Detailed information for compound 439397

Basic information

Technical information
  • TDR Targets ID: 439397
  • Name: methyl 2-[[(2S)-4-(2,5-dioxopyrrol-1-yl)-2-(p henylmethoxycarbonylamino)butanoyl]amino]acet ate
  • MW: 403.386 | Formula: C19H21N3O7
  • H donors: 2 H acceptors: 5 LogP: 0.35 Rotable bonds: 13
    Rule of 5 violations (Lipinski): 1
  • SMILES: COC(=O)CNC(=O)[C@@H](NC(=O)OCc1ccccc1)CCN1C(=O)C=CC1=O
  • InChi: 1S/C19H21N3O7/c1-28-17(25)11-20-18(26)14(9-10-22-15(23)7-8-16(22)24)21-19(27)29-12-13-5-3-2-4-6-13/h2-8,14H,9-12H2,1H3,(H,20,26)(H,21,27)/t14-/m0/s1
  • InChiKey: QFHVCZFXVAVRSV-AWEZNQCLSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • methyl 2-[[(2S)-2-(benzyloxycarbonylamino)-4-(2,5-dioxopyrrol-1-yl)butanoyl]amino]acetate
  • 2-[[(2S)-2-(benzyloxycarbonylamino)-4-(2,5-dioxo-1-pyrrolyl)-1-oxobutyl]amino]acetic acid methyl ester
  • methyl 2-[[(2S)-4-(2,5-dioxopyrrol-1-yl)-2-(phenylmethoxycarbonylamino)butanoyl]amino]ethanoate
  • 2-[[(2S)-2-(benzyloxycarbonylamino)-4-maleimido-butanoyl]amino]acetic acid methyl ester
  • 2-[[(2S)-4-(2,5-dioxo-1-pyrrolyl)-1-oxo-2-[[oxo-(phenylmethoxy)methyl]amino]butyl]amino]acetic acid methyl ester

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) neuropeptide F receptor 0.0005 0.3236 0.5
Schistosoma mansoni hypothetical protein 0.0005 0.3236 0.5
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0005 0.3236 0.5
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0005 0.3236 0.5
Echinococcus multilocularis serotonin receptor 0.0005 0.3236 0.5
Leishmania major hypothetical protein, conserved 0.0002 0 0.5
Loa Loa (eye worm) hypothetical protein 0.0005 0.3236 0.5
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0005 0.3236 0.5
Echinococcus granulosus rhodopsin orphan GPCR 0.0005 0.3236 0.5
Brugia malayi Tachykinin-like peptides receptor 99D 0.0005 0.3236 0.5
Loa Loa (eye worm) hypothetical protein 0.0005 0.3236 0.5
Loa Loa (eye worm) hypothetical protein 0.0005 0.3236 0.5
Echinococcus multilocularis neuropeptides capa receptor 0.0005 0.3236 0.5
Schistosoma mansoni amine GPCR 0.0005 0.3236 0.5
Brugia malayi Dopamine receptor protein 1 0.0005 0.3236 0.5
Brugia malayi hypothetical protein 0.0005 0.3236 0.5
Echinococcus granulosus neuropeptides capa receptor 0.0005 0.3236 0.5
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0005 0.3236 0.5
Echinococcus granulosus g-protein coupled receptor 0.0005 0.3236 0.5
Schistosoma mansoni alpha-1 adrenergic receptor 0.0005 0.3236 0.5
Onchocerca volvulus 0.0005 0.3236 0.5
Loa Loa (eye worm) hypothetical protein 0.0005 0.3236 0.5
Onchocerca volvulus 0.0005 0.3236 0.5
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0005 0.3236 0.5
Loa Loa (eye worm) hypothetical protein 0.0005 0.3236 0.5
Onchocerca volvulus 0.0005 0.3236 0.5
Loa Loa (eye worm) hypothetical protein 0.0005 0.3236 0.5
Echinococcus granulosus rhodopsin orphan GPCR 0.0005 0.3236 0.5
Echinococcus granulosus rhodopsin orphan GPCR 0.0005 0.3236 0.5
Echinococcus multilocularis G protein coupled receptor 139 0.0005 0.3236 0.5
Echinococcus multilocularis g protein coupled receptor 0.0005 0.3236 0.5
Brugia malayi larval opioid receptor 0.0005 0.3236 0.5
Onchocerca volvulus 0.0005 0.3236 0.5
Echinococcus multilocularis neuropeptide FF receptor 2 0.0005 0.3236 0.5
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0005 0.3236 0.5
Onchocerca volvulus 0.0005 0.3236 0.5
Echinococcus multilocularis neuropeptide receptor A26 0.0005 0.3236 0.5
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0005 0.3236 0.5
