Detailed information for compound 439397

Basic information

Technical information
  • TDR Targets ID: 439397
  • Name: methyl 2-[[(2S)-4-(2,5-dioxopyrrol-1-yl)-2-(p henylmethoxycarbonylamino)butanoyl]amino]acet ate
  • MW: 403.386 | Formula: C19H21N3O7
  • H donors: 2 H acceptors: 5 LogP: 0.35 Rotable bonds: 13
    Rule of 5 violations (Lipinski): 1
  • SMILES: COC(=O)CNC(=O)[C@@H](NC(=O)OCc1ccccc1)CCN1C(=O)C=CC1=O
  • InChi: 1S/C19H21N3O7/c1-28-17(25)11-20-18(26)14(9-10-22-15(23)7-8-16(22)24)21-19(27)29-12-13-5-3-2-4-6-13/h2-8,14H,9-12H2,1H3,(H,20,26)(H,21,27)/t14-/m0/s1
  • InChiKey: QFHVCZFXVAVRSV-AWEZNQCLSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • methyl 2-[[(2S)-2-(benzyloxycarbonylamino)-4-(2,5-dioxopyrrol-1-yl)butanoyl]amino]acetate
  • 2-[[(2S)-2-(benzyloxycarbonylamino)-4-(2,5-dioxo-1-pyrrolyl)-1-oxobutyl]amino]acetic acid methyl ester
  • methyl 2-[[(2S)-4-(2,5-dioxopyrrol-1-yl)-2-(phenylmethoxycarbonylamino)butanoyl]amino]ethanoate
  • 2-[[(2S)-2-(benzyloxycarbonylamino)-4-maleimido-butanoyl]amino]acetic acid methyl ester
  • 2-[[(2S)-4-(2,5-dioxo-1-pyrrolyl)-1-oxo-2-[[oxo-(phenylmethoxy)methyl]amino]butyl]amino]acetic acid methyl ester

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) hypothetical protein 0.0005 0.3236 0.5
Schistosoma mansoni neuropeptide f receptor 76f 0.0005 0.3236 0.5
Echinococcus granulosus neuropeptide receptor A26 0.0005 0.3236 0.5
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0005 0.3236 0.5
Loa Loa (eye worm) hypothetical protein 0.0005 0.3236 0.5
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0005 0.3236 0.5
Echinococcus granulosus rhodopsin orphan GPCR 0.0005 0.3236 0.5
Echinococcus multilocularis rhodopsin orphan GPCR 0.0005 0.3236 0.5
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0005 0.3236 0.5
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0005 0.3236 0.5
Schistosoma mansoni opsin-like receptor 0.0005 0.3236 0.5
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0005 0.3236 0.5
Loa Loa (eye worm) hypothetical protein 0.0005 0.3236 0.5
Onchocerca volvulus 0.0005 0.3236 0.5
Echinococcus granulosus neuropeptides capa receptor 0.0005 0.3236 0.5
Echinococcus granulosus neuropeptide Y receptor 0.0005 0.3236 0.5
Loa Loa (eye worm) hypothetical protein 0.0005 0.3236 0.5
Echinococcus granulosus rhodopsin orphan GPCR 0.0005 0.3236 0.5
Echinococcus multilocularis serotonin receptor 0.0005 0.3236 0.5
Schistosoma mansoni adenoreceptor 0.0005 0.3236 0.5
Loa Loa (eye worm) hypothetical protein 0.0005 0.3236 0.5
Loa Loa (eye worm) hypothetical protein 0.0005 0.3236 0.5
Loa Loa (eye worm) hypothetical protein 0.0005 0.3236 0.5
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0005 0.3236 0.5
Loa Loa (eye worm) hypothetical protein 0.0005 0.3236 0.5
Schistosoma mansoni alpha-1 adrenergic receptor 0.0005 0.3236 0.5
Brugia malayi Dopamine receptor 0.0005 0.3236 0.5
Echinococcus multilocularis g-protein coupled receptor 0.0005 0.3236 0.5
Echinococcus granulosus 7tm_1 domain containing protein 0.0005 0.3236 0.5
Schistosoma mansoni amine GPCR 0.0005 0.3236 0.5
Loa Loa (eye worm) hypothetical protein 0.0005 0.3236 0.5
Loa Loa (eye worm) hypothetical protein 0.0005 0.3236 0.5
Echinococcus granulosus rhodopsin orphan GPCR 0.0005 0.3236 0.5
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0005 0.3236 0.5
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0005 0.3236 0.5
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0005 0.3236 0.5
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0005 0.3236 0.5
