Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | checkpoint kinase 1 | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Loa Loa (eye worm) | CAMK/CAMKL/CHK1 protein kinase | Get druggable targets OG5_130454 | All targets in OG5_130454 |
Brugia malayi | Protein kinase domain containing protein | Get druggable targets OG5_130454 | All targets in OG5_130454 |
Schistosoma japonicum | Serine/threonine-protein kinase Chk1, putative | Get druggable targets OG5_130454 | All targets in OG5_130454 |
Schistosoma mansoni | serine/threonine protein kinase | Get druggable targets OG5_130454 | All targets in OG5_130454 |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0593 | 1 | 1 |
Schistosoma mansoni | nuclear hormone receptor | 0.0593 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0313 | 0.1071 | 0.1071 |
Loa Loa (eye worm) | hypothetical protein | 0.0313 | 0.1071 | 0.1071 |
Schistosoma mansoni | photoreceptor-specific nuclear receptor related | 0.0593 | 1 | 1 |
Echinococcus granulosus | ecdysone induced protein 78C | 0.0593 | 1 | 1 |
Brugia malayi | nuclear receptor NHR-88 | 0.0593 | 1 | 1 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.0313 | 0.1071 | 0.1071 |
Onchocerca volvulus | 0.0593 | 1 | 1 | |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0593 | 1 | 1 |
Echinococcus granulosus | COUP TF:Svp nuclear hormone receptor | 0.0593 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0313 | 0.1071 | 0.1071 |
Echinococcus granulosus | nuclear receptor subfamily 1 group D | 0.0313 | 0.1071 | 0.1071 |
Schistosoma mansoni | Tr4/Tr2 (homologue) | 0.0593 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-3 | 0.0593 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0593 | 1 | 1 |
Onchocerca volvulus | Protein ultraspiracle homolog | 0.0593 | 1 | 1 |
Onchocerca volvulus | Bile acid receptor homolog | 0.0593 | 1 | 1 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-40 | 0.0593 | 1 | 1 |
Brugia malayi | nuclear hormone receptor | 0.0593 | 1 | 1 |
Schistosoma mansoni | retinoic acid receptor RXR | 0.0593 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0593 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0313 | 0.1071 | 0.1071 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0593 | 1 | 1 |
Echinococcus granulosus | Nuclear hormone receptor family member nhr 41 | 0.0593 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-1 | 0.0593 | 1 | 1 |
Echinococcus multilocularis | nuclear receptor subfamily 1 group D | 0.0313 | 0.1071 | 0.1071 |
Brugia malayi | Nuclear hormone receptor family member nhr-31 | 0.0593 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0593 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-40 | 0.0593 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-14 | 0.0593 | 1 | 1 |
Echinococcus granulosus | FTZ F1 alpha | 0.0593 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0593 | 1 | 1 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.0593 | 1 | 1 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-31 | 0.0593 | 1 | 1 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0593 | 1 | 1 |
Echinococcus multilocularis | Nuclear hormone receptor family member nhr 41 | 0.0593 | 1 | 1 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-14 | 0.0593 | 1 | 1 |
Echinococcus multilocularis | COUP TF:Svp nuclear hormone receptor | 0.0593 | 1 | 1 |
Echinococcus granulosus | FTZ F1 nuclear receptor protein | 0.0593 | 1 | 1 |
Schistosoma mansoni | nuclear hormone receptor nor-1/nor-2 | 0.0593 | 1 | 1 |
Schistosoma mansoni | thyroid hormone receptor | 0.0593 | 1 | 1 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-41 | 0.0593 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-41 | 0.0593 | 1 | 1 |
Brugia malayi | hypothetical protein | 0.0313 | 0.1071 | 0.1071 |
Loa Loa (eye worm) | hypothetical protein | 0.0593 | 1 | 1 |
Brugia malayi | hypothetical protein | 0.0313 | 0.1071 | 0.1071 |
Onchocerca volvulus | Steroid hormone receptor family member cnr14 homolog | 0.0593 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0313 | 0.1071 | 0.1071 |
Loa Loa (eye worm) | hypothetical protein | 0.0313 | 0.1071 | 0.1071 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-1 | 0.0593 | 1 | 1 |
Echinococcus multilocularis | FTZ F1 alpha | 0.0593 | 1 | 1 |
Schistosoma mansoni | RAR-like nuclear receptor | 0.0593 | 1 | 1 |
Loa Loa (eye worm) | nuclear Hormone Receptor family member | 0.0593 | 1 | 1 |
Echinococcus multilocularis | hepatocyte nuclear factor 4 alpha | 0.0593 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-49 | 0.0593 | 1 | 1 |
Echinococcus granulosus | hepatocyte nuclear factor 4 alpha | 0.0593 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0313 | 0.1071 | 0.1071 |
Echinococcus multilocularis | ecdysone induced protein 78C | 0.0593 | 1 | 1 |
Brugia malayi | nuclear receptor RXR | 0.0313 | 0.1071 | 0.1071 |
Schistosoma mansoni | steroid hormone receptor ad4bp | 0.0593 | 1 | 1 |
Schistosoma mansoni | nuclear receptor 2DBD-gamma | 0.0593 | 1 | 1 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0593 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0593 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0593 | 1 | 1 |
Schistosoma mansoni | FTZ-F1 nuclear receptor-like protein | 0.0593 | 1 | 1 |
Loa Loa (eye worm) | nuclear hormone receptor-like 1 | 0.0313 | 0.1071 | 0.1071 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0593 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0593 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0593 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0593 | 1 | 1 |
Schistosoma mansoni | thyroid hormone receptor | 0.0593 | 1 | 1 |
Schistosoma mansoni | coup transcription factor | 0.0593 | 1 | 1 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-49 | 0.0593 | 1 | 1 |
Echinococcus granulosus | retinoic acid receptor rxr beta a | 0.0593 | 1 | 1 |
Schistosoma mansoni | ecdysone-induced protein 78c (dr-78) | 0.0313 | 0.1071 | 0.1071 |
Echinococcus multilocularis | FTZ F1 nuclear receptor protein | 0.0593 | 1 | 1 |
Loa Loa (eye worm) | steroid hormone receptor | 0.0593 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0593 | 1 | 1 |
Brugia malayi | Steroid receptor seven-up type 2 | 0.0593 | 1 | 1 |
Echinococcus multilocularis | thyroid hormone receptor alpha | 0.0593 | 1 | 1 |
Brugia malayi | photoreceptor-specific nuclear receptor | 0.0593 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0593 | 1 | 1 |
Brugia malayi | steroid hormone receptor | 0.0593 | 1 | 1 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0593 | 1 | 1 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.