Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | nitric oxide synthase 3 (endothelial cell) | Starlite/ChEMBL | References |
Homo sapiens | nitric oxide synthase 1 (neuronal) | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.015 | 0.0756 | 0.1195 |
Schistosoma mansoni | cercarial elastase (S01 family) | 0.015 | 0.0756 | 0.1195 |
Onchocerca volvulus | 0.015 | 0.0756 | 0.1195 | |
Toxoplasma gondii | calcium binding egf domain-containing protein | 0.0282 | 0.3445 | 0.3445 |
Schistosoma mansoni | cercarial elastase (S01 family) | 0.015 | 0.0756 | 0.1195 |
Leishmania major | hypothetical protein, conserved | 0.0424 | 0.6322 | 0.5 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0424 | 0.6322 | 0.5 |
Schistosoma mansoni | cercarial elastase (S01 family) | 0.015 | 0.0756 | 0.1195 |
Loa Loa (eye worm) | hypothetical protein | 0.0282 | 0.3445 | 0.545 |
Echinococcus multilocularis | fibrillin 1 | 0.0282 | 0.3445 | 0.545 |
Plasmodium vivax | cysteine repeat modular protein 1, putative | 0.0424 | 0.6322 | 0.5 |
Brugia malayi | Low-density lipoprotein receptor repeat class B containing protein | 0.0282 | 0.3445 | 0.545 |
Schistosoma mansoni | cercarial elastase (S01 family) | 0.015 | 0.0756 | 0.1195 |
Schistosoma mansoni | cercarial elastase (S01 family) | 0.015 | 0.0756 | 0.1195 |
Loa Loa (eye worm) | low-density lipoprotein receptor repeat class B containing protein | 0.0282 | 0.3445 | 0.545 |
Echinococcus multilocularis | laminin | 0.0282 | 0.3445 | 0.545 |
Toxoplasma gondii | kringle domain-containing protein | 0.0424 | 0.6322 | 0.6322 |
Brugia malayi | Trypsin family protein | 0.0414 | 0.6132 | 0.97 |
Onchocerca volvulus | 0.015 | 0.0756 | 0.1195 | |
Loa Loa (eye worm) | hypothetical protein | 0.015 | 0.0756 | 0.1195 |
Loa Loa (eye worm) | hypothetical protein | 0.015 | 0.0756 | 0.1195 |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.0414 | 0.6132 | 0.97 |
Echinococcus granulosus | Peptidase S1 S6 chymotrypsin Hap | 0.015 | 0.0756 | 0.1195 |
Onchocerca volvulus | 0.0424 | 0.6322 | 1 | |
Schistosoma mansoni | hypothetical protein | 0.015 | 0.0756 | 0.1195 |
Echinococcus multilocularis | subfamily S1A unassigned peptidase (S01 family) | 0.015 | 0.0756 | 0.1195 |
Loa Loa (eye worm) | hypothetical protein | 0.0282 | 0.3445 | 0.545 |
Echinococcus granulosus | Mastin | 0.015 | 0.0756 | 0.1195 |
Loa Loa (eye worm) | hypothetical protein | 0.0282 | 0.3445 | 0.545 |
Schistosoma mansoni | cercarial elastase (S01 family) | 0.015 | 0.0756 | 0.1195 |
Schistosoma mansoni | cercarial elastase (S01 family) | 0.015 | 0.0756 | 0.1195 |
Loa Loa (eye worm) | hypothetical protein | 0.015 | 0.0756 | 0.1195 |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.015 | 0.0756 | 0.1195 |
Loa Loa (eye worm) | hypothetical protein | 0.015 | 0.0756 | 0.1195 |
Echinococcus granulosus | Tolloid protein 1 | 0.0282 | 0.3445 | 0.545 |
Schistosoma mansoni | hypothetical protein | 0.0424 | 0.6322 | 1 |
Brugia malayi | Trypsin family protein | 0.015 | 0.0756 | 0.1195 |
Echinococcus multilocularis | transmembrane protease serine 3 | 0.015 | 0.0756 | 0.1195 |
Echinococcus multilocularis | Tolloid protein 1 | 0.0282 | 0.3445 | 0.545 |
Loa Loa (eye worm) | TK/ROR protein kinase | 0.0424 | 0.6322 | 1 |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.015 | 0.0756 | 0.1195 |
Onchocerca volvulus | 0.015 | 0.0756 | 0.1195 | |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.0414 | 0.6132 | 0.97 |
Onchocerca volvulus | 0.015 | 0.0756 | 0.1195 | |
Brugia malayi | Trypsin family protein | 0.015 | 0.0756 | 0.1195 |
Onchocerca volvulus | 0.0414 | 0.6132 | 0.97 | |
Brugia malayi | Kringle domain containing protein | 0.0424 | 0.6322 | 1 |
Schistosoma mansoni | subfamily M12A unassigned peptidase (M12 family) | 0.0282 | 0.3445 | 0.545 |
Echinococcus granulosus | tissue type plasminogen activator | 0.0424 | 0.6322 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0282 | 0.3445 | 0.545 |
Echinococcus multilocularis | Peptidase S1 S6, chymotrypsin Hap | 0.015 | 0.0756 | 0.1195 |
