Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Plasmodium falciparum | V-type proton ATPase subunit C, putative | 0.0036 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0013 | 0.0802 | 0.0802 |
Entamoeba histolytica | vacuolar ATP synthase subunit C, putative | 0.0036 | 1 | 0.5 |
Plasmodium vivax | vacuolar ATP synthase subunit c, putative | 0.0036 | 1 | 0.5 |
Trypanosoma cruzi | vacuolar ATP synthase subunit c, putative | 0.0036 | 1 | 0.5 |
Schistosoma mansoni | subfamily S1B unassigned peptidase (S01 family) | 0.0013 | 0.0802 | 1 |
Echinococcus multilocularis | V type proton ATPase subunit C 1 A | 0.0013 | 0.0802 | 1 |
Trypanosoma brucei | vacuolar ATP synthase subunit c, putative | 0.0036 | 1 | 0.5 |
Brugia malayi | hypothetical protein | 0.0013 | 0.0802 | 0.0802 |
Trichomonas vaginalis | vacuolar ATP synthase subunit C, putative | 0.0036 | 1 | 0.5 |
Echinococcus granulosus | V type proton ATPase subunit C 1 A | 0.0013 | 0.0802 | 1 |
Onchocerca volvulus | 0.0013 | 0.0802 | 1 | |
Giardia lamblia | Vacuolar ATP synthase subunit C | 0.0036 | 1 | 0.5 |
Leishmania major | vacuolar ATP synthase subunit c, putative | 0.0036 | 1 | 0.5 |
Toxoplasma gondii | vacuolar ATP synthase subunit C, putative | 0.0036 | 1 | 0.5 |
Loa Loa (eye worm) | V-ATPase subunit C family protein | 0.0036 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | > 20 uM | Antiproliferative activity against p21 positive HCT116 cells by sulforhodamine B aasay | ChEMBL. | 17275298 |
IC50 (functional) | > 20 uM | Antiproliferative activity against p21 deficient 80S14 cells by sulforhodamine B aasay | ChEMBL. | 17275298 |
IC50 (functional) | > 20 uM | Antiproliferative activity against p21 positive HCT116 cells by sulforhodamine B aasay | ChEMBL. | 17275298 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.