Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | progesterone receptor | Starlite/ChEMBL | References |
Homo sapiens | nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | Lysosomal Pro X carboxypeptidase | 0.0039 | 0.13 | 0.13 |
Trichomonas vaginalis | Clan SC, family S28, unassigned serine peptidase | 0.0039 | 0.13 | 0.5 |
Toxoplasma gondii | serine carboxypeptidase s28 protein | 0.0039 | 0.13 | 0.5 |
Trichomonas vaginalis | Clan SC, family S28, unassigned serine peptidase | 0.0039 | 0.13 | 0.5 |
Trichomonas vaginalis | prolylcarboxypeptidase, putative | 0.0039 | 0.13 | 0.5 |
Giardia lamblia | Thymus-specific serine protease precursor | 0.0039 | 0.13 | 0.5 |
Schistosoma mansoni | lysosomal Pro-Xaa carboxypeptidase (S28 family) | 0.018 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.018 | 1 | 1 |
Trichomonas vaginalis | Clan SC, family S28, unassigned serine peptidase | 0.0039 | 0.13 | 0.5 |
Entamoeba histolytica | serine carboxypeptidase (S28) family protein | 0.0039 | 0.13 | 0.5 |
Trichomonas vaginalis | prolylcarboxypeptidase, putative | 0.0039 | 0.13 | 0.5 |
Trichomonas vaginalis | Clan SC, family S28, unassigned serine peptidase | 0.0039 | 0.13 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0039 | 0.13 | 0.13 |
Trypanosoma cruzi | serine carboxypeptidase S28, putative | 0.0039 | 0.13 | 0.5 |
Entamoeba histolytica | serine carboxypeptidase (S28) family protein | 0.0039 | 0.13 | 0.5 |
Trichomonas vaginalis | Clan SC, family S28, unassigned serine peptidase | 0.0039 | 0.13 | 0.5 |
Trichomonas vaginalis | Clan SC, family S28, unassigned serine peptidase | 0.0039 | 0.13 | 0.5 |
Trypanosoma cruzi | serine carboxypeptidase S28, putative | 0.0039 | 0.13 | 0.5 |
Giardia lamblia | Serine peptidase, putative | 0.0039 | 0.13 | 0.5 |
Trichomonas vaginalis | Clan SC, family S28, unassigned serine peptidase | 0.0039 | 0.13 | 0.5 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0039 | 0.13 | 0.5 |
Brugia malayi | Serine protease Z688.6 precursor | 0.0039 | 0.13 | 0.13 |
Loa Loa (eye worm) | hypothetical protein | 0.018 | 1 | 1 |
Trichomonas vaginalis | Clan SC, family S28, unassigned serine peptidase | 0.0039 | 0.13 | 0.5 |
Trichomonas vaginalis | Clan SC, family S28, unassigned serine peptidase | 0.0039 | 0.13 | 0.5 |
Trichomonas vaginalis | Clan SC, family S28, unassigned serine peptidase | 0.0039 | 0.13 | 0.5 |
Echinococcus multilocularis | Lysosomal Pro X carboxypeptidase | 0.0039 | 0.13 | 0.13 |
Trichomonas vaginalis | Clan SC, family S28, unassigned serine peptidase | 0.0039 | 0.13 | 0.5 |
Echinococcus multilocularis | Lysosomal Pro X carboxypeptidase | 0.018 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.018 | 1 | 1 |
Trypanosoma cruzi | putative prolyl carboxypeptidase, putative | 0.0039 | 0.13 | 0.5 |
Brugia malayi | Serine protease Z688.6 precursor | 0.0039 | 0.13 | 0.13 |
Schistosoma mansoni | family S28 unassigned peptidase (S28 family) | 0.0039 | 0.13 | 0.13 |
Entamoeba histolytica | serine carboxypeptidase (S28) family protein | 0.0039 | 0.13 | 0.5 |
Echinococcus granulosus | Lysosomal Pro X carboxypeptidase | 0.018 | 1 | 1 |
Onchocerca volvulus | 0.0039 | 0.13 | 1 | |
Trichomonas vaginalis | lysosomal pro-X carboxypeptidase, putative | 0.0039 | 0.13 | 0.5 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0039 | 0.13 | 0.5 |
Trichomonas vaginalis | Clan SC, family S28, unassigned serine peptidase | 0.0039 | 0.13 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | = 39 nM | Antagonist activity at human progesterone receptor assessed as inhibition of alkaline phosphatase activity in human T47D cells | ChEMBL. | 17317167 |
IC50 (functional) | = 39 nM | Antagonist activity at human progesterone receptor assessed as inhibition of alkaline phosphatase activity in human T47D cells | ChEMBL. | 17317167 |
IC50 (functional) | = 246.5 nM | Antagonist activity at human glucocorticoid receptor assessed as inhibition of corticoid-induced transcription in human A549 cells by GRE-linked luciferase reporter gene assay | ChEMBL. | 17317167 |
IC50 (functional) | = 246.5 nM | Antagonist activity at human glucocorticoid receptor assessed as inhibition of corticoid-induced transcription in human A549 cells by GRE-linked luciferase reporter gene assay | ChEMBL. | 17317167 |
Ratio IC50 (binding) | = 6 | Selectivity of human progesterone receptor over human glucocorticoid receptor | ChEMBL. | 17317167 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.