) | = 140 uM | Inhibition of human MMP2 | ChEMBL. | 17267227 |
IC50 (binding) | = 140 uM | Inhibition of human MMP2 | ChEMBL. | 17267227 |
IC50 (binding) | = 150 uM | Inhibition of human MMP3 | ChEMBL. | 17267227 |
IC50 (binding) | = 150 uM | Inhibition of human MMP3 | ChEMBL. | 17267227 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.