Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | phosphorylase, glycogen, liver | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Leishmania major | C-8 sterol isomerase-like protein | 0.0364 | 1 | 0.5 |
Trichomonas vaginalis | glycogen phosphorylase, putative | 0.013 | 0.3267 | 1 |
Trypanosoma cruzi | C-8 sterol isomerase, putative | 0.0364 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0186 | 0.487 | 0.487 |
Schistosoma mansoni | voltage-gated potassium channel | 0.004 | 0.0664 | 0.2031 |
Echinococcus multilocularis | Glycosyl transferase, family 35 | 0.013 | 0.3267 | 1 |
Echinococcus multilocularis | glycogen phosphorylase | 0.013 | 0.3267 | 1 |
Schistosoma mansoni | glycogen phosphorylase | 0.013 | 0.3267 | 1 |
Entamoeba histolytica | glycogen phosphorylase, putative | 0.013 | 0.3267 | 1 |
Echinococcus multilocularis | potassium voltage gated channel subfamily H | 0.0037 | 0.0566 | 0.1733 |
Schistosoma mansoni | voltage-gated potassium channel | 0.004 | 0.0664 | 0.2031 |
Echinococcus granulosus | glycogen phosphorylase | 0.013 | 0.3267 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0032 | 0.0426 | 0.0426 |
Echinococcus multilocularis | glycogen phosphorylase | 0.013 | 0.3267 | 1 |
Trypanosoma brucei | C-8 sterol isomerase, putative | 0.0364 | 1 | 0.5 |
Echinococcus granulosus | glycogen phosphorylase | 0.013 | 0.3267 | 1 |
Mycobacterium tuberculosis | Probable glycogen phosphorylase GlgP | 0.0056 | 0.1133 | 0.5 |
Trichomonas vaginalis | glycogen phosphorylase, putative | 0.013 | 0.3267 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0364 | 1 | 1 |
Brugia malayi | Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog | 0.0037 | 0.0566 | 0.0566 |
Entamoeba histolytica | glycogen phosphorylase, putative | 0.013 | 0.3267 | 1 |
Chlamydia trachomatis | glycogen phosphorylase | 0.013 | 0.3267 | 0.5 |
Loa Loa (eye worm) | voltage and ligand gated potassium channel | 0.0037 | 0.0566 | 0.0566 |
Echinococcus granulosus | potassium voltage gated channel subfamily H | 0.0037 | 0.0566 | 0.1733 |
Giardia lamblia | Glycogen phosphorylase | 0.013 | 0.3267 | 0.5 |
Loa Loa (eye worm) | glycogen phosphorylase | 0.013 | 0.3267 | 0.3267 |
Mycobacterium ulcerans | glycogen phosphorylase GlgP | 0.0056 | 0.1133 | 0.5 |
Brugia malayi | carbohydrate phosphorylase | 0.013 | 0.3267 | 0.3267 |
Schistosoma mansoni | glycogen phosphorylase | 0.013 | 0.3267 | 1 |
Echinococcus granulosus | Glycosyl transferase family 35 | 0.013 | 0.3267 | 1 |
Schistosoma mansoni | glycogen phosphorylase | 0.0056 | 0.1133 | 0.3467 |
Onchocerca volvulus | Glycogen phosphorylase homolog | 0.013 | 0.3267 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | 0 | Inhibition of glucose output in glucagon challenged primary rat hepatocytes | ChEMBL. | 17095214 |
IC50 (binding) | = 0.709 uM | Inhibition of human hepatic recombinant glycogen phosphorylase by multienzyme coupled assay | ChEMBL. | 17095214 |
IC50 (binding) | = 0.709 uM | Inhibition of human hepatic recombinant glycogen phosphorylase by multienzyme coupled assay | ChEMBL. | 17095214 |
PPB (ADMET) | = 1.83 % | Plasma protein binding | ChEMBL. | 17095214 |
Solubility | = 0.13 uM | Solubility in water | ChEMBL. | 17095214 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.