Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (functional) | 0 | Induction of apoptosis in human endothelial cells by annexin V apoptosis assay | ChEMBL. | 17467996 |
Activity (functional) | 0 | Induction of apoptosis in human H460 cells by annexin V apoptosis assay | ChEMBL. | 17467996 |
Activity (functional) | 0 | Induction of apoptosis in human LCC6 cells by annexin V apoptosis assay | ChEMBL. | 17467996 |
IC50 (functional) | = 706 nM | Cytotoxicity against human H460 cells after 48 hrs by MTT assay | ChEMBL. | 17467996 |
IC50 (functional) | = 706 nM | Cytotoxicity against human H460 cells after 48 hrs by MTT assay | ChEMBL. | 17467996 |
IC50 (functional) | = 1180 nM | Cytotoxicity against human LCC6 cells after 48 hrs by MTT assay | ChEMBL. | 17467996 |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Homo sapiens | ChEMBL23 | 17467996 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.