Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Chlamydia trachomatis | glutamine binding protein | 0.0038 | 0 | 0.5 |
Mycobacterium tuberculosis | Probable D-amino acid oxidase Aao | 0.0143 | 0.8895 | 1 |
Echinococcus multilocularis | nmda type glutamate receptor | 0.0053 | 0.127 | 0.5 |
Mycobacterium ulcerans | D-amino acid oxidase Aao | 0.0156 | 1 | 1 |
Mycobacterium leprae | PROBABLE D-AMINO ACID OXIDASE AAO | 0.0156 | 1 | 0.5 |
Treponema pallidum | amino acid ABC transporter, periplasmic binding protein | 0.0038 | 0 | 0.5 |
Treponema pallidum | amino acid ABC transporter, periplasmic binding protein (hisJ) | 0.0038 | 0 | 0.5 |
Echinococcus multilocularis | Glutamate receptor, ionotropic kainate 3 | 0.0053 | 0.127 | 0.5 |
Schistosoma mansoni | d-amino acid oxidase | 0.0156 | 1 | 0.5 |
Chlamydia trachomatis | arginine ABC transporter substrate-binding protein ArtJ | 0.0038 | 0 | 0.5 |
Echinococcus granulosus | nmda type glutamate receptor | 0.0053 | 0.127 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
MIC (functional) | = 0.1 ug ml-1 | Antibacterial activity against Staphylococcus aureus 209P JC1 by agar dilution method | ChEMBL. | 17502146 |
MIC (functional) | = 0.5 ug ml-1 | Antibacterial activity against Pseudomonas aeruginosa N101 by agar dilution method | ChEMBL. | 17502146 |
MIC (functional) | = 1.56 ug ml-1 | Antibacterial activity against Escherichia coli NIH JC2 by agar dilution method | ChEMBL. | 17502146 |
MIC (functional) | = 1.56 ug ml-1 | Antibacterial activity against Escherichia coli NIH JC2 by agar dilution method | ChEMBL. | 17502146 |
MIC (functional) | = 2 ug ml-1 | Antibacterial activity against Pseudomonas aeruginosa PAO1 by agar dilution method | ChEMBL. | 17502146 |
MIC (functional) | = 3.13 ug ml-1 | Antibacterial activity against methicillin-resistant Staphylococcus aureus MF490 by agar dilution method | ChEMBL. | 17502146 |
MIC (functional) | = 6.25 ug ml-1 | Antibacterial activity against methicillin-resistant Staphylococcus aureus MSC03571 by agar dilution method | ChEMBL. | 17502146 |
MIC (functional) | = 50 ug ml-1 | Antibacterial activity against Pseudomonas aeruginosa GN315 by agar dilution method | ChEMBL. | 17502146 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.