Loa Loa (eye worm) hypothetical protein 0.0005 0.3236 0.5
Loa Loa (eye worm) hypothetical protein 0.0005 0.3236 0.5
Loa Loa (eye worm) hypothetical protein 0.0005 0.3236 0.5
Echinococcus granulosus neuropeptide receptor 0.0005 0.3236 0.5
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0005 0.3236 0.5
Echinococcus granulosus neuropeptide FF receptor 2 0.0005 0.3236 0.5
Schistosoma mansoni neuropeptide receptor 0.0005 0.3236 0.5
Loa Loa (eye worm) hypothetical protein 0.0005 0.3236 0.5
Loa Loa (eye worm) hypothetical protein 0.0005 0.3236 0.5
Loa Loa (eye worm) hypothetical protein 0.0005 0.3236 0.5
Echinococcus multilocularis rhodopsin orphan GPCR 0.0005 0.3236 0.5
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0005 0.3236 0.5
Loa Loa (eye worm) hypothetical protein 0.0005 0.3236 0.5
Brugia malayi hypothetical protein 0.0005 0.3236 0.5
Onchocerca volvulus 0.0005 0.3236 0.5
Echinococcus multilocularis neuropeptide Y receptor 0.0005 0.3236 0.5
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0005 0.3236 0.5
Loa Loa (eye worm) hypothetical protein 0.0005 0.3236 0.5
Onchocerca volvulus 0.0005 0.3236 0.5
Onchocerca volvulus 0.0005 0.3236 0.5
Echinococcus multilocularis serotonin receptor 0.0005 0.3236 0.5
Brugia malayi hypothetical protein 0.0005 0.3236 0.5
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0005 0.3236 0.5
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0005 0.3236 0.5
Brugia malayi RE15519p 0.0005 0.3236 0.5
Schistosoma mansoni opsin-like receptor 0.0005 0.3236 0.5
Onchocerca volvulus 0.0005 0.3236 0.5
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0005 0.3236 0.5
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0005 0.3236 0.5
Loa Loa (eye worm) G-protein coupled receptor 0.0005 0.3236 0.5
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0005 0.3236 0.5
Brugia malayi putative neuropeptide receptor NPR1 0.0005 0.3236 0.5
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0005 0.3236 0.5
Loa Loa (eye worm) neuropeptide F receptor 0.0005 0.3236 0.5
Echinococcus multilocularis fmrfamide receptor 0.0005 0.3236 0.5
Loa Loa (eye worm) hypothetical protein 0.0005 0.3236 0.5
Leishmania major hypothetical protein, conserved 0.0002 0 0.5
Schistosoma mansoni growth hormone secretagogue receptor 0.0005 0.3236 0.5
Schistosoma mansoni neuropeptide receptor 0.0005 0.3236 0.5
Brugia malayi Serotonin receptor 0.0005 0.3236 0.5
Echinococcus granulosus g protein coupled receptor 0.0005 0.3236 0.5
Loa Loa (eye worm) melatonin receptor type 1A 0.0005 0.3236 0.5
Echinococcus granulosus tm gpcr rhodopsin 0.0005 0.3236 0.5
Echinococcus granulosus rhodopsin orphan GPCR 0.0005 0.3236 0.5
Echinococcus granulosus 7TM GPCR rhodopsin 0.0005 0.3236 0.5
Loa Loa (eye worm) TYRA-2 protein 0.0005 0.3236 0.5
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0005 0.3236 0.5
Loa Loa (eye worm) hypothetical protein 0.0005 0.3236 0.5
Onchocerca volvulus 0.0005 0.3236 0.5
Echinococcus multilocularis neuropeptide FF receptor 2 0.0005 0.3236 0.5
Loa Loa (eye worm) hypothetical protein 0.0005 0.3236 0.5
Brugia malayi larval opioid receptor 0.0005 0.3236 0.5
Brugia malayi hypothetical protein 0.0005 0.3236 0.5
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0005 0.3236 0.5
Echinococcus granulosus fmrfamide receptor 0.0005 0.3236 0.5
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0005 0.3236 0.5
Loa Loa (eye worm) hypothetical protein 0.0005 0.3236 0.5
Onchocerca volvulus 0.0005 0.3236 0.5
