Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | phosphorylase, glycogen, liver | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | potassium voltage gated channel protein | 0.0107 | 0.7213 | 0.7213 |
Onchocerca volvulus | Glycogen phosphorylase homolog | 0.013 | 1 | 0.5 |
Echinococcus granulosus | sodium channel protein | 0.0049 | 0.034 | 0.034 |
Echinococcus multilocularis | potassium voltage gated channel protein | 0.0105 | 0.6963 | 0.6963 |
Echinococcus granulosus | Glycosyl transferase family 35 | 0.013 | 1 | 1 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0094 | 0.5652 | 0.5519 |
Echinococcus multilocularis | potassium voltage gated channel protein | 0.0059 | 0.1448 | 0.1448 |
Entamoeba histolytica | glycogen phosphorylase, putative | 0.013 | 1 | 1 |
Trichomonas vaginalis | glycogen phosphorylase, putative | 0.013 | 1 | 0.5 |
Leishmania major | calcium channel protein, putative,ion transporter, putative | 0.0049 | 0.034 | 0.5 |
Echinococcus multilocularis | shaker cognate | 0.0059 | 0.1448 | 0.1448 |
Giardia lamblia | Glycogen phosphorylase | 0.013 | 1 | 0.5 |
Echinococcus granulosus | potassium voltage gated channel subfamily A | 0.0107 | 0.7213 | 0.7213 |
Echinococcus multilocularis | Glycosyl transferase, family 35 | 0.013 | 1 | 1 |
Loa Loa (eye worm) | voltage-gated potassium channel | 0.0059 | 0.1448 | 0.1187 |
Echinococcus multilocularis | glycogen phosphorylase | 0.013 | 1 | 1 |
Mycobacterium ulcerans | glycogen phosphorylase GlgP | 0.0056 | 0.117 | 0.5 |
Echinococcus granulosus | potassium voltage gated channel protein | 0.0059 | 0.1448 | 0.1448 |
Echinococcus multilocularis | glycogen phosphorylase | 0.013 | 1 | 1 |
Mycobacterium tuberculosis | Probable glycogen phosphorylase GlgP | 0.0056 | 0.117 | 0.5 |
Echinococcus granulosus | potassium voltage gated channel protein | 0.0107 | 0.7213 | 0.7213 |
Trichomonas vaginalis | glycogen phosphorylase, putative | 0.013 | 1 | 0.5 |
Brugia malayi | Voltage-gated potassium channel, Shal-family (KCND, Kv4-like) alpha-subunit. C. elegans shl-1 ortholog | 0.0094 | 0.5652 | 0.5519 |
Brugia malayi | Voltage-gated potassium channel, Shab-family (KCNB, Kv2-like) alpha-subunit. C. elegans exp-2 ortholog | 0.0059 | 0.1448 | 0.1187 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0059 | 0.1448 | 0.1187 |
Echinococcus multilocularis | potassium voltage gated channel subfamily A | 0.0097 | 0.6061 | 0.6061 |
Brugia malayi | Voltage-gated potassium channel, Shaker-family (KCNA, Kv1-like) alpha-subunit | 0.0107 | 0.7213 | 0.7128 |
Loa Loa (eye worm) | hypothetical protein | 0.0111 | 0.7713 | 0.7644 |
Schistosoma mansoni | glycogen phosphorylase | 0.013 | 1 | 1 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0107 | 0.7213 | 0.7128 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0105 | 0.6963 | 0.687 |
Loa Loa (eye worm) | hypothetical protein | 0.0107 | 0.7213 | 0.7128 |
Echinococcus granulosus | potassium voltage gated channel protein | 0.0105 | 0.6963 | 0.6963 |
Echinococcus granulosus | voltage gated sodium channel Nav1 alpha subunit | 0.0049 | 0.034 | 0.034 |
Entamoeba histolytica | glycogen phosphorylase, putative | 0.013 | 1 | 1 |
Schistosoma mansoni | glycogen phosphorylase | 0.013 | 1 | 1 |
Schistosoma mansoni | glycogen phosphorylase | 0.0056 | 0.117 | 0.09 |
Echinococcus granulosus | glycogen phosphorylase | 0.013 | 1 | 1 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0107 | 0.7213 | 0.7128 |
Echinococcus granulosus | glycogen phosphorylase | 0.013 | 1 | 1 |
Chlamydia trachomatis | glycogen phosphorylase | 0.013 | 1 | 0.5 |
Echinococcus multilocularis | sodium channel protein | 0.0049 | 0.034 | 0.034 |
Brugia malayi | hypothetical protein | 0.0111 | 0.7713 | 0.7644 |
Echinococcus granulosus | shaker cognate | 0.0059 | 0.1448 | 0.1448 |
Loa Loa (eye worm) | glycogen phosphorylase | 0.013 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 0.048 uM | Inhibition of human hepatic recombinant glycogen phosphorylase by multienzyme coupled assay | ChEMBL. | 17095214 |
IC50 (binding) | = 0.048 uM | Inhibition of human hepatic recombinant glycogen phosphorylase by multienzyme coupled assay | ChEMBL. | 17095214 |
IC50 (functional) | = 6 uM | Inhibition of glucose output in glucagon challenged primary rat hepatocytes | ChEMBL. | 17095214 |
PPB (ADMET) | = 1.11 % | Plasma protein binding | ChEMBL. | 17095214 |
Solubility | = 1.2 uM | Solubility in water | ChEMBL. | 17095214 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.