Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | Protein-tyrosine phosphatase containing protein | 0.1069 | 0.4316 | 0.4269 |
Loa Loa (eye worm) | protein-tyrosine phosphatase | 0.1069 | 0.4316 | 0.4316 |
Echinococcus granulosus | tyrosine protein phosphatase non receptor type | 0.1069 | 0.4316 | 0.5 |
Echinococcus multilocularis | tyrosine protein phosphatase non receptor type | 0.1069 | 0.4316 | 0.5 |
Onchocerca volvulus | 0.2208 | 1 | 0.5 | |
Schistosoma mansoni | protein tyrosine phosphatase non-receptor type nt1 | 0.1069 | 0.4316 | 0.5 |
Onchocerca volvulus | 0.2208 | 1 | 0.5 | |
Loa Loa (eye worm) | protein-tyrosine phosphatase | 0.2208 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0221 | 0.0082 | 0.0082 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | = 1.04 uM | Cytotoxicity against RPMI 8226/s cells | ChEMBL. | 17442577 |
IC50 (functional) | = 1.07 uM | Cytotoxicity against U937 GTB cells | ChEMBL. | 17442577 |
IC50 (functional) | = 1.07 uM | Cytotoxicity against U937 GTB cells | ChEMBL. | 17442577 |
IC50 (functional) | = 2.24 uM | Cytotoxicity against CEM/s cells | ChEMBL. | 17442577 |
IC50 (functional) | = 3.4 uM | Cytotoxicity against ACHN cells | ChEMBL. | 17442577 |
IC50 (functional) | = 3.4 uM | Cytotoxicity against ACHN cells | ChEMBL. | 17442577 |
Inhibition (functional) | = 99 % | Antimicrobial activity against Mycobacterium tuberculosis at 6.25 ug/mL after 20 hrs by broth microdilution method | ChEMBL. | 17442577 |
Inhibition (functional) | = 99 % | Antimicrobial activity against Mycobacterium tuberculosis at 6.25 ug/mL after 20 hrs by broth microdilution method | ChEMBL. | 17442577 |
MIC (functional) | 0 | Antibacterial activity against Bacteroides fragilis after 20 hrs by broth microdilution method | ChEMBL. | 17442577 |
MIC (functional) | 0 | Antibacterial activity against Bacteroides thetaiotaomicron after 20 hrs by broth microdilution method | ChEMBL. | 17442577 |
MIC (functional) | = 1.56 ug ml-1 | Antimicrobial activity against Mycobacterium tuberculosis after 20 hrs by broth microdilution method | ChEMBL. | 17442577 |
MIC (functional) | = 1.56 ug ml-1 | Antimicrobial activity against Mycobacterium tuberculosis after 20 hrs by broth microdilution method | ChEMBL. | 17442577 |
MIC (functional) | > 32 ug ml-1 | Antibacterial activity against Staphylococcus aureus ATCC 25923 after 20 hrs by broth microdilution method | ChEMBL. | 17442577 |
MIC (functional) | > 32 ug ml-1 | Antibacterial activity against Escherichia coli ATCC 25922 after 20 hrs by broth microdilution method | ChEMBL. | 17442577 |
MIC (functional) | > 32 ug ml-1 | Antibacterial activity against Escherichia coli ATCC 25922 after 20 hrs by broth microdilution method | ChEMBL. | 17442577 |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Homo sapiens | ChEMBL23 | 17442577 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.