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0005 0.3236 0.5
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0005 0.3236 0.5
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0005 0.3236 0.5
Echinococcus multilocularis fmrfamide receptor 0.0005 0.3236 0.5
Echinococcus granulosus neuropeptide Y receptor 0.0005 0.3236 0.5
Echinococcus multilocularis allatostatin A receptor 0.0005 0.3236 0.5
Echinococcus granulosus orexin receptor type 2 0.0005 0.3236 0.5
Brugia malayi hypothetical protein 0.0005 0.3236 0.5
Onchocerca volvulus 0.0005 0.3236 0.5
Onchocerca volvulus Neuropeptide F receptor homolog 0.0005 0.3236 0.5
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0005 0.3236 0.5
Echinococcus multilocularis rhodopsin orphan GPCR 0.0005 0.3236 0.5
Brugia malayi hypothetical protein 0.0005 0.3236 0.5
Loa Loa (eye worm) hypothetical protein 0.0005 0.3236 0.5
Echinococcus multilocularis rhodopsin orphan GPCR 0.0005 0.3236 0.5
Echinococcus multilocularis g protein coupled receptor 0.0005 0.3236 0.5
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0005 0.3236 0.5
Loa Loa (eye worm) hypothetical protein 0.0005 0.3236 0.5
Echinococcus granulosus somatostatin receptor 0.0005 0.3236 0.5
Loa Loa (eye worm) hypothetical protein 0.0005 0.3236 0.5
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0005 0.3236 0.5
Loa Loa (eye worm) hypothetical protein 0.0005 0.3236 0.5
Echinococcus multilocularis orexin receptor type 2 0.0005 0.3236 0.5
Onchocerca volvulus 0.0005 0.3236 0.5
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0005 0.3236 0.5
Brugia malayi neuropeptide F receptor 0.0005 0.3236 0.5
Onchocerca volvulus 0.0005 0.3236 0.5
Schistosoma mansoni opsin-like receptor 0.0005 0.3236 0.5
Echinococcus granulosus g protein coupled receptor 0.0005 0.3236 0.5
Brugia malayi hypothetical protein 0.0005 0.3236 0.5
Loa Loa (eye worm) hypothetical protein 0.0005 0.3236 0.5
Schistosoma mansoni neuropeptide receptor 0.0005 0.3236 0.5
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0005 0.3236 0.5
Loa Loa (eye worm) hypothetical protein 0.0005 0.3236 0.5
Brugia malayi sulfakinin receptor protein 0.0005 0.3236 0.5
Brugia malayi follicle stimulating hormone receptor 0.0005 0.3236 0.5
Schistosoma mansoni biogenic amine (5HT) receptor 0.0005 0.3236 0.5
Echinococcus granulosus neuropeptide s receptor 0.0005 0.3236 0.5
Schistosoma mansoni hypothetical protein 0.0005 0.3236 0.5
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0005 0.3236 0.5
Onchocerca volvulus 0.0005 0.3236 0.5
Echinococcus granulosus g protein coupled receptor 0.0005 0.3236 0.5
Schistosoma mansoni amine GPCR 0.0005 0.3236 0.5
Loa Loa (eye worm) hypothetical protein 0.0005 0.3236 0.5
Brugia malayi GnHR receptor homolog 0.0005 0.3236 0.5
Onchocerca volvulus 0.0005 0.3236 0.5
Mycobacterium ulcerans oxidase 0.001 1 0.5
Echinococcus multilocularis neuropeptide receptor A26 0.0005 0.3236 0.5
Echinococcus granulosus sex peptide receptor 0.0005 0.3236 0.5
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0005 0.3236 0.5
Echinococcus multilocularis neuropeptides capa receptor 0.0005 0.3236 0.5
Loa Loa (eye worm) hypothetical protein 0.0005 0.3236 0.5
Echinococcus granulosus neuropeptides capa receptor 0.0005 0.3236 0.5
Echinococcus multilocularis rhodopsin orphan GPCR 0.0005 0.3236 0.5
Loa Loa (eye worm) hypothetical protein 0.0005 0.3236 0.5
Echinococcus multilocularis g protein coupled receptor 0.0005 0.3236 0.5
Brugia malayi neuropeptide F receptor 0.0005 0.3236 0.5
Schistosoma mansoni neuropeptide receptor 0.0005 0.3236 0.5