Brugia malayi neuropeptide F receptor 0.0005 0.3236 0.5
Onchocerca volvulus 0.0005 0.3236 0.5
Schistosoma mansoni opsin-like receptor 0.0005 0.3236 0.5
Trypanosoma cruzi multicopper oxidase, putative 0.0002 0 0.5
Echinococcus multilocularis rhodopsin orphan GPCR 0.0005 0.3236 0.5
Loa Loa (eye worm) hypothetical protein 0.0005 0.3236 0.5
Brugia malayi sulfakinin receptor protein 0.0005 0.3236 0.5
Echinococcus multilocularis rhodopsin orphan GPCR 0.0005 0.3236 0.5
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0005 0.3236 0.5
Echinococcus granulosus neuropeptide Y receptor 0.0005 0.3236 0.5
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0005 0.3236 0.5
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0005 0.3236 0.5
Schistosoma mansoni biogenic amine receptor 0.0005 0.3236 0.5
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0005 0.3236 0.5
Loa Loa (eye worm) hypothetical protein 0.0005 0.3236 0.5
Loa Loa (eye worm) melatonin receptor type 1A 0.0005 0.3236 0.5
Brugia malayi G protein-coupled receptor 0.0005 0.3236 0.5
Echinococcus granulosus g protein coupled receptor 0.0005 0.3236 0.5
Loa Loa (eye worm) hypothetical protein 0.0005 0.3236 0.5
Onchocerca volvulus 0.0005 0.3236 0.5
Loa Loa (eye worm) hypothetical protein 0.0005 0.3236 0.5
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0005 0.3236 0.5
Echinococcus granulosus 7tm_1 domain containing protein 0.0005 0.3236 0.5
Schistosoma mansoni hypothetical protein 0.0005 0.3236 0.5
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0005 0.3236 0.5
Onchocerca volvulus 0.0005 0.3236 0.5
Onchocerca volvulus 0.0005 0.3236 0.5
Echinococcus granulosus rhodopsin orphan GPCR 0.0005 0.3236 0.5
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0005 0.3236 0.5
Trypanosoma brucei multicopper oxidase, putative 0.0002 0 0.5
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0005 0.3236 0.5
Schistosoma mansoni myosin xvIII 0.0005 0.3236 0.5
Echinococcus multilocularis rhodopsin orphan GPCR 0.0005 0.3236 0.5
Echinococcus multilocularis fmrfamide receptor 0.0005 0.3236 0.5
Onchocerca volvulus 0.0005 0.3236 0.5
Echinococcus multilocularis g protein coupled receptor 0.0005 0.3236 0.5
Schistosoma mansoni growth hormone secretagogue receptor 0.0005 0.3236 0.5
Brugia malayi hypothetical protein 0.0005 0.3236 0.5
Loa Loa (eye worm) hypothetical protein 0.0005 0.3236 0.5
Echinococcus granulosus peptide allatostatin:somatostatin 0.0005 0.3236 0.5
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0005 0.3236 0.5
Echinococcus multilocularis rhodopsin orphan GPCR 0.0005 0.3236 0.5
Brugia malayi putative neuropeptide receptor 0.0005 0.3236 0.5
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0005 0.3236 0.5
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0005 0.3236 0.5
Echinococcus multilocularis rhodopsin orphan GPCR 0.0005 0.3236 0.5
Echinococcus granulosus neuropeptide receptor A26 0.0005 0.3236 0.5
Onchocerca volvulus 0.0005 0.3236 0.5
Echinococcus granulosus neuropeptides capa receptor 0.0005 0.3236 0.5
Onchocerca volvulus 0.0005 0.3236 0.5
Schistosoma mansoni neuropeptide receptor 0.0005 0.3236 0.5
Brugia malayi GnHR receptor homolog 0.0005 0.3236 0.5
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0005 0.3236 0.5
Echinococcus multilocularis g-protein coupled receptor 0.0005 0.3236 0.5
Brugia malayi ORL1-like opioid receptor 0.0005 0.3236 0.5
Loa Loa (eye worm) hypothetical protein 0.0005 0.3236 0.5
Loa Loa (eye worm) G-protein coupled receptor 0.0005 0.3236 0.5
