Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | cholinergic receptor, muscarinic 3 | Starlite/ChEMBL | References |
Homo sapiens | cholinergic receptor, muscarinic 2 | Starlite/ChEMBL | References |
Homo sapiens | cholinergic receptor, muscarinic 1 | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | Get druggable targets OG5_133264 | All targets in OG5_133264 |
Loa Loa (eye worm) | hypothetical protein | Get druggable targets OG5_133264 | All targets in OG5_133264 |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | FTZ F1 nuclear receptor protein | 0.0523 | 1 | 0.5 |
Brugia malayi | nuclear hormone receptor | 0.0523 | 1 | 0.5 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0523 | 1 | 0.5 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-41 | 0.0523 | 1 | 1 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0523 | 1 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-31 | 0.0523 | 1 | 0.5 |
Echinococcus multilocularis | COUP TF:Svp nuclear hormone receptor | 0.0523 | 1 | 0.5 |
Echinococcus multilocularis | Nuclear hormone receptor family member nhr 41 | 0.0523 | 1 | 0.5 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-49 | 0.0523 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0523 | 1 | 1 |
Loa Loa (eye worm) | nuclear Hormone Receptor family member | 0.0523 | 1 | 1 |
Schistosoma mansoni | thyroid hormone receptor | 0.0523 | 1 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-3 | 0.0523 | 1 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-1 | 0.0523 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0523 | 1 | 1 |
Schistosoma mansoni | steroid hormone receptor ad4bp | 0.0523 | 1 | 0.5 |
Echinococcus granulosus | ecdysone induced protein 78C | 0.0523 | 1 | 0.5 |
Schistosoma mansoni | photoreceptor-specific nuclear receptor related | 0.0523 | 1 | 0.5 |
Schistosoma mansoni | thyroid hormone receptor | 0.0523 | 1 | 0.5 |
Echinococcus multilocularis | FTZ F1 alpha | 0.0523 | 1 | 0.5 |
Onchocerca volvulus | Protein ultraspiracle homolog | 0.0523 | 1 | 0.5 |
Onchocerca volvulus | Steroid hormone receptor family member cnr14 homolog | 0.0523 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0523 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0523 | 1 | 0.5 |
Echinococcus granulosus | Nuclear hormone receptor family member nhr 41 | 0.0523 | 1 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-41 | 0.0523 | 1 | 0.5 |
Schistosoma mansoni | FTZ-F1 nuclear receptor-like protein | 0.0523 | 1 | 0.5 |
Echinococcus granulosus | COUP TF:Svp nuclear hormone receptor | 0.0523 | 1 | 0.5 |
Onchocerca volvulus | Bile acid receptor homolog | 0.0523 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0523 | 1 | 1 |
Brugia malayi | Steroid receptor seven-up type 2 | 0.0523 | 1 | 0.5 |
Schistosoma mansoni | Tr4/Tr2 (homologue) | 0.0523 | 1 | 0.5 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0523 | 1 | 0.5 |
Echinococcus granulosus | hepatocyte nuclear factor 4 alpha | 0.0523 | 1 | 0.5 |
Onchocerca volvulus | 0.0523 | 1 | 0.5 | |
Schistosoma mansoni | nuclear hormone receptor nor-1/nor-2 | 0.0523 | 1 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-40 | 0.0523 | 1 | 0.5 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-40 | 0.0523 | 1 | 1 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0523 | 1 | 0.5 |
Echinococcus granulosus | retinoic acid receptor rxr beta a | 0.0523 | 1 | 0.5 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0523 | 1 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-14 | 0.0523 | 1 | 0.5 |
Echinococcus granulosus | FTZ F1 alpha | 0.0523 | 1 | 0.5 |
Brugia malayi | nuclear receptor NHR-88 | 0.0523 | 1 | 0.5 |
Echinococcus multilocularis | FTZ F1 nuclear receptor protein | 0.0523 | 1 | 0.5 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-31 | 0.0523 | 1 | 1 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0523 | 1 | 0.5 |
Schistosoma mansoni | nuclear receptor 2DBD-gamma | 0.0523 | 1 | 0.5 |
Brugia malayi | steroid hormone receptor | 0.0523 | 1 | 0.5 |
Loa Loa (eye worm) | steroid hormone receptor | 0.0523 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0523 | 1 | 1 |
Echinococcus multilocularis | thyroid hormone receptor alpha | 0.0523 | 1 | 0.5 |
Schistosoma mansoni | nuclear hormone receptor | 0.0523 | 1 | 0.5 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-14 | 0.0523 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0523 | 1 | 0.5 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-1 | 0.0523 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0523 | 1 | 0.5 |
Brugia malayi | photoreceptor-specific nuclear receptor | 0.0523 | 1 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-49 | 0.0523 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0523 | 1 | 1 |
Schistosoma mansoni | coup transcription factor | 0.0523 | 1 | 0.5 |
Echinococcus multilocularis | hepatocyte nuclear factor 4 alpha | 0.0523 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0523 | 1 | 1 |
Echinococcus multilocularis | ecdysone induced protein 78C | 0.0523 | 1 | 0.5 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.0523 | 1 | 0.5 |
Schistosoma mansoni | RAR-like nuclear receptor | 0.0523 | 1 | 0.5 |
Schistosoma mansoni | retinoic acid receptor RXR | 0.0523 | 1 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0523 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0523 | 1 | 1 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0523 | 1 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
ID50 (functional) | = 0.01 mg kg-1 | Inhibition of rhythmic bladder contraction in unanesthetized rat | ChEMBL. | 17188867 |
ID50 (functional) | = 0.2 mg kg-1 | Inhibition of methacholine induced salivation in anesthetized rat | ChEMBL. | 17188867 |
Ki (binding) | = 4.2 nM | Displacement of 1-[N-methyl- 3H]scopolamine from human muscarinic M3 receptor expressed in Sf9 cells | ChEMBL. | 17188867 |
Ki (binding) | = 4.2 nM | Displacement of 1-[N-methyl- 3H]scopolamine from human muscarinic M3 receptor expressed in Sf9 cells | ChEMBL. | 17188867 |
Ki (binding) | = 5.1 nM | Displacement of 1-[N-methyl- 3H]scopolamine from human muscarinic M2 receptor expressed in Sf9 cells | ChEMBL. | 17188867 |
Ki (binding) | = 5.1 nM | Displacement of 1-[N-methyl- 3H]scopolamine from human muscarinic M2 receptor expressed in Sf9 cells | ChEMBL. | 17188867 |
Ki (binding) | = 36 nM | Displacement of 1-[N-methyl- 3H]scopolamine from human muscarinic M1 receptor expressed in Sf9 cells | ChEMBL. | 17188867 |
Ki (binding) | = 36 nM | Displacement of 1-[N-methyl- 3H]scopolamine from human muscarinic M1 receptor expressed in Sf9 cells | ChEMBL. | 17188867 |
Ratio (functional) | = 20 | Ratio of ID50 for methacholine induced salivation to ID50 rhythmic bladder contraction in rat | ChEMBL. | 17188867 |
Ratio Ki (binding) | = 1.2 | Ratio of Ki for muscarinic M2 receptor to Ki for muscarinic M3 receptor | ChEMBL. | 17188867 |
Ratio Ki (binding) | = 8.6 | Ratio of Ki for muscarinic M1 receptor to Ki for muscarinic M3 receptor | ChEMBL. | 17188867 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.