Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | opiate receptor-like 1 | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Echinococcus multilocularis | growth hormone secretagogue receptor type 1 | opiate receptor-like 1 | 370 aa | 349 aa | 22.1 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | macrophage migration inhibitory factor 2 | 0.0307 | 0.4044 | 0.4044 |
Loa Loa (eye worm) | macrophage migration inhibitory factor | 0.072 | 1 | 1 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0062 | 0.0511 | 0.0511 |
Loa Loa (eye worm) | macrophage migration inhibitory factor 2 | 0.0307 | 0.4044 | 0.4044 |
Leishmania major | macrophage migration inhibitory factor-like protein | 0.072 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0043 | 0.0227 | 0.0227 |
Leishmania major | macrophage migration inhibitory factor-like protein | 0.072 | 1 | 0.5 |
Echinococcus granulosus | geminin | 0.0112 | 0.1232 | 1 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0043 | 0.0227 | 0.0227 |
Entamoeba histolytica | macrophage migration inhibitory factor-like protein | 0.072 | 1 | 0.5 |
Trichomonas vaginalis | conserved hypothetical protein | 0.072 | 1 | 0.5 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0062 | 0.0511 | 0.0511 |
Schistosoma mansoni | hypothetical protein | 0.0112 | 0.1232 | 1 |
Plasmodium vivax | macrophage migration inhibitory factor, putative | 0.072 | 1 | 0.5 |
Toxoplasma gondii | macrophage migration inhibitory factor, putative | 0.072 | 1 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0112 | 0.1232 | 1 |
Giardia lamblia | Macrophage migration inhibitory factor | 0.072 | 1 | 0.5 |
Trichomonas vaginalis | macrophage migration inhibitory factor, mif, putative | 0.072 | 1 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0043 | 0.0227 | 0.1842 |
Echinococcus multilocularis | geminin | 0.0112 | 0.1232 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0062 | 0.0511 | 0.0511 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0062 | 0.0511 | 0.0511 |
Plasmodium falciparum | macrophage migration inhibitory factor | 0.072 | 1 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Ki (binding) | Displacement of [3H]diprenorphine from human MOP receptor expressed in CHO cell membrane | ChEMBL. | 17420123 | |
Ki (binding) | Displacement of [3H]diprenorphine from human KOP receptor expressed in CHO cell membrane | ChEMBL. | 17420123 | |
Ki (binding) | Displacement of [3H]diprenorphine from human DOP receptor expressed in CHO cell membrane | ChEMBL. | 17420123 | |
Ki (binding) | 0 | Displacement of [3H]diprenorphine from human DOP receptor expressed in CHO cell membrane | ChEMBL. | 17420123 |
Ki (binding) | 0 | Displacement of [3H]diprenorphine from human KOP receptor expressed in CHO cell membrane | ChEMBL. | 17420123 |
Ki (binding) | 0 | Displacement of [3H]diprenorphine from human MOP receptor expressed in CHO cell membrane | ChEMBL. | 17420123 |
Ki (binding) | = 4544 nM | Displacement of [125I][Tyr14]nociceptin FQ from human NOP receptor expressed in CHO cell membrane | ChEMBL. | 17420123 |
Ki (binding) | = 4544 nM | Displacement of [125I][Tyr14]nociceptin FQ from human NOP receptor expressed in CHO cell membrane | ChEMBL. | 17420123 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.