Loa Loa (eye worm) hypothetical protein 0.0005 0.3236 0.5
Schistosoma mansoni neuropeptide F-like receptor 0.0005 0.3236 0.5
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0005 0.3236 0.5
Schistosoma mansoni neuropeptide F-like receptor 0.0005 0.3236 0.5
Echinococcus granulosus biogenic amine 5HT receptor 0.0005 0.3236 0.5
Echinococcus granulosus tm gpcr rhodopsin 0.0005 0.3236 0.5
Echinococcus multilocularis G-protein coupled receptor, putative 0.0005 0.3236 0.5
Loa Loa (eye worm) hypothetical protein 0.0005 0.3236 0.5
Brugia malayi RE15519p 0.0005 0.3236 0.5
Onchocerca volvulus 0.0005 0.3236 0.5
Loa Loa (eye worm) hypothetical protein 0.0005 0.3236 0.5
Loa Loa (eye worm) hypothetical protein 0.0005 0.3236 0.5
Echinococcus granulosus neuropeptide FF receptor 2 0.0005 0.3236 0.5
Schistosoma mansoni opsin-like receptor 0.0005 0.3236 0.5
Echinococcus multilocularis somatostatin receptor 0.0005 0.3236 0.5
Onchocerca volvulus Neuropeptide F receptor homolog 0.0005 0.3236 0.5
Loa Loa (eye worm) hypothetical protein 0.0005 0.3236 0.5
Brugia malayi hypothetical protein 0.0005 0.3236 0.5
Loa Loa (eye worm) hypothetical protein 0.0005 0.3236 0.5
Echinococcus granulosus tm gpcr rhodopsin 0.0005 0.3236 0.5
Echinococcus granulosus neuropeptide receptor 0.0005 0.3236 0.5
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0005 0.3236 0.5
Loa Loa (eye worm) hypothetical protein 0.0005 0.3236 0.5
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0005 0.3236 0.5
Schistosoma mansoni hypothetical protein 0.0005 0.3236 0.5
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0005 0.3236 0.5
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0005 0.3236 0.5
Echinococcus multilocularis neuropeptide Y receptor 0.0005 0.3236 0.5
Echinococcus multilocularis orexin receptor type 2 0.0005 0.3236 0.5
Brugia malayi putative neuropeptide receptor NPR1 0.0005 0.3236 0.5
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0005 0.3236 0.5
Mycobacterium ulcerans oxidase 0.001 1 0.5
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0005 0.3236 0.5
Brugia malayi Serotonin receptor 0.0005 0.3236 0.5
Echinococcus granulosus hypothetical protein 0.0005 0.3236 0.5
Trypanosoma brucei hypothetical protein, conserved 0.0002 0 0.5
Loa Loa (eye worm) hypothetical protein 0.0005 0.3236 0.5
Echinococcus granulosus tm gpcr rhodopsin 0.0005 0.3236 0.5
Brugia malayi hypothetical protein 0.0005 0.3236 0.5
Schistosoma mansoni amine GPCR 0.0005 0.3236 0.5
Loa Loa (eye worm) hypothetical protein 0.0005 0.3236 0.5
Brugia malayi Melatonin receptor type 1A 0.0005 0.3236 0.5
Echinococcus granulosus g protein coupled receptor 0.0005 0.3236 0.5
Echinococcus granulosus somatostatin receptor 0.0005 0.3236 0.5
Echinococcus multilocularis sex peptide receptor 0.0005 0.3236 0.5
Echinococcus multilocularis rhodopsin orphan GPCR 0.0005 0.3236 0.5
Loa Loa (eye worm) hypothetical protein 0.0005 0.3236 0.5
Brugia malayi hypothetical protein 0.0005 0.3236 0.5
Brugia malayi Dopamine receptor protein 2 0.0005 0.3236 0.5
Loa Loa (eye worm) hypothetical protein 0.0005 0.3236 0.5
Schistosoma mansoni biogenic amine receptor 0.0005 0.3236 0.5
Echinococcus granulosus rhodopsin orphan GPCR 0.0005 0.3236 0.5
Schistosoma mansoni neuropeptide receptor 0.0005 0.3236 0.5
Schistosoma mansoni amine GPCR 0.0005 0.3236 0.5
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0005 0.3236 0.5
Brugia malayi hypothetical protein 0.0005 0.3236 0.5
Schistosoma mansoni neuropeptide receptor 0.0005 0.3236 0.5
Brugia malayi Serotonin receptor 0.0005 0.3236 0.5