Schistosoma mansoni neuropeptide F-like receptor 0.0005 0.3236 0.5
Echinococcus multilocularis G protein coupled receptor 139 0.0005 0.3236 0.5
Schistosoma mansoni hypothetical protein 0.0005 0.3236 0.5
Echinococcus multilocularis G-protein coupled receptor, putative 0.0005 0.3236 0.5
Echinococcus granulosus g-protein coupled receptor 0.0005 0.3236 0.5
Brugia malayi AKH receptor 0.0005 0.3236 0.5
Echinococcus granulosus allatostatin A receptor 0.0005 0.3236 0.5
Schistosoma mansoni amine GPCR 0.0005 0.3236 0.5
Brugia malayi putative neuropeptide receptor 0.0005 0.3236 0.5
Trypanosoma brucei hypothetical protein, conserved 0.0002 0 0.5
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0005 0.3236 0.5
Trypanosoma brucei multicopper oxidase, putative 0.0002 0 0.5
Echinococcus granulosus alpha 1A adrenergic receptor 0.0005 0.3236 0.5
Trypanosoma cruzi multicopper oxidase, putative 0.0002 0 0.5
Echinococcus multilocularis dro:myosuppressin receptor 0.0005 0.3236 0.5
Brugia malayi Serotonin receptor 0.0005 0.3236 0.5
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0005 0.3236 0.5
Echinococcus granulosus tm gpcr rhodopsin 0.0005 0.3236 0.5
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0005 0.3236 0.5
Echinococcus granulosus tm gpcr rhodopsin 0.0005 0.3236 0.5
Schistosoma mansoni neuropeptide F-like receptor 0.0005 0.3236 0.5
Brugia malayi Dopamine receptor protein 1 0.0005 0.3236 0.5
Loa Loa (eye worm) hypothetical protein 0.0005 0.3236 0.5
Echinococcus granulosus G protein coupled receptor 139 0.0005 0.3236 0.5
Echinococcus multilocularis neuropeptide receptor 0.0005 0.3236 0.5
Echinococcus granulosus dro:myosuppressin receptor 0.0005 0.3236 0.5
Brugia malayi G protein-coupled receptor F59B2.13 0.0005 0.3236 0.5
Echinococcus multilocularis neuropeptide Y receptor 0.0005 0.3236 0.5
Schistosoma mansoni biogenic amine receptor 0.0005 0.3236 0.5
Brugia malayi hypothetical protein 0.0005 0.3236 0.5
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0005 0.3236 0.5
Echinococcus granulosus biogenic amine 5HT receptor 0.0005 0.3236 0.5
Onchocerca volvulus 0.0005 0.3236 0.5
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0005 0.3236 0.5
Loa Loa (eye worm) hypothetical protein 0.0005 0.3236 0.5
Brugia malayi G protein-coupled receptor 0.0005 0.3236 0.5
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0005 0.3236 0.5
Loa Loa (eye worm) hypothetical protein 0.0005 0.3236 0.5
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0005 0.3236 0.5
Trypanosoma cruzi multicopper oxidase, putative 0.0002 0 0.5
Loa Loa (eye worm) hypothetical protein 0.0005 0.3236 0.5
Loa Loa (eye worm) hypothetical protein 0.0005 0.3236 0.5
Loa Loa (eye worm) hypothetical protein 0.0005 0.3236 0.5
Echinococcus granulosus hypothetical protein 0.0005 0.3236 0.5
Loa Loa (eye worm) hypothetical protein 0.0005 0.3236 0.5
Loa Loa (eye worm) hypothetical protein 0.0005 0.3236 0.5
Schistosoma mansoni histamine h1 receptor 0.0005 0.3236 0.5
Echinococcus granulosus biogenic amine 5HT receptor 0.0005 0.3236 0.5
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0005 0.3236 0.5
Echinococcus multilocularis sex peptide receptor 0.0005 0.3236 0.5
Echinococcus granulosus rhodopsin orphan GPCR 0.0005 0.3236 0.5
Brugia malayi G-protein coupled receptor 0.0005 0.3236 0.5
Echinococcus granulosus tachykinin peptides receptor 99D 0.0005 0.3236 0.5
Onchocerca volvulus 0.0005 0.3236 0.5
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0005 0.3236 0.5
Brugia malayi hypothetical protein 0.0005 0.3236 0.5