Schistosoma mansoni | cercarial elastase (S01 family) | 0.015 | 0.0756 | 0.1195 |
Schistosoma mansoni | septate junction protein | 0.0124 | 0.0224 | 0.0354 |
Schistosoma mansoni | hypothetical protein | 0.015 | 0.0756 | 0.1195 |
Echinococcus multilocularis | tissue type plasminogen activator | 0.0424 | 0.6322 | 1 |
Brugia malayi | Calcium binding EGF domain containing protein | 0.0282 | 0.3445 | 0.545 |
Brugia malayi | Trypsin family protein | 0.015 | 0.0756 | 0.1195 |
Onchocerca volvulus | 0.015 | 0.0756 | 0.1195 | |
Loa Loa (eye worm) | hypothetical protein | 0.0414 | 0.6132 | 0.97 |
Loa Loa (eye worm) | hypothetical protein | 0.0414 | 0.6132 | 0.97 |
Schistosoma mansoni | cercarial elastase (S01 family) | 0.015 | 0.0756 | 0.1195 |
Echinococcus granulosus | laminin | 0.0282 | 0.3445 | 0.545 |
Loa Loa (eye worm) | hypothetical protein | 0.015 | 0.0756 | 0.1195 |
Giardia lamblia | High cysteine protein | 0.0113 | 0 | 0.5 |
Toxoplasma gondii | calcium binding egf domain-containing protein | 0.0282 | 0.3445 | 0.3445 |
Schistosoma mansoni | aminopeptidase PILS (M01 family) | 0.015 | 0.0756 | 0.1195 |
Loa Loa (eye worm) | hypothetical protein | 0.0293 | 0.3669 | 0.5803 |
Brugia malayi | Chymotrypsin-like protease CTRL-1 precursor | 0.015 | 0.0756 | 0.1195 |
Brugia malayi | hypothetical protein | 0.015 | 0.0756 | 0.1195 |
Brugia malayi | Protein kinase domain containing protein | 0.0424 | 0.6322 | 1 |
Mycobacterium ulcerans | hypothetical protein | 0.015 | 0.0756 | 0.5 |
Echinococcus granulosus | glycoprotein Antigen 5 | 0.015 | 0.0756 | 0.1195 |
Echinococcus multilocularis | enteropeptidase | 0.015 | 0.0756 | 0.1195 |
Schistosoma mansoni | cercarial elastase (S01 family) | 0.015 | 0.0756 | 0.1195 |
Echinococcus granulosus | enteropeptidase | 0.015 | 0.0756 | 0.1195 |
Echinococcus granulosus | subfamily S1A unassigned peptidase S01 family | 0.015 | 0.0756 | 0.1195 |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.015 | 0.0756 | 0.1195 |
Echinococcus multilocularis | Mastin | 0.015 | 0.0756 | 0.1195 |
Loa Loa (eye worm) | hypothetical protein | 0.0424 | 0.6322 | 1 |
Toxoplasma gondii | PAN domain-containing protein | 0.0604 | 1 | 1 |
Loa Loa (eye worm) | bone morphogenetic protein 1b | 0.0282 | 0.3445 | 0.545 |
Loa Loa (eye worm) | trypsin family protein | 0.015 | 0.0756 | 0.1195 |
Onchocerca volvulus | Arrow homolog | 0.0282 | 0.3445 | 0.545 |
Schistosoma mansoni | cercarial elastase (S01 family) | 0.015 | 0.0756 | 0.1195 |
Echinococcus granulosus | transmembrane protease serine 3 | 0.015 | 0.0756 | 0.1195 |
Echinococcus multilocularis | glycoprotein Antigen 5 | 0.015 | 0.0756 | 0.1195 |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.015 | 0.0756 | 0.1195 |
Brugia malayi | Fibulin-1 precursor | 0.0282 | 0.3445 | 0.545 |
Schistosoma mansoni | egf-like domain protein | 0.0282 | 0.3445 | 0.545 |
Loa Loa (eye worm) | multiple epidermal growth factor-like domains 6 | 0.0282 | 0.3445 | 0.545 |
Plasmodium falciparum | cysteine repeat modular protein 1 | 0.0424 | 0.6322 | 0.5 |
Onchocerca volvulus | 0.0264 | 0.3083 | 0.4878 | |
Brugia malayi | Trypsin-like protease protein 5 | 0.015 | 0.0756 | 0.1195 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 0.8 uM | Inhibition of human neuronal NOS activity | ChEMBL. | 17317165 |
IC50 (binding) | = 0.8 uM | Inhibition of human neuronal NOS activity | ChEMBL. | 17317165 |
IC50 (binding) | = 13 uM | Inhibition of human endothelial NOS activity | ChEMBL. | 17317165 |
IC50 (binding) | = 13 uM | Inhibition of human endothelial NOS activity | ChEMBL. | 17317165 |
IC50 (binding) | = 91 uM | Inhibition of human inducible NOS activity | ChEMBL. | 17317165 |
IC50 (binding) | = 91 uM | Inhibition of human inducible NOS activity | ChEMBL. | 17317165 |
Ratio IC50 (binding) | = 16 | Selectivity for human nNOS over human eNOS | ChEMBL. | 17317165 |
Ratio IC50 (binding) | = 118 | Selectivity for human nNOS over human iNOS | ChEMBL. | 17317165 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.