Loa Loa (eye worm) hypothetical protein 0.0005 0.3236 0.5
Echinococcus granulosus alpha 1A adrenergic receptor 0.0005 0.3236 0.5
Echinococcus multilocularis allatostatin A receptor 0.0005 0.3236 0.5
Brugia malayi follicle stimulating hormone receptor 0.0005 0.3236 0.5
Loa Loa (eye worm) hypothetical protein 0.0005 0.3236 0.5
Brugia malayi hypothetical protein 0.0005 0.3236 0.5
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0005 0.3236 0.5
Echinococcus multilocularis neuropeptide receptor 0.0005 0.3236 0.5
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0005 0.3236 0.5
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0005 0.3236 0.5
Echinococcus granulosus neuropeptide s receptor 0.0005 0.3236 0.5
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0005 0.3236 0.5
Brugia malayi hypothetical protein 0.0005 0.3236 0.5
Loa Loa (eye worm) hypothetical protein 0.0005 0.3236 0.5
Loa Loa (eye worm) TYRA-2 protein 0.0005 0.3236 0.5
Loa Loa (eye worm) hypothetical protein 0.0005 0.3236 0.5
Loa Loa (eye worm) hypothetical protein 0.0005 0.3236 0.5
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0005 0.3236 0.5
Trypanosoma cruzi multicopper oxidase, putative 0.0002 0 0.5
Echinococcus multilocularis rhodopsin orphan GPCR 0.0005 0.3236 0.5
Schistosoma mansoni amine GPCR 0.0005 0.3236 0.5
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0005 0.3236 0.5
Echinococcus granulosus 7TM GPCR rhodopsin 0.0005 0.3236 0.5
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0005 0.3236 0.5
Loa Loa (eye worm) G-protein coupled receptor 0.0005 0.3236 0.5
Schistosoma mansoni biogenic amine receptor 0.0005 0.3236 0.5
Echinococcus granulosus neuropeptide Y receptor 0.0005 0.3236 0.5
Loa Loa (eye worm) hypothetical protein 0.0005 0.3236 0.5
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0005 0.3236 0.5
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0005 0.3236 0.5
Brugia malayi hypothetical protein 0.0005 0.3236 0.5
Brugia malayi Dopamine receptor 0.0005 0.3236 0.5
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0005 0.3236 0.5
Loa Loa (eye worm) hypothetical protein 0.0005 0.3236 0.5
Schistosoma mansoni hypothetical protein 0.0005 0.3236 0.5
Schistosoma mansoni amine GPCR 0.0005 0.3236 0.5
Echinococcus granulosus g protein coupled receptor 0.0005 0.3236 0.5
Brugia malayi G-protein coupled receptor 0.0005 0.3236 0.5
Schistosoma mansoni neuropeptide f receptor 76f 0.0005 0.3236 0.5
Loa Loa (eye worm) hypothetical protein 0.0005 0.3236 0.5
Echinococcus multilocularis serotonin receptor 0.0005 0.3236 0.5
Echinococcus granulosus sex peptide receptor 0.0005 0.3236 0.5
Onchocerca volvulus 0.0005 0.3236 0.5
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0005 0.3236 0.5
Schistosoma mansoni opsin-like receptor 0.0005 0.3236 0.5
Loa Loa (eye worm) hypothetical protein 0.0005 0.3236 0.5
Brugia malayi neuropeptide F receptor 0.0005 0.3236 0.5
Echinococcus granulosus fmrfamide receptor 0.0005 0.3236 0.5
Echinococcus granulosus tachykinin peptides receptor 99D 0.0005 0.3236 0.5
Echinococcus multilocularis g protein coupled receptor 0.0005 0.3236 0.5
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0005 0.3236 0.5
Loa Loa (eye worm) hypothetical protein 0.0005 0.3236 0.5
Schistosoma mansoni histamine h1 receptor 0.0005 0.3236 0.5
Echinococcus granulosus serotonin receptor 0.0005 0.3236 0.5
Loa Loa (eye worm) hypothetical protein 0.0005 0.3236 0.5
Echinococcus granulosus dro:myosuppressin receptor 0.0005 0.3236 0.5