Echinococcus multilocularis neuropeptides capa receptor 0.0005 0.3236 0.5
Onchocerca volvulus 0.0005 0.3236 0.5
Echinococcus multilocularis g protein coupled receptor 0.0005 0.3236 0.5
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0005 0.3236 0.5
Brugia malayi Melatonin receptor type 1A 0.0005 0.3236 0.5
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0005 0.3236 0.5
Schistosoma mansoni biogenic amine (5HT) receptor 0.0005 0.3236 0.5
Onchocerca volvulus 0.0005 0.3236 0.5
Schistosoma mansoni hypothetical protein 0.0005 0.3236 0.5
Echinococcus multilocularis neuropeptide s receptor 0.0005 0.3236 0.5
Echinococcus granulosus serotonin receptor 0.0005 0.3236 0.5
Schistosoma mansoni amine GPCR 0.0005 0.3236 0.5
Brugia malayi hypothetical protein 0.0005 0.3236 0.5
Echinococcus multilocularis neuropeptide receptor 0.0005 0.3236 0.5
Loa Loa (eye worm) hypothetical protein 0.0005 0.3236 0.5
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0005 0.3236 0.5
Loa Loa (eye worm) hypothetical protein 0.0005 0.3236 0.5
Loa Loa (eye worm) hypothetical protein 0.0005 0.3236 0.5
Schistosoma mansoni myosin xvIII 0.0005 0.3236 0.5
Onchocerca volvulus 0.0005 0.3236 0.5
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0005 0.3236 0.5
Loa Loa (eye worm) hypothetical protein 0.0005 0.3236 0.5
Schistosoma mansoni biogenic amine receptor 0.0005 0.3236 0.5
Brugia malayi hypothetical protein 0.0005 0.3236 0.5
Schistosoma mansoni biogenic amine receptor 0.0005 0.3236 0.5
Brugia malayi G-protein coupled receptor 0.0005 0.3236 0.5
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0005 0.3236 0.5
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0005 0.3236 0.5
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0005 0.3236 0.5
Echinococcus multilocularis somatostatin receptor 0.0005 0.3236 0.5
Brugia malayi Dopamine receptor protein 2 0.0005 0.3236 0.5
Echinococcus granulosus neuropeptide receptor 0.0005 0.3236 0.5
Brugia malayi Tachykinin-like peptides receptor 99D 0.0005 0.3236 0.5
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0005 0.3236 0.5
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0005 0.3236 0.5
Loa Loa (eye worm) hypothetical protein 0.0005 0.3236 0.5
Echinococcus granulosus rhodopsin orphan GPCR 0.0005 0.3236 0.5
Echinococcus multilocularis rhodopsin orphan GPCR 0.0005 0.3236 0.5
Loa Loa (eye worm) hypothetical protein 0.0005 0.3236 0.5
Schistosoma mansoni hypothetical protein 0.0005 0.3236 0.5
Echinococcus multilocularis rhodopsin orphan GPCR 0.0005 0.3236 0.5
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0005 0.3236 0.5
Loa Loa (eye worm) neuropeptide F receptor 0.0005 0.3236 0.5
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0005 0.3236 0.5
Loa Loa (eye worm) G-protein coupled receptor 0.0005 0.3236 0.5
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0005 0.3236 0.5
Echinococcus multilocularis rhodopsin orphan GPCR 0.0005 0.3236 0.5
Echinococcus granulosus rhodopsin orphan GPCR 0.0005 0.3236 0.5
Schistosoma mansoni amine GPCR 0.0005 0.3236 0.5
Brugia malayi ORL1-like opioid receptor 0.0005 0.3236 0.5
Echinococcus granulosus peptide allatostatin:somatostatin 0.0005 0.3236 0.5

Activities

Activity type Activity value Assay description Source Reference
Ratio (binding) = 0.28 /mM/min Ratio of Kinactivation to KI of guinea pig recombinant liver TGase expressed in Escherichia coli ChEMBL. 17092716

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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