Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma brucei | Aminopeptidase M1, putative | 0.0106 | 0 | 0.5 |
Trichomonas vaginalis | Clan MA, family M1, aminopeptidase N-like metallopeptidase | 0.0106 | 0 | 0.5 |
Echinococcus granulosus | aminopeptidase N | 0.0361 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0215 | 0.4293 | 0.5031 |
Loa Loa (eye worm) | hypothetical protein | 0.0254 | 0.5828 | 0.683 |
Loa Loa (eye worm) | hypothetical protein | 0.0323 | 0.8533 | 1 |
Loa Loa (eye worm) | cyclic AMP specific phosphodiesterase PDE4D5A | 0.0189 | 0.3263 | 0.3824 |
Echinococcus granulosus | cAMP specific 3'5' cyclic phosphodiesterase | 0.0189 | 0.3263 | 0.3263 |
Trichomonas vaginalis | Clan MA, family M1, aminopeptidase N-like metallopeptidase | 0.0106 | 0 | 0.5 |
Brugia malayi | Probable 3',5'-cyclic phosphodiesterase R153.1, putative | 0.0189 | 0.3263 | 0.3263 |
Echinococcus granulosus | cAMP specific 3'5' cyclic phosphodiesterase | 0.0215 | 0.4293 | 0.4293 |
Echinococcus multilocularis | cAMP specific 3',5' cyclic phosphodiesterase | 0.0215 | 0.4293 | 0.4293 |
Entamoeba histolytica | aminopeptidase, putative | 0.0106 | 0 | 0.5 |
Echinococcus granulosus | cAMP specific 3'5' cyclic phosphodiesterase | 0.0215 | 0.4293 | 0.4293 |
Trypanosoma cruzi | Aminopeptidase M1, putative | 0.0106 | 0 | 0.5 |
Leishmania major | aminopeptidase-like protein,metallo-peptidase, Clan MA(E), Family M1 | 0.0106 | 0 | 0.5 |
Schistosoma mansoni | camp-specific 35-cyclic phosphodiesterase | 0.0215 | 0.4293 | 1 |
Echinococcus multilocularis | cAMP specific 3',5' cyclic phosphodiesterase | 0.0215 | 0.4293 | 0.4293 |
Mycobacterium ulcerans | aminopeptidase N PepN | 0.0106 | 0 | 0.5 |
Loa Loa (eye worm) | peptidase family M1 containing protein | 0.0292 | 0.7295 | 0.8549 |
Echinococcus multilocularis | cAMP specific 3',5' cyclic phosphodiesterase | 0.0189 | 0.3263 | 0.3263 |
Giardia lamblia | CAMP-specific 3,5-cyclic phosphodiesterase 4B | 0.0215 | 0.4293 | 0.5 |
Trypanosoma cruzi | aminopeptidase, putative | 0.0106 | 0 | 0.5 |
Leishmania major | aminopeptidase, putative,metallo-peptidase, Clan MA(E), Family M1 | 0.0106 | 0 | 0.5 |
Echinococcus multilocularis | aminopeptidase N | 0.0361 | 1 | 1 |
Trypanosoma brucei | metallo-peptidase, Clan MA(E) Family M1 | 0.0106 | 0 | 0.5 |
Trypanosoma cruzi | metallo-peptidase, clan MA(E), family M1, putative | 0.0106 | 0 | 0.5 |
Trypanosoma brucei | Aminopeptidase M1, putative | 0.0106 | 0 | 0.5 |
Onchocerca volvulus | 0.0361 | 1 | 1 | |
Toxoplasma gondii | 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein | 0.0215 | 0.4293 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (binding) | = 15 % | Inhibition of metallo-beta-lactamases FEZ1 assessed as residual activity at 100 uM | ChEMBL. | 17157014 |
Activity (binding) | = 83 % | Inhibition of metallo-beta-lactamases IMP1 assessed as residual activity at 100 uM | ChEMBL. | 17157014 |
Activity (binding) | = 83 % | Inhibition of metallo-beta-lactamases IMP1 assessed as residual activity at 100 uM | ChEMBL. | 17157014 |
Activity (binding) | = 84 % | Inhibition of metallo-beta-lactamases CphA assessed as residual activity at 100 uM | ChEMBL. | 17157014 |
Activity (binding) | = 84 % | Inhibition of metallo-beta-lactamases CphA assessed as residual activity at 100 uM | ChEMBL. | 17157014 |
Activity (binding) | = 91 % | Inhibition of metallo-beta-lactamases Bc2 assessed as residual activity at 100 uM | ChEMBL. | 17157014 |
Activity (binding) | = 102 % | Inhibition of metallo-beta-lactamases L1 assessed as residual activity at 100 uM | ChEMBL. | 17157014 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.