Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | Trypsin family protein | 0.1361 | 0.0166 | 0.0177 |
Loa Loa (eye worm) | hypothetical protein | 0.1361 | 0.0166 | 0.0177 |
Loa Loa (eye worm) | hypothetical protein | 0.1361 | 0.0166 | 0.0177 |
Leishmania major | hypothetical protein, conserved | 0.5062 | 0.6646 | 0.5 |
Onchocerca volvulus | 0.1361 | 0.0166 | 0.0177 | |
Loa Loa (eye worm) | hypothetical protein | 0.1361 | 0.0166 | 0.0177 |
Loa Loa (eye worm) | TK/ROR protein kinase | 0.5062 | 0.6646 | 0.7072 |
Echinococcus granulosus | glycoprotein Antigen 5 | 0.1476 | 0.0368 | 0.0311 |
Brugia malayi | Protein kinase domain containing protein | 0.5062 | 0.6646 | 0.7072 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.5062 | 0.6646 | 0.5 |
Echinococcus granulosus | tissue type plasminogen activator | 0.5062 | 0.6646 | 1 |
Onchocerca volvulus | 0.1361 | 0.0166 | 0.0177 | |
Onchocerca volvulus | 0.5272 | 0.7015 | 0.7465 | |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.6633 | 0.9397 | 0.9387 |
Echinococcus multilocularis | enteropeptidase | 0.1476 | 0.0368 | 0.0311 |
Brugia malayi | hypothetical protein | 0.1361 | 0.0166 | 0.0177 |
Onchocerca volvulus | 0.1361 | 0.0166 | 0.0177 | |
Loa Loa (eye worm) | hypothetical protein | 0.1361 | 0.0166 | 0.0177 |
Echinococcus granulosus | enteropeptidase | 0.1476 | 0.0368 | 0.0311 |
Echinococcus multilocularis | tissue type plasminogen activator | 0.5062 | 0.6646 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.6633 | 0.9397 | 1 |
Plasmodium vivax | cysteine repeat modular protein 1, putative | 0.5062 | 0.6646 | 0.5 |
Brugia malayi | Trypsin-like protease protein 5 | 0.1361 | 0.0166 | 0.0177 |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.1525 | 0.0455 | 0.0293 |
Loa Loa (eye worm) | trypsin family protein | 0.1361 | 0.0166 | 0.0177 |
Echinococcus granulosus | Mastin | 0.1476 | 0.0368 | 0.0311 |
Onchocerca volvulus | 0.5062 | 0.6646 | 0.7072 | |
Mycobacterium ulcerans | hypothetical protein | 0.1361 | 0.0166 | 0.5 |
Echinococcus multilocularis | glycoprotein Antigen 5 | 0.1476 | 0.0368 | 0.0311 |
Loa Loa (eye worm) | hypothetical protein | 0.1361 | 0.0166 | 0.0177 |
Plasmodium falciparum | cysteine repeat modular protein 1 | 0.5062 | 0.6646 | 0.5 |
Toxoplasma gondii | kringle domain-containing protein | 0.5062 | 0.6646 | 1 |
Brugia malayi | Trypsin family protein | 0.1361 | 0.0166 | 0.0177 |
Brugia malayi | Trypsin family protein | 0.1361 | 0.0166 | 0.0177 |
Schistosoma mansoni | hypothetical protein | 0.5062 | 0.6646 | 0.6589 |
Onchocerca volvulus | 0.6633 | 0.9397 | 1 | |
Loa Loa (eye worm) | hypothetical protein | 0.5062 | 0.6646 | 0.7072 |
Brugia malayi | Kringle domain containing protein | 0.5062 | 0.6646 | 0.7072 |
Onchocerca volvulus | 0.1361 | 0.0166 | 0.0177 | |
Echinococcus multilocularis | Mastin | 0.1476 | 0.0368 | 0.0311 |
Loa Loa (eye worm) | hypothetical protein | 0.6633 | 0.9397 | 1 |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.1476 | 0.0368 | 0.0205 |
Onchocerca volvulus | 0.1361 | 0.0166 | 0.0177 | |
Brugia malayi | Chymotrypsin-like protease CTRL-1 precursor | 0.1361 | 0.0166 | 0.0177 |
Brugia malayi | Trypsin family protein | 0.6633 | 0.9397 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Diuretic activity (functional) | = 250 | Salidiuretic activity in dog following i.v. dosing at 5 mg/kg | ChEMBL. | 7452697 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.