Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | voltage-gated potassium channel | 0.0053 | 0.1877 | 0.1553 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0094 | 0.9027 | 0.9639 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0096 | 0.9351 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0096 | 0.9351 | 0.9325 |
Echinococcus granulosus | potassium voltage gated channel protein | 0.0096 | 0.9351 | 1 |
Echinococcus multilocularis | potassium voltage gated channel protein | 0.0053 | 0.1877 | 0.2007 |
Echinococcus granulosus | sodium channel protein | 0.0044 | 0.0441 | 0.0472 |
Echinococcus granulosus | shaker cognate | 0.0053 | 0.1877 | 0.2007 |
Echinococcus granulosus | voltage gated sodium channel Nav1 alpha subunit | 0.0044 | 0.0441 | 0.0472 |
Brugia malayi | Voltage-gated potassium channel, Shaker-family (KCNA, Kv1-like) alpha-subunit | 0.0096 | 0.9351 | 0.9325 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0053 | 0.1877 | 0.1665 |
Loa Loa (eye worm) | hypothetical protein | 0.01 | 1 | 1 |
Echinococcus multilocularis | potassium voltage gated channel subfamily A | 0.0087 | 0.7858 | 0.8403 |
Leishmania major | calcium channel protein, putative,ion transporter, putative | 0.0044 | 0.0441 | 0.5 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0084 | 0.7328 | 0.7743 |
Echinococcus multilocularis | shaker cognate | 0.0053 | 0.1877 | 0.2007 |
Echinococcus granulosus | potassium voltage gated channel subfamily A | 0.0096 | 0.9351 | 1 |
Echinococcus granulosus | potassium voltage gated channel protein | 0.0053 | 0.1877 | 0.2007 |
Brugia malayi | Voltage-gated potassium channel, Shal-family (KCND, Kv4-like) alpha-subunit. C. elegans shl-1 ortholog | 0.0084 | 0.7328 | 0.7221 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0096 | 0.9351 | 1 |
Brugia malayi | Voltage-gated potassium channel, Shab-family (KCNB, Kv2-like) alpha-subunit. C. elegans exp-2 ortholog | 0.0053 | 0.1877 | 0.1553 |
Echinococcus granulosus | potassium voltage gated channel protein | 0.0094 | 0.9027 | 0.9654 |
Echinococcus multilocularis | potassium voltage gated channel protein | 0.0094 | 0.9027 | 0.9654 |
Echinococcus multilocularis | potassium voltage gated channel protein | 0.0096 | 0.9351 | 1 |
Echinococcus multilocularis | sodium channel protein | 0.0044 | 0.0441 | 0.0472 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Ki (binding) | = 21.1 uM | Inhibition of chorismate mutase in Mycobacterium tuberculosis H37Rv strain | ChEMBL. | 17418569 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.