Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Plasmodium falciparum | cysteine repeat modular protein 1 | 0.0818 | 1 | 0.5 |
Onchocerca volvulus | Arrow homolog | 0.0577 | 0.5415 | 0.5415 |
Toxoplasma gondii | PAN domain-containing protein | 0.0669 | 0.7157 | 0.3801 |
Loa Loa (eye worm) | hypothetical protein | 0.0577 | 0.5415 | 0.0812 |
Loa Loa (eye worm) | multiple epidermal growth factor-like domains 6 | 0.0577 | 0.5415 | 0.0812 |
Brugia malayi | Kringle domain containing protein | 0.0818 | 1 | 1 |
Toxoplasma gondii | kringle domain-containing protein | 0.0818 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0577 | 0.5415 | 0.0812 |
Plasmodium vivax | cysteine repeat modular protein 1, putative | 0.0818 | 1 | 0.5 |
Brugia malayi | Low-density lipoprotein receptor repeat class B containing protein | 0.0577 | 0.5415 | 0.0812 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0818 | 1 | 0.5 |
Loa Loa (eye worm) | TK/ROR protein kinase | 0.0818 | 1 | 1 |
Toxoplasma gondii | PAN domain-containing protein | 0.0669 | 0.7157 | 0.3801 |
Loa Loa (eye worm) | hypothetical protein | 0.0577 | 0.5415 | 0.0812 |
Onchocerca volvulus | 0.0556 | 0.5009 | 0.5009 | |
Loa Loa (eye worm) | low-density lipoprotein receptor repeat class B containing protein | 0.0577 | 0.5415 | 0.0812 |
Loa Loa (eye worm) | hypothetical protein | 0.0818 | 1 | 1 |
Echinococcus granulosus | tissue type plasminogen activator | 0.0818 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0577 | 0.5415 | 0.0812 |
Onchocerca volvulus | 0.0818 | 1 | 1 | |
Brugia malayi | Fibulin-1 precursor | 0.0577 | 0.5415 | 0.0812 |
Brugia malayi | Calcium binding EGF domain containing protein | 0.0577 | 0.5415 | 0.0812 |
Schistosoma mansoni | hypothetical protein | 0.0818 | 1 | 1 |
Schistosoma mansoni | subfamily M12A unassigned peptidase (M12 family) | 0.0577 | 0.5415 | 0.0812 |
Leishmania major | hypothetical protein, conserved | 0.0818 | 1 | 0.5 |
Schistosoma mansoni | egf-like domain protein | 0.0577 | 0.5415 | 0.0812 |
Loa Loa (eye worm) | bone morphogenetic protein 1b | 0.0577 | 0.5415 | 0.0812 |
Echinococcus multilocularis | tissue type plasminogen activator | 0.0818 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0589 | 0.5646 | 0.1275 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (functional) | Parasiticide activity against Saccharomyces cerevisiae | ChEMBL. | 17150358 | |
Activity (functional) | 0 | Parasiticidal activity against Ctenocephalides felis | ChEMBL. | 17150358 |
Activity (functional) | 0 | Parasiticide activity against Saccharomyces cerevisiae | ChEMBL. | 17150358 |
LD99 (functional) | = 1.7 uM | Parasiticidal activity against Bacillus subtilis | ChEMBL. | 17150358 |
LD99 (functional) | = 1.8 uM | Parasiticidal activity against Haemonchus contortus McMaster | ChEMBL. | 17150358 |
LD99 (functional) | = 2.2 uM | Parasiticidal activity against levamisole-resistant Haemonchus contortus Lawes | ChEMBL. | 17150358 |
LD99 (functional) | = 2.2 uM | Parasiticidal activity against benzimidazole-resistant Haemonchus contortus Lawes | ChEMBL. | 17150358 |
LD99 (functional) | = 2.2 uM | Parasiticidal activity against avermectin-resistant Haemonchus contortus CAVR | ChEMBL. | 17150358 |
LD99 (functional) | = 2.2 uM | Parasiticidal activity against Ostertagia circumcincta McMaster | ChEMBL. | 17150358 |
LD99 (functional) | = 9 uM | Parasiticidal activity against Trichostrongylus colubriformis | ChEMBL. | 17150358 |
LD99 (functional) | = 13 uM | Cytotoxicity against mouse NS1 cells | ChEMBL. | 17150358 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.