Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma brucei | inosine-adenosine-guanosine-nucleosidehydrolase | 0.044 | 0.5 | 0.5 |
Trypanosoma cruzi | inosine-adenosine-guanosine-nucleosidehydrolase, putative | 0.044 | 0.5 | 0.5 |
Trypanosoma cruzi | inosine-adenosine-guanosine-nucleosidehydrolase, putative | 0.044 | 0.5 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (binding) | = 0 % | Displacement of [3H]8-OH-DPAT from 5HT1A receptor at 10 uM | ChEMBL. | 17407813 |
Activity (binding) | = 0 % | Displacement of [3H]8-OH-DPAT from 5HT1A receptor at 10 uM | ChEMBL. | 17407813 |
Activity (binding) | = 53 % | Displacement of [3H]Mesulergine from 5HT2C receptor at 10 uM | ChEMBL. | 17407813 |
Activity (binding) | = 53 % | Displacement of [3H]Mesulergine from 5HT2C receptor at 10 uM | ChEMBL. | 17407813 |
Activity (binding) | = 86 % | Displacement of [3H]YM091512 from dopamine D3 receptor at 10 uM | ChEMBL. | 17407813 |
Activity (binding) | = 86 % | Displacement of [3H]YM091512 from dopamine D3 receptor at 10 uM | ChEMBL. | 17407813 |
Activity (binding) | = 90 % | Displacement of [3H]YM091512 from dopamine D2 receptor at 10 uM | ChEMBL. | 17407813 |
Activity (binding) | = 90 % | Displacement of [3H]YM091512 from dopamine D2 receptor at 10 uM | ChEMBL. | 17407813 |
Activity (binding) | = 94 % | Displacement of [3H]Ketanserin from 5HT2A receptor at 10 uM | ChEMBL. | 17407813 |
Activity (binding) | = 94 % | Displacement of [3H]Ketanserin from 5HT2A receptor at 10 uM | ChEMBL. | 17407813 |
Activity (binding) | = 97 % | Displacement of [3H]SCH23390 from dopamine D1 receptor at 10 uM | ChEMBL. | 17407813 |
Activity (binding) | = 97 % | Displacement of [3H]SCH23390 from dopamine D1 receptor at 10 uM | ChEMBL. | 17407813 |
MIC (functional) | > 10 ug ml-1 | Antitubercular activity against Mycobacterium tuberculosis H37Rv by MABA assay | ChEMBL. | 17407813 |
MIC (functional) | > 10 ug ml-1 | Antitubercular activity against Mycobacterium tuberculosis H37Rv by MABA assay | ChEMBL. | 17407813 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.