Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | free fatty acid receptor 1 | Starlite/ChEMBL | References |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
%max (functional) | = 111 % | Agonist activity at GPR40 receptor expressed in CHO cells by reporter gene assay | ChEMBL. | 17240142 |
%max (functional) | = 111 % | Agonist activity at GPR40 receptor expressed in CHO cells by reporter gene assay | ChEMBL. | 17240142 |
EC50 (functional) | = -6 | Agonist activity at GPR40 receptor | ChEMBL. | 17240142 |
Log D | = 0.98 | Distribution coefficient, log D of the compound at pH 7.4 | ChEMBL. | 17240142 |
Log EC50 (functional) | = 6 | Agonist activity at GPR40 receptor | ChEMBL. | 17240142 |
Solubility | = 0.83 mg/ml | Solubility at pH 7.4 | ChEMBL. | 17240142 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.