Onchocerca volvulus 0.0005 0.3236 0.5
Onchocerca volvulus 0.0005 0.3236 0.5
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0005 0.3236 0.5
Brugia malayi G protein-coupled receptor F59B2.13 0.0005 0.3236 0.5
Loa Loa (eye worm) hypothetical protein 0.0005 0.3236 0.5
Echinococcus granulosus allatostatin A receptor 0.0005 0.3236 0.5
Onchocerca volvulus 0.0005 0.3236 0.5
Echinococcus multilocularis rhodopsin orphan GPCR 0.0005 0.3236 0.5
Echinococcus granulosus biogenic amine 5HT receptor 0.0005 0.3236 0.5
Loa Loa (eye worm) hypothetical protein 0.0005 0.3236 0.5
Loa Loa (eye worm) hypothetical protein 0.0005 0.3236 0.5
Schistosoma mansoni adenoreceptor 0.0005 0.3236 0.5
Echinococcus granulosus neuropeptide receptor 0.0005 0.3236 0.5
Echinococcus granulosus G protein coupled receptor 139 0.0005 0.3236 0.5
Loa Loa (eye worm) hypothetical protein 0.0005 0.3236 0.5
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0005 0.3236 0.5
Echinococcus granulosus rhodopsin orphan GPCR 0.0005 0.3236 0.5
Echinococcus multilocularis neuropeptide s receptor 0.0005 0.3236 0.5
Schistosoma mansoni neuropeptide receptor 0.0005 0.3236 0.5
Brugia malayi G-protein coupled receptor 0.0005 0.3236 0.5
Echinococcus multilocularis neuropeptide receptor 0.0005 0.3236 0.5
Loa Loa (eye worm) hypothetical protein 0.0005 0.3236 0.5
Brugia malayi hypothetical protein 0.0005 0.3236 0.5
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0005 0.3236 0.5
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0005 0.3236 0.5
Loa Loa (eye worm) hypothetical protein 0.0005 0.3236 0.5
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0005 0.3236 0.5
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0005 0.3236 0.5
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0005 0.3236 0.5
Schistosoma mansoni biogenic amine (5HT) receptor 0.0005 0.3236 0.5
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0005 0.3236 0.5
Loa Loa (eye worm) hypothetical protein 0.0005 0.3236 0.5
Schistosoma mansoni biogenic amine (5HT) receptor 0.0005 0.3236 0.5
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0005 0.3236 0.5
Loa Loa (eye worm) hypothetical protein 0.0005 0.3236 0.5
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0005 0.3236 0.5
Loa Loa (eye worm) hypothetical protein 0.0005 0.3236 0.5
Echinococcus granulosus orexin receptor type 2 0.0005 0.3236 0.5
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0005 0.3236 0.5
Echinococcus multilocularis dro:myosuppressin receptor 0.0005 0.3236 0.5
Loa Loa (eye worm) neuropeptide F receptor 0.0005 0.3236 0.5
Echinococcus multilocularis neuropeptides capa receptor 0.0005 0.3236 0.5
Echinococcus multilocularis neuropeptide Y receptor 0.0005 0.3236 0.5
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0005 0.3236 0.5
Brugia malayi AKH receptor 0.0005 0.3236 0.5
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0005 0.3236 0.5
Loa Loa (eye worm) hypothetical protein 0.0005 0.3236 0.5
Echinococcus multilocularis fmrfamide receptor 0.0005 0.3236 0.5
Loa Loa (eye worm) hypothetical protein 0.0005 0.3236 0.5
Echinococcus granulosus rhodopsin orphan GPCR 0.0005 0.3236 0.5
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0005 0.3236 0.5

Activities

Activity type Activity value Assay description Source Reference
Ratio (binding) = 0.28 /mM/min Ratio of Kinactivation to KI of guinea pig recombinant liver TGase expressed in Escherichia coli ChEMBL. 17